 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, October 1, 2002, 22(19):8541-8552
Refinement of Thalamocortical Arbors and Emergence of Barrel Domains in the Primary Somatosensory Cortex: A Study of Normal and Monoamine Oxidase A Knock-Out Mice
Alexandra Rebsam1, Isabelle Seif2, and Patricia Gaspar1 1 Institut National de la Santé et de la Recherche Médicale U106, Hopital Pitié-Salpêtrière, 75013 Paris, France, and 2 Faculté de pharmacie, Université Paris Sud, 92296 Châtenay Malabry, France
In the rodent primary somatosensory cortex, the thalamocortical axons (TCAs) are organized into clusters that correspond to functional units in the periphery. Around these axons, neurons in layer IV aggregate as barrels. To understand how this organization emerges, we analyzed TCA development in mice that do not form barrels, the monoamine oxidase A knock-out (MAOA-KO), and in MAOA/5-HT1B receptor double-KO mice, which have a restored barrel field. We show that TCAs already attain cortical layer IV on the day of birth. They are uniformly distributed in this layer from postnatal day 0 (P0) to P2 and secondarily coalesce into barrel domains in layer IV, over a 3 d period (P3-P5), with no prepatterning in the deeper layers. In MAOA-KO mice, the uniform distribution of the TC projection is maintained, and no axon clusters emerge. Individual TCA arbors were traced after carbocyanine injections. At P1, TCAs were poorly branched and covered variable tangential widths, encompassing one to two prospective barrels. At P7 the number of TCA branches increased 10-fold in layer IV and became restricted to one barrel. In MAOA-KO mice, there was a 50% reduction of the TCA terminal branches in layer IV, with a 40% increase in their tangential extent. These defects were corrected in the MAOA/5-HT1B double knock-out mice, indicating an effect of the presynaptic 5-HT1B receptor on axon branching. Our results indicate that the barrel-deficient phenotype of MAOA-KO mice results from an altered refinement of the TCA arbors in their target layer IV, involving branch elaboration and collateral retraction during early postnatal life.
Key words: serotonin; activity-dependent mechanisms; synaptic stabilization; axon growth; axon branch formation; collateral retraction
Copyright © 2002 Society for Neuroscience 0270-6474/02/22198541-12$05.00/0
This article has been cited by other articles:
V. Gil, Z. Bichler, J. K. Lee, O. Seira, F. Llorens, A. Bribian, R. Morales, E. Claverol-Tinture, E. Soriano, L. Sumoy, et al.
Developmental Expression of the Oligodendrocyte Myelin Glycoprotein in the Mouse Telencephalon
Cereb Cortex, November 5, 2009; (2009) bhp246v1.
[Abstract] [Full Text] [PDF]
C. Giaume, M. Maravall, E. Welker, and G. Bonvento
The Barrel Cortex as a Model to Study Dynamic Neuroglial Interaction
Neuroscientist, August 1, 2009; 15(4): 351 - 366.
[Abstract] [PDF]
M. C. Piñon, A. Jethwa, E. Jacobs, A. Campagnoni, and Z.án Molnár
Dynamic integration of subplate neurons into the cortical barrel field circuitry during postnatal development in the Golli-tau-eGFP (GTE) mouse
J. Physiol., May 1, 2009; 587(9): 1903 - 1915.
[Abstract] [Full Text] [PDF]
L. S. Wijetunge, S. M. Till, T. H. Gillingwater, C. A. Ingham, and P. C. Kind
mGluR5 Regulates Glutamate-Dependent Development of the Mouse Somatosensory Cortex
J. Neurosci., December 3, 2008; 28(49): 13028 - 13037.
[Abstract] [Full Text] [PDF]
Y. Hayano and N. Yamamoto
Activity-Dependent Thalamocortical Axon Branching
Neuroscientist, August 1, 2008; 14(4): 359 - 368.
[Abstract] [PDF]
T. Iwasato, M. Inan, H. Kanki, R. S. Erzurumlu, S. Itohara, and M. C. Crair
Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development
J. Neurosci., June 4, 2008; 28(23): 5931 - 5943.
[Abstract] [Full Text] [PDF]
V. Houades, A. Koulakoff, P. Ezan, I. Seif, and C. Giaume
Gap Junction-Mediated Astrocytic Networks in the Mouse Barrel Cortex
J. Neurosci., May 14, 2008; 28(20): 5207 - 5217.
[Abstract] [Full Text] [PDF]
C. Takasaki, R. Okada, A. Mitani, M. Fukaya, M. Yamasaki, Y. Fujihara, T. Shirakawa, K. Tanaka, and M. Watanabe
Glutamate Transporters Regulate Lesion-Induced Plasticity in the Developing Somatosensory Cortex
