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The Journal of Neuroscience, August 1, 2002, 22(15):6773-6780

Altered Nucleus Accumbens Circuitry Mediates Pain-Induced Antinociception in Morphine-Tolerant Rats

Brian L. Schmidt^{1, 2, 3}, Claudia H. Tambeli^{2, 3, 7}, Justine Barletta^{2, 3}, Lei Luo^{2, 3}, Paul Green^{2, 3}, Jon D. Levine^{2, 3, 4, 5, 6}, and Robert W. Gear^{2, 3}

¹ Graduate Program in Oral Biology, ² Department of Oral and Maxillofacial Surgery, ³ National Institutes of Health Pain Center (University of California at San Francisco), Departments of ⁴ Anatomy and ⁵ Medicine, and ⁶ Division of Neuroscience, University of California, San Francisco, California 94143, and ⁷ Faculty of Dentistry of Piracicaba, University of Campinas, Campinas, Brazil, 13414900

We investigated the effect of chronic administration of morphine on noxious stimulus-induced antinociception (NSIA) produced by intraplantar capsaicin injection. In the untreated (naïve) rat, we previously found that NSIA depends on activation of dopamine, nicotinic acetylcholine, and µ- and -opioid receptors in nucleus accumbens. Rats chronically implanted with subcutaneous morphine pellets demonstrated tolerance to the antinociceptive effects of acute systemic morphine administration but did not show cross-tolerance to NSIA. Morphine pretreatment, however, significantly reduced NSIA dependence on intra-accumbens opioid receptors but not on dopamine or nicotinic acetylcholine receptors. As observed in naïve rats, intra-accumbens microinjection of either the dopamine receptor antagonist flupentixol or the nicotinic receptor antagonist mecamylamine blocked NSIA in rats tolerant to the antinociceptive effects of morphine, but, in contrast to naïve rats, intra-accumbens microinjection of either the µ-receptor antagonist Cys²,Tyr³,Orn⁵,Pen⁷ amide or the -receptor antagonist naltrindole failed to block NSIA. These findings suggest that although NSIA is dependent on nucleus accumbens opioid receptors in the naïve state, this dependence disappears in rats tolerant to the antinociceptive effects of morphine, which may account for the lack of NSIA cross-tolerance. In separate experiments, intra-accumbens extracellular dopamine levels were measured using microdialysis. Dopamine levels increased after either capsaicin or systemic morphine administration in naïve rats but only after capsaicin administration in morphine pretreated rats. Thus, intra-accumbens dopamine release paralleled antinociceptive responses in naïve and morphine pretreated rats.

Key words: nucleus accumbens; morphine; tolerance; antinociception; dopamine release; noxious stimulation; capsaicin; pain; analgesia; µ opioid receptors; opioid receptors; microdialysis; jaw-opening reflex

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22156773-08$05.00/0

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