QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Yang, H. Articles by Goldowitz, D. Search for Related Content PubMed PubMed Citation Articles by Yang, H. Articles by Goldowitz, D.

 Previous Article  |  Next Article 

The Journal of Neuroscience, January 15, 2002, 22(2):464-470

The Community Effect and Purkinje Cell Migration in the Cerebellar Cortex: Analysis of Scrambler Chimeric Mice

Huaitao Yang, Patricia Jensen, and Dan Goldowitz

Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163

The Disabled-1 protein in mouse is known to be an intercellular signaling component of the Reelin molecular pathway that subserves neuronal migration in several structures in the brain and spinal cord. The scrambler mutant mouse, which is phenotypically identical to the reeler mouse, is due to a mutation in the disabled-1 gene (Howell et al., 1997; Sheldon et al., 1997). The Purkinje cells of the cerebellum express Disabled-1 and experience a massive failure of migration in the scrambler mutant mouse (Howell et al., 1997; Sheldon et al., 1997; Gallagher et al., 1998; Rice et al., 1998). We sought to define the developmental basis of this mutation by studying the Purkinje cell population in experimental mouse aggregation chimeras using a cell marker that permitted the identification of neurons derived from the mutant lineage. We found that a genetically normal component to the environment cannot assist scrambler mutant Purkinje cells in the migratory process. However, the presence of a mutant component to the environment can cause the ectopia of wild-type Purkinje cells. There appears to be a linear relationship between the percentage of the cerebellum that is genetically mutant and the number of wild-type Purkinje cells that express a mutant phenotype. These studies point to the interplay between cell-intrinsic and cell-extrinsic properties in the migration of neurons to form laminated structures during CNS development.

Key words: cerebellum; neuronal migration; mouse chimeras; Disabled-1; Reelin; Purkinje cell

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/222464-07$05.00/0

This article has been cited by other articles:

				T. Uchida, A. Baba, F. J. Perez-Martinez, T. Hibi, T. Miyata, J. M. Luque, K. Nakajima, and M. Hattori Downregulation of Functional Reelin Receptors in Projection Neurons Implies That Primary Reelin Action Occurs atEarly/Premigratory Stages J. Neurosci., August 26, 2009; 29(34): 10653 - 10662. [Abstract] [Full Text] [PDF]

				S. M. Curristin, A. Cao, W. B. Stewart, H. Zhang, J. A. Madri, J. S. Morrow, and L. R. Ment Disrupted synaptic development in the hypoxic newborn brain PNAS, November 26, 2002; 99(24): 15729 - 15734. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help