QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (21) Citing Articles via Google Scholar Google Scholar Articles by Jenkins, T. A. Articles by Aggleton, J. P. Search for Related Content PubMed PubMed Citation Articles by Jenkins, T. A. Articles by Aggleton, J. P.

 Previous Article  |  Next Article 

The Journal of Neuroscience, June 15, 2002, 22(12):5230-5238

Fos Imaging Reveals that Lesions of the Anterior Thalamic Nuclei Produce Widespread Limbic Hypoactivity in Rats

Trisha A. Jenkins¹, Rebecca Dias¹, Eman Amin¹, Malcolm W. Brown², and John P. Aggleton¹

¹ School of Psychology, Cardiff University, Cardiff CF10 3YG, United Kingdom, and ² Department of Anatomy, University of Bristol Medical School, Bristol BS8 1TD, United Kingdom

Activity of the immediate early gene c-fos was compared in rats with neurotoxic lesions of the anterior thalamic nuclei and in surgical controls. Fos levels were measured after rats had been placed in a novel room and allowed to run up and down preselected arms of a radial maze. An additional control group showed that in normal rats, this exposure to a novel room leads to a Fos increase in a number of structures, including the anterior thalamic nuclei and hippocampus. In contrast, rats with anterior thalamic lesions were found to have significantly less Fos-positive cells in an array of sites, including the hippocampus (dorsal and ventral), retrosplenial cortex, anterior cingulate cortex, and prelimbic cortex. These results show that anterior thalamic lesions disrupt multiple limbic brain regions, producing hypoactivity in sites associated in rats with spatial memory. Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia.

Key words: amnesia; hippocampus; immediate early genes; limbic cortices; rat; spatial memory; thalamus

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22125230-09$05.00/0

This article has been cited by other articles:

				D. L. F. Garden, P. V. Massey, D. A. Caruana, B. Johnson, E. C. Warburton, J. P. Aggleton, and Z. I. Bashir Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia Brain, July 1, 2009; 132(7): 1847 - 1857. [Abstract] [Full Text] [PDF]

				J. H. Hollis, M. J. McKinley, M. D'Souza, J. Kampe, and B. J. Oldfield The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1390 - R1401. [Abstract] [Full Text] [PDF]

				S. Kubik, T. Miyashita, and J. F. Guzowski Using immediate-early genes to map hippocampal subregional functions Learn. Mem., November 15, 2007; 14(11): 758 - 770. [Abstract] [Full Text] [PDF]

				A. S. Mitchell and J. C. Dalrymple-Alford Lateral and anterior thalamic lesions impair independent memory systems. Learn. Mem., May 1, 2006; 13(3): 388 - 396. [Abstract] [Full Text] [PDF]

				M. Wolff, S. J. Gibb, and J. C. Dalrymple-Alford Beyond spatial memory: the anterior thalamus and memory for the temporal order of a sequence of odor cues. J. Neurosci., March 15, 2006; 26(11): 2907 - 2913. [Abstract] [Full Text] [PDF]

				M. Caulo, J. Van Hecke, L. Toma, A. Ferretti, A. Tartaro, C. Colosimo, G. L. Romani, and A. Uncini Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome Brain, July 1, 2005; 128(7): 1584 - 1594. [Abstract] [Full Text] [PDF]

				L. M. Savage, Q. Chang, and P. E. Gold Diencephalic Damage Decreases Hippocampal Acetylcholine Release During Spontaneous Alternation Testing Learn. Mem., July 1, 2003; 10(4): 242 - 246. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help