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The Journal of Neuroscience, July 15, 2002, 22(14):5797-5802

BRIEF COMMUNICATION
Role for Reelin in the Development of Granule Cell Dispersion in Temporal Lobe Epilepsy

Carola A. Haas¹, Oliver Dudeck², Matthias Kirsch¹, Csaba Huszka¹, Gunda Kann¹, Stefan Pollak³, Josef Zentner², and Michael Frotscher¹

¹ Institute of Anatomy, ² Department of Neurosurgery, and ³ Institute of Forensic Medicine, University of Freiburg, D-79001 Freiburg, Germany

The reelin signaling pathway plays a crucial role during the development of laminated structures in the mammalian brain. Reelin, which is synthesized and secreted by Cajal-Retzius cells in the marginal zone of the neocortex and hippocampus, is proposed to act as a stop signal for migrating neurons. Here we show that a decreased expression of reelin mRNA by hippocampal Cajal-Retzius cells correlates with the extent of migration defects in the dentate gyrus of patients with temporal lobe epilepsy. These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy.

Key words: human hippocampus; extracellular matrix; neuronal migration disorder; Cajal-Retzius cells; dentate gyrus; Ammon's horn sclerosis

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22145797-06$05.00/0

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