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The Journal of Neuroscience, August 15, 2002, 22(16):6856-6862
Neuronal T-type
1H Calcium Channels Induce Neuritogenesis and Expression of High-Voltage-Activated Calcium Channels in the NG108-15 Cell Line
Jean Chemin, Joël Nargeot, and Philippe Lory Institut de Génétique Humaine, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1142, F-34396 Montpellier cedex 05, France
Neuronal differentiation involves both morphological and electrophysiological changes, which depend on calcium influx. Voltage-gated calcium channels (VGCCs) represent a major route for calcium entry into neurons. The recently cloned low-voltage-activated T-type calcium channels (T-channels) are the first class of VGCCs functionally expressed in most developing neurons, as well as in neuroblastoma cell lines, but their roles in neuronal development are yet unknown. Here, we document the part played by T-channels in neuronal differentiation. Using NG108-15, a cell line that recapitulates early steps of neuronal differentiation, we demonstrate that blocking T-currents by nickel, mibefradil, or the endogenous cannabinoid anandamide prevents neuritogenesis without affecting neurite outgrowth. Similar results were obtained using antisense oligodeoxynucleotides directed against the
1H T-channel subunit. Furthermore, we describe that inhibition of
Key words: T-type calcium channel; differentiation; neuritogenesis; HVA calcium channel; neuroblastoma NG108-15 cell line; antisense
Copyright © 2002 Society for Neuroscience 0270-6474/02/22166856-07$05.00/0
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