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Previous Article | Next Article
The Journal of Neuroscience, January 15, 2002, 22(2):437-445
Multipotent Neural Stem Cells Reside into the Rostral Extension and Olfactory Bulb of Adult Rodents
Angela Gritti1, Luca Bonfanti2, Fiona Doetsch3, Isabelle Caille3, Arturo Alvarez-Buylla3, Daniel A. Lim3, Rossella Galli1, Jose Manuel Garcia Verdugo4, Daniel G. Herrera1, and Angelo L. Vescovi1 1 Institute for Stem Cell Research, Department of Biotechnology, San Raffaele Hospital, 20132 Milan, Italy, 2 Department of Morphophysiology, University of Turin, 10100 Turin, Italy, 3 The Rockefeller University, New York, New York 10021, and 4 University of Valencia, Burjasot, 46100 Spain
The lateral walls of the forebrain lateral ventricles are the richest source of stem cells in the adult mammalian brain. These stem cells give rise to new olfactory neurons that are renewed throughout life. The neurons originate in the subventricular zone (SVZ), migrate within the rostral extension (RE) of the SVZ along the rostral migratory stream (RMS) within tube-like structures formed of glial cells, to eventually reach the olfactory bulb (OB). We demonstrate that, contrary to the current view, multipotential (neuronal-astroglial-oligodendroglial) precursors with stem cell features can be isolated not only from the SVZ but also from the entire RE, including the distal portion within the OB. Specifically, these stem cells do not derive from the migratory neuroblasts coming from the SVZ. Interestingly, stem cells isolated from the proximal RE generate significantly more oligodendrocytes, and those from the distal RE proliferate significantly more slowly than stem cells derived from the SVZ and other RE regions. These findings demonstrate that stem cells are not confined to the forebrain periventricular region and indicate that stem cells endowed with different functional characteristics occur at different levels of the SVZ-RE pathway.
Key words: adult neural stem cells; multipotent precursors; forebrain subventricular region; rostral extension; olfactory bulb; neurogenesis
Copyright © 2002 Society for Neuroscience 0270-6474/02/222437-09$05.00/0
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