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The Journal of Neuroscience, January 15, 2002, 22(2):428-436

Mutation of Drosophila homer Disrupts Control of Locomotor Activity and Behavioral Plasticity

Thierry T. Diagana¹, Ulrich Thomas², Sergei N. Prokopenko¹, Bo Xiao³, Paul F. Worley³, and John B. Thomas¹

¹ Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, San Diego, California 92186, ² Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany, and ³ Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Homer proteins have been proposed to play a role in synaptogenesis, synapse function, receptor trafficking, and axon pathfinding. Here we report the isolation and characterization of the Drosophila gene homer, the single Homer-related gene in fly. Using anti-Homer antibody we show that Homer is expressed in a broad range of tissues but is highly enriched in the CNS. Similarly to its mammalian counterpart, the Drosophila Homer localizes to the dendrites and the endoplasmic reticulum (ER). This subcellular distribution is dependent on an intact Enabled/Vasp homology 1 domain, suggesting that Homer must bind to one or more of its partners for proper localization. We have created a mutation of homer and show that flies homozygous for this mutation are viable and show coordinated locomotion, suggesting that Homer is not essential for basic neurotransmission. However, we found that homer mutants display defects in behavioral plasticity and the control of locomotor activity. Our results argue that in the CNS, Homer-related proteins operate in the ER and in dendrites to regulate the development and function of neural networks underlying locomotor control and behavioral plasticity.

Key words: Drosophila; Homer; dendrites; locomotion; courtship; behavioral plasticity

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Copyright © 2002 Society for Neuroscience  0270-6474/02/222428-09$05.00/0

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