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The Journal of Neuroscience, October 1, 2002, 22(19):8563-8573

Frizzled-3 Is Required for the Development of Major Fiber Tracts in the Rostral CNS

Yanshu Wang^{1, 4}, Nupur Thekdi¹, Philip M. Smallwood^{1, 4}, Jennifer P. Macke^{1, 4}, and Jeremy Nathans^{1, 2, 3, 4}

¹ Departments of Molecular Biology and Genetics, ² Neuroscience, and ³ Ophthalmology, ⁴ Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Many ligand/receptor families are known to contribute to axonal growth and targeting. Thus far, there have been no reports implicating Wnts and Frizzleds in this process, despite their large numbers and widespread expression within the CNS. In this study, we show that targeted deletion of the mouse fz3 gene leads to severe defects in several major axon tracts within the forebrain. In particular, fz3(/) mice show a complete loss of the thalamocortical, corticothalamic, and nigrostriatal tracts and of the anterior commissure, and they show a variable loss of the corpus callosum. Peripheral nerve fibers and major axon tracts in the more caudal regions of the CNS are mostly or completely unaffected. Cell proliferation in the ventricular zone and cell migration to the developing cortex proceed normally until at least embryonic day 14. Extensive cell death in the fz3(/) striatum occurs late in gestation, perhaps secondary to the nearly complete absence of long-range connections. In contrast, there is little cell death, as assayed by terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling, in the cortex. These data provide the first link between Frizzled signaling and axonal development.

Key words: axonal growth; fiber tracts; frizzled; mouse brain development; forebrain; Wnt signaling

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Copyright © 2002 Society for Neuroscience  0270-6474/02/22198563-11$05.00/0

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