 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 2002, 22(2):592-599
Effects of Transient Focal Inactivation of the Basal Ganglia in Parkinsonian Primates
Mark S. Baron, Thomas Wichmann, Demin Ma, and Mahlon R. DeLong Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322
Ablative and chronic stimulation procedures targeting the internal pallidum (GPi) and the subthalamic nucleus (STN) have led to major advancements in the treatment of Parkinson's disease and other movement disorders. Although these procedures have evolved to primarily target the posterior ventrolateral sensorimotor portion of GPi and to less selectively target STN, centrally, the ideal targets within these structures remain to be fully established. In this study, we sought to identify the optimal targeting sites in GPi and STN for reversal of parkinsonian signs through a series of reversible injections of the GABAA agonist muscimol in these nuclei in parkinsonian primates.
Akinesia and bradykinesia were strongly ameliorated by discrete inactivation within the centromedial extent of the sensorimotor territory in GPi and the lateral portion of the sensorimotor territory in STN. This suggests that akinesia and bradykinesia might, in fact, originate from abnormalities in the same, or at least overlapping, motor circuits in the parkinsonian state. Inactivation of areas outside of the motor territories did not improve parkinsonism but induced circling and behavioral abnormalities. The segregation of basal ganglia-thalamocortical circuits appears to be therefore maintained, at least to a large extent, in the parkinsonian state.
These results underscore that inactivation of discrete regions in the central territory of GPi and the lateral portion of STN are sufficient to ameliorate parkinsonian motor signs and that extension of lesions into nonmotor territories may be deleterious. Surgical outcomes might therefore be optimized by placing more discrete lesions and by restricting the extent of chronic stimulation.
Key words: basal ganglia; globus pallidus; subthalamic nucleus; Parkinson's disease; pallidotomy; deep brain stimulation
Copyright © 2002 Society for Neuroscience 0270-6474/02/222592-08$05.00/0
This article has been cited by other articles:
K. W. McCairn and R. S. Turner
Deep Brain Stimulation of the Globus Pallidus Internus in the Parkinsonian Primate: Local Entrainment and Suppression of Low-Frequency Oscillations
J Neurophysiol, April 1, 2009; 101(4): 1941 - 1960.
[Abstract] [Full Text] [PDF]
M. Desmurget and R. S. Turner
Testing Basal Ganglia Motor Functions Through Reversible Inactivations in the Posterior Internal Globus Pallidus
J Neurophysiol, March 1, 2008; 99(3): 1057 - 1076.
[Abstract] [Full Text] [PDF]
E. F. Chang, R. S. Turner, J. L. Ostrem, V. R. Davis, and P. A. Starr
Neuronal Responses to Passive Movement in the Globus Pallidus Internus in Primary Dystonia
J Neurophysiol, December 1, 2007; 98(6): 3696 - 3707.
[Abstract] [Full Text] [PDF]
P. Belujon, E. Bezard, A. Taupignon, B. Bioulac, and A. Benazzouz
Noradrenergic Modulation of Subthalamic Nucleus Activity: Behavioral and Electrophysiological Evidence in Intact and 6-Hydroxydopamine-Lesioned Rats
J. Neurosci., September 5, 2007; 27(36): 9595 - 9606.
[Abstract] [Full Text] [PDF]
J. E. Castner, H. J. Chenery, D. A. Copland, T. J. Coyne, F. Sinclair, and P. A. Silburn
Semantic and affective priming as a function of stimulation of the subthalamic nucleus in Parkinson's disease
Brain, May 1, 2007; 130(5): 1395 - 1407.
[Abstract] [Full Text] [PDF]
A. Gillies and D. Willshaw
Membrane Channel Interactions Underlying Rat Subthalamic Projection Neuron Rhythmic and Bursting Activity
J Neurophysiol, April 1, 2006; 95(4): 2352 - 2365.
[Abstract] [Full Text] [PDF]
A. A. Kuhn, M. I. Hariz, P. Silberstein, S. Tisch, A. Kupsch, G. -H. Schneider, P. Limousin-Dowsey, K. Yarrow, and P. Brown
Activation of the subthalamic region during emotional processing in Parkinson disease
Neurology, September 13, 2005; 65(5): 707 - 713.
[Abstract] [Full Text] [PDF]
A. Galvan, R. M. Villalba, S. M. West, N. T. Maidment, L. C. Ackerson, Y. Smith, and T. Wichmann
GABAergic Modulation of the Activity of Globus Pallidus Neurons in Primates: In Vivo Analysis of the Functions of GABA Receptors and GABA Transporters
J Neurophysiol, August 1, 2005; 94(2): 990 - 1000.
[Abstract] [Full Text] [PDF]
V Czernecki, B Pillon, J L Houeto, M L Welter, V Mesnage, Y Agid, and B Dubois
Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease?
J. Neurol. Neurosurg. Psychiatry, June 1, 2005; 76(6): 775 - 779.
[Abstract] [Full Text] [PDF]
J. Soares, M. A. Kliem, R. Betarbet, J. T. Greenamyre, B. Yamamoto, and T. Wichmann
Role of External Pallidal Segment in Primate Parkinsonism: Comparison of the Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonism and Lesions of the External Pallidal Segment
J. Neurosci., July 21, 2004; 24(29): 6417 - 6426.
[Abstract] [Full Text] [PDF]
T. Wichmann and M. A. Kliem
Neuronal Activity in the Primate Substantia Nigra Pars Reticulata During the Performance of Simple and Memory-Guided Elbow Movements
J Neurophysiol, February 1, 2004; 91(2): 815 - 827.
[Abstract] [Full Text] [PDF]
D. Nandi, T. Z. Aziz, N. Giladi, J. Winter, and J. F. Stein
Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus
Brain, November 1, 2002; 125(11): 2418 - 2430.
[Abstract] [Full Text] [PDF]
C. Perier, L. Tremblay, J. Feger, and E. C. Hirsch
Behavioral Consequences of Bicuculline Injection in the Subthalamic Nucleus and the Zona Incerta in Rat
J. Neurosci., October 1, 2002; 22(19): 8711 - 8719.
[Abstract] [Full Text] [PDF]
N. Breysse, C. Baunez, W. Spooren, F. Gasparini, and M. Amalric
Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism
J. Neurosci., July 1, 2002; 22(13): 5669 - 5678.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|