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The Journal of Neuroscience, 2002, 22:RC197:1-5

RAPID COMMUNICATION
Hippocampal Pyramidal Cell-Interneuron Spike Transmission Is Frequency Dependent and Responsible for Place Modulation of Interneuron Discharge

Lisa Marshall, Darrell A. Henze, Hajime Hirase, Xavier Leinekugel, George Dragoi, and György Buzsáki

Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102

The interplay between principal cells and interneurons plays an important role in timing the activity of individual cells. We investigated the influence of single hippocampal CA1 pyramidal cells on putative interneurons. The activity of CA1 pyramidal cells was controlled intracellularly by current injection, and the activity of neighboring interneurons was recorded extracellularly in the urethane-anesthetized rat. Spike transmission probability between monosynaptically connected pyramidal cell-interneuron pairs was frequency dependent and highest between 5 and 25 Hz. In the awake animal, interneurons were found that had place-modulated firing rates, with place maps similar to their presynaptic pyramidal neuron. Thus, single pyramidal neurons can effectively determine the firing patterns of their interneuron targets.

Key words: hippocampus; spike transmission; interneuron; depression; place cells; temporal coding

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Copyright © Society for Neuroscience  0270-6474//$05.00/0

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