J. Neurosci., May 7, 2008; 28(19): 4995 - 5006.
[Abstract] [Full Text] [PDF]
M. S. Ansorge, E. Morelli, and J. A. Gingrich
Inhibition of Serotonin But Not Norepinephrine Transport during Development Produces Delayed, Persistent Perturbations of Emotional Behaviors in Mice
J. Neurosci., January 2, 2008; 28(1): 199 - 207.
[Abstract] [Full Text] [PDF]
C Altamura, M. Dell'Acqua, R Moessner, D. Murphy, K. Lesch, and A. M. Persico
Altered Neocortical Cell Density and Layer Thickness in Serotonin Transporter Knockout Mice: A Quantitation Study
Cereb Cortex, June 1, 2007; 17(6): 1394 - 1401.
[Abstract] [Full Text] [PDF]
F. Gheorghita, R. Kraftsik, R. Dubois, and E. Welker
Structural Basis for Map Formation in the Thalamocortical Pathway of the Barrelless Mouse
J. Neurosci., September 27, 2006; 26(39): 10057 - 10067.
[Abstract] [Full Text] [PDF]
H.-C. Lu, D. A. Butts, P. S. Kaeser, W.-C. She, R. Janz, and M. C. Crair
Role of efficient neurotransmitter release in barrel map development.
J. Neurosci., March 8, 2006; 26(10): 2692 - 2703.
[Abstract] [Full Text] [PDF]
M. W. Barnett, R. F. Watson, T. Vitalis, K. Porter, N. H. Komiyama, P. N. Stoney, T. H. Gillingwater, S. G. N. Grant, and P. C. Kind
Synaptic Ras GTPase Activating Protein Regulates Pattern Formation in the Trigeminal System of Mice
J. Neurosci., February 1, 2006; 26(5): 1355 - 1365.
[Abstract] [Full Text] [PDF]
B. Kocsis, V. Varga, L. Dahan, and A. Sik
Serotonergic neuron diversity: Identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm
PNAS, January 24, 2006; 103(4): 1059 - 1064.
[Abstract] [Full Text] [PDF]
T. Esaki, M. Cook, K. Shimoji, D. L. Murphy, L. Sokoloff, and A. Holmes
Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice
PNAS, April 12, 2005; 102(15): 5582 - 5587.
[Abstract] [Full Text] [PDF]
L.-J. Lee, F.-S. Lo, and R. S. Erzurumlu
NMDA Receptor-Dependent Regulation of Axonal and Dendritic Branching
J. Neurosci., March 2, 2005; 25(9): 2304 - 2311.
[Abstract] [Full Text] [PDF]
S. Higashi, K. Hioki, T. Kurotani, N. Kasim, and Z. Molnar
Functional Thalamocortical Synapse Reorganization from Subplate to Layer IV during Postnatal Development in the Reeler-Like Mutant Rat (Shaking Rat Kawasaki)
J. Neurosci., February 9, 2005; 25(6): 1395 - 1406.
[Abstract] [Full Text] [PDF]
A. Rebsam, I. Seif, and P. Gaspar
Dissociating Barrel Development and Lesion-Induced Plasticity in the Mouse Somatosensory Cortex
J. Neurosci., January 19, 2005; 25(3): 706 - 710.
[Abstract] [Full Text] [PDF]
K. J. Bender, J. Rangel, and D. E. Feldman
Development of Columnar Topography in the Excitatory Layer 4 to Layer 2/3 Projection in Rat Barrel Cortex
J. Neurosci., September 24, 2003; 23(25): 8759 - 8770.
[Abstract] [Full Text] [PDF]
Y.-Q. Ding, J. Yin, H.-M. Xu, M. F. Jacquin, and Z.-F. Chen
Formation of Whisker-Related Principal Sensory Nucleus-Based Lemniscal Pathway Requires a Paired Homeodomain Transcription Factor, Drg11
J. Neurosci., August 13, 2003; 23(19): 7246 - 7254.
[Abstract] [Full Text] [PDF]
A. Ravary, A. Muzerelle, D. Herve, V. Pascoli, K. N. Ba-Charvet, J.-A. Girault, E. Welker, and P. Gaspar
Adenylate Cyclase 1 as a Key Actor in the Refinement of Retinal Projection Maps
J. Neurosci., March 15, 2003; 23(6): 2228 - 2238.
[Abstract] [Full Text] [PDF]
K. Poskanzer, L. A. Needleman, O. Bozdagi, and G. W. Huntley
N-Cadherin Regulates Ingrowth and Laminar Targeting of Thalamocortical Axons
J. Neurosci., March 15, 2003; 23(6): 2294 - 2305.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|