 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, October 1, 2002, 22(19):8748-8753
Amygdalo-Hypothalamic Circuit Allows Learned Cues to Override Satiety and Promote Eating
Gorica D. Petrovich, Barry Setlow, Peter C. Holland, and Michela Gallagher Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218
Organisms eat not only in a response to signals related to energy balance. Eating also occurs in response to "extrinsic," or environmental, signals, including learned cues. Such cues can modify feeding based on motivational value acquired through association with either rewarding or aversive events. We provide evidence that a specific brain system, involving connections between basolateral amygdala and the lateral hypothalamus, is crucial for allowing learned cues (signals that were paired with food delivery when the animal was hungry) to override satiety and promote eating in sated rats. In an assessment of second-order conditioning, we also found that disconnection of this circuitry had no effect on the ability of a conditioned cue to support new learning. Knowledge about neural systems through which food-associated cues specifically control feeding behavior provides a defined model for the study of learning that may be informative for understanding mechanisms that contribute to eating disorders and more moderate forms of overeating.
Key words: amygdala; hypothalamus; eating; feeding behavior; learning; goal-directed behavior; motivation
Copyright © 2002 Society for Neuroscience 0270-6474/02/22198748-06$05.00/0
This article has been cited by other articles:
G. D. Petrovich, C. A. Ross, P. C. Holland, and M. Gallagher
Medial Prefrontal Cortex Is Necessary for an Appetitive Contextual Conditioned Stimulus to Promote Eating in Sated Rats
J. Neurosci., June 13, 2007; 27(24): 6436 - 6441.
[Abstract] [Full Text] [PDF]
B. M. King
Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1201 - R1214.
[Abstract] [Full Text] [PDF]
J. Le Merrer and D. N. Stephens
Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake.
J. Neurosci., July 5, 2006; 26(27): 7163 - 7171.
[Abstract] [Full Text] [PDF]
J. D. Beaver, A. D. Lawrence, J. van Ditzhuijzen, M. H. Davis, A. Woods, and A. J. Calder
Individual differences in reward drive predict neural responses to images of food.
J. Neurosci., May 10, 2006; 26(19): 5160 - 5166.
[Abstract] [Full Text] [PDF]
G. D. Petrovich, P. C. Holland, and M. Gallagher
Amygdalar and Prefrontal Pathways to the Lateral Hypothalamus Are Activated by a Learned Cue That Stimulates Eating
J. Neurosci., September 7, 2005; 25(36): 8295 - 8302.
[Abstract] [Full Text] [PDF]
N. Darcel, G. Fromentin, H. E. Raybould, S. Gougis, D. W. Gietzen, and D. Tome
Fos-Positive Neurons Are Increased in the Nucleus of the Solitary Tract and Decreased in the Ventromedial Hypothalamus and Amygdala by a High-Protein Diet in Rats
J. Nutr., June 1, 2005; 135(6): 1486 - 1490.
[Abstract] [Full Text] [PDF]
M. A. McDannald, M. P. Saddoris, M. Gallagher, and P. C. Holland
Lesions of Orbitofrontal Cortex Impair Rats' Differential Outcome Expectancy Learning But Not Conditioned Stimulus-Potentiated Feeding
J. Neurosci., May 4, 2005; 25(18): 4626 - 4632.
[Abstract] [Full Text] [PDF]
S. C. Benoit, D. J. Clegg, J. G. Barrera, R. J. Seeley, and S. C. Woods
Learned Meal Initiation Attenuates the Anorexic Effects of the Melanocortin Agonist MTII
Diabetes, November 1, 2003; 52(11): 2684 - 2688.
[Abstract] [Full Text] [PDF]
G. Schoenbaum and B. Setlow
Lesions of Nucleus Accumbens Disrupt Learning about Aversive Outcomes
J. Neurosci., October 29, 2003; 23(30): 9833 - 9841.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|