 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, August 15, 2002, 22(16):6885-6890
Modulation of Presynaptic Calcium Transients by Metabotropic Glutamate Receptor Activation: A Differential Role in Acute Depression of Synaptic Transmission and Long-Term Depression
Guido C. Faas, Hita Adwanikar, Robert W. Gereau IV, and Peter Saggau Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
Activation of group I metabotropic glutamate receptors (mGluRs) can induce acute depression of excitatory synaptic transmission and long-term depression (LTD) in area CA1 of the rat hippocampus. The underlying mechanisms for both forms of depression are unknown. By measuring presynaptic calcium transients, we show that a reduction in the stimulation-induced presynaptic calcium rise that triggers vesicular release causes the acute depression of transmission by group I mGluRs. In contrast, the mechanism underlying mGluR-induced LTD does not involve a persistent change in stimulation-induced calcium influx. However, analysis of paired-pulse facilitation experiments suggests a presynaptic location for expression of this form of LTD. Furthermore, we show that mGluR-induced LTD can be completely blocked by a specific mGluR5 antagonist, whereas mGluR1 antagonists strongly attenuate the acute depression of transmission. These results support the hypothesis that the acute depression of transmission caused by activation of group I mGluRs involves regulation of stimulation-induced presynaptic calcium transients, whereas mGluR-induced LTD involves a distinct presynaptic modulation downstream of calcium influx.
Key words: mGluR; DHPG; LTD; presynaptic; calcium; hippocampus
Copyright © 2002 Society for Neuroscience 0270-6474/02/22166885-06$05.00/0
This article has been cited by other articles:
D. R. Ireland and W. C. Abraham
Mechanisms of Group I mGluR-Dependent Long-Term Depression of NMDA Receptor-Mediated Transmission at Schaffer Collateral-CA1 Synapses
J Neurophysiol, March 1, 2009; 101(3): 1375 - 1385.
[Abstract] [Full Text] [PDF]
P. R. Moult, S. A. L. Correa, G. L. Collingridge, S. M. Fitzjohn, and Z. I. Bashir
Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression
J. Physiol., May 15, 2008; 586(10): 2499 - 2510.
[Abstract] [Full Text] [PDF]
H. E. Speed and L. E. Dobrunz
Developmental Decrease in Short-Term Facilitation at Schaffer Collateral Synapses in Hippocampus Is mGluR1 Sensitive
J Neurophysiol, February 1, 2008; 99(2): 799 - 813.
[Abstract] [Full Text] [PDF]
A. Kumar and T. C. Foster
Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses
J Neurophysiol, November 1, 2007; 98(5): 2729 - 2736.
[Abstract] [Full Text] [PDF]
T. Kirschstein, M. Bauer, L. Muller, C. Ruschenschmidt, M. Reitze, A. J. Becker, S. Schoch, and H. Beck
Loss of Metabotropic Glutamate Receptor-Dependent Long-Term Depression via Downregulation of mGluR5 after Status Epilepticus
J. Neurosci., July 18, 2007; 27(29): 7696 - 7704.
[Abstract] [Full Text] [PDF]
F. Chaouloff, A. Hemar, and O. Manzoni
Acute Stress Facilitates Hippocampal CA1 Metabotropic Glutamate Receptor-Dependent Long-Term Depression
J. Neurosci., July 4, 2007; 27(27): 7130 - 7135.
[Abstract] [Full Text] [PDF]
D. A. Rusakov
Ca2+-Dependent Mechanisms of Presynaptic Control at Central Synapses
Neuroscientist, August 1, 2006; 12(4): 317 - 326.
[Abstract] [PDF]
W. Zhang and D. J. Linden
Long-term depression at the mossy fiber-deep cerebellar nucleus synapse.
J. Neurosci., June 28, 2006; 26(26): 6935 - 6944.
[Abstract] [Full Text] [PDF]
J. Qian and J. L. Noebels
Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse.
J. Neurosci., May 31, 2006; 26(22): 6089 - 6095.
[Abstract] [Full Text] [PDF]
L. J. Volk, C. A. Daly, and K. M. Huber
Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression
J Neurophysiol, April 1, 2006; 95(4): 2427 - 2438.
[Abstract] [Full Text] [PDF]
B. A. Grueter, H. B. Gosnell, C. M. Olsen, N. L. Schramm-Sapyta, T. Nekrasova, G. E. Landreth, and D. G. Winder
Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration.
J. Neurosci., March 22, 2006; 26(12): 3210 - 3219.
[Abstract] [Full Text] [PDF]
H. Mutoh, Q. Yuan, and T. Knopfel
Long-Term Depression at Olfactory Nerve Synapses
J. Neurosci., April 27, 2005; 25(17): 4252 - 4259.
[Abstract] [Full Text] [PDF]
Y. Rao and N. W. Daw
Layer Variations of Long-Term Depression in Rat Visual Cortex
J Neurophysiol, November 1, 2004; 92(5): 2652 - 2658.
[Abstract] [Full Text] [PDF]
L. Hou and E. Klann
Activation of the Phosphoinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Pathway Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression
J. Neurosci., July 14, 2004; 24(28): 6352 - 6361.
[Abstract] [Full Text] [PDF]
C. Kushmerick, G. D. Price, H. Taschenberger, N. Puente, R. Renden, J. I. Wadiche, R. M. Duvoisin, P. Grandes, and H. von Gersdorff
Retroinhibition of Presynaptic Ca2+ Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse
J. Neurosci., June 30, 2004; 24(26): 5955 - 5965.
[Abstract] [Full Text] [PDF]
C.-C. Huang, J.-L. You, M.-Y. Wu, and K.-S. Hsu
Rap1-induced p38 Mitogen-activated Protein Kinase Activation Facilitates AMPA Receptor Trafficking via the GDI{middle dot}Rab5 Complex: POTENTIAL ROLE IN (S)-3,5-DIHYDROXYPHENYLGLYCINE-INDUCED LONG TERM DEPRESSION
J. Biol. Chem., March 26, 2004; 279(13): 12286 - 12292.
[Abstract] [Full Text] [PDF]
H. Zhang and D. Sulzer
Glutamate Spillover in the Striatum Depresses Dopaminergic Transmission by Activating Group I Metabotropic Glutamate Receptors
J. Neurosci., November 19, 2003; 23(33): 10585 - 10592.
[Abstract] [Full Text] [PDF]
S. Kourrich and C. A. Chapman
NMDA Receptor-Dependent Long-Term Synaptic Depression in the Entorhinal Cortex In Vitro
J Neurophysiol, April 1, 2003; 89(4): 2112 - 2119.
[Abstract] [Full Text] [PDF]
G. Rammes, M. Palmer, M. Eder, H.-U. Dodt, W. Zieglgansberger, and G. L Collingridge
Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices
J. Physiol., January 15, 2003; 546(2): 455 - 460.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|