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The Journal of Neuroscience, October 15, 2002, 22(20):8785-8789
BRIEF COMMUNICATION
Identification of the Nicotinic Receptor Subtypes Expressed on
Dopaminergic Terminals in the Rat Striatum
Michele
Zoli1,
Milena
Moretti2,
Alessio
Zanardi1,
J. Michael
McIntosh3,
Francesco
Clementi2, and
Cecilia
Gotti2
1 Department of Biomedical Sciences, Section of
Physiology, University of Modena and Reggio Emilia, 41100 Modena,
Italy, 2 Consiglio Nazionale delle Ricerche, Institute of
Neuroscience, Cellular and Molecular Pharmacology, Department of
Medical Pharmacology and Center of Excellence on Neurodegenerative
Diseases, University of Milan, 20129 Milan, Italy, and
3 Department of Biology, University of Utah, Salt Lake
City, Utah 84112
Neuronal nicotinic acetylcholine receptors (nAChRs) expressed on
mesostriatal dopaminergic neurons are thought to mediate several
behavioral effects of nicotine, including locomotion, habit learning,
and reinforcement. Using immunoprecipitation and ligand-binding
techniques, we have shown that both  6 2* and 4(non6)2* nAChRs are expressed in the caudate-putamen and that only 6* nAChRs
can bind -conotoxin MII and methyllycaconitine with affinities of
1.3 and 40 nM, respectively. Further studies performed on
6-hydroxydopamine-lesioned striatum led to the identification of nAChR
subtypes selectively expressed on dopaminergic terminals
[452, 462(3), and 62(3)], nondopaminergic neuronal structures (242), or both structures (42). The identification of the nAChRs expressed on striatal dopaminergic terminals opens up the possibility of developing selective
nAChR ligands active on dopaminergic systems and associated diseases,
such as Parkinson's disease.
Key words:
nicotinic acetylcholine receptor; mesostriatal dopamine
pathway; striatum; immunoprecipitation; 6-hydroxydopamine; -conotoxin MII
Copyright © 2002 Society for Neuroscience 0270-6474/02/22208785-05$05.00/0
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165(9):
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|
|
|
|
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|
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[Full Text]
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|
|
|
|
|
|
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646 - 654.
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|
|
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|
|
|
|
|
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|
|
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|
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|
|
|
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|
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|
|
|
|
|
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|
|
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|
|
|
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|
|
|
|
|
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|
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|
|
|
|
|
|
|
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70(4):
1350 - 1357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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70(4):
1358 - 1368.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Xu, Y. Zhu, and S. F. Heinemann
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26(38):
9780 - 9793.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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70(3):
967 - 976.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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318(1):
381 - 388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. R. Abdrakhmanova, M. I. Damaj, F. I. Carroll, and B. R. Martin
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[Full Text]
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|
|
|
|
|
|
|
M. Quik and J. M. McIntosh
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316(2):
481 - 489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Marritt, B. C. Cox, R. P. Yasuda, J. M. McIntosh, Y. Xiao, B. B. Wolfe, and K. J. Kellar
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68(6):
1656 - 1668.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Parish, J. Nunan, D. I. Finkelstein, F. N. McNamara, J. Y. Wong, J. L. Waddington, R. M. Brown, A. J. Lawrence, M. K. Horne, and J. Drago
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Mol. Pharmacol.,
November 1, 2005;
68(5):
1376 - 1386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Turner and K. J. Kellar
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J. Neurosci.,
October 5, 2005;
25(40):
9258 - 9265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gotti, M. Moretti, A. Zanardi, A. Gaimarri, N. Champtiaux, J.-P. Changeux, P. Whiteaker, M. J. Marks, F. Clementi, and M. Zoli
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Mol. Pharmacol.,
October 1, 2005;
68(4):
1162 - 1171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. McCallum, N. Parameswaran, T. Bordia, J. M. McIntosh, S. R. Grady, and M. Quik
Decrease in {alpha}3*/{alpha}6* Nicotinic Receptors but Not Nicotine-Evoked Dopamine Release in Monkey Brain after Nigrostriatal Damage
Mol. Pharmacol.,
September 1, 2005;
68(3):
737 - 746.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gotti, M. Moretti, F. Clementi, L. Riganti, J. M. McIntosh, A. C. Collins, M. J. Marks, and P. Whiteaker
Expression of Nigrostriatal {alpha}6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by {beta}3 Subunit Gene Deletion
Mol. Pharmacol.,
June 1, 2005;
67(6):
2007 - 2015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lai, N. Parameswaran, M. Khwaja, P. Whiteaker, J. M. Lindstrom, H. Fan, J. M. McIntosh, S. R. Grady, and M. Quik
Long-Term Nicotine Treatment Decreases Striatal {alpha}6* Nicotinic Acetylcholine Receptor Sites and Function in Mice
Mol. Pharmacol.,
May 1, 2005;
67(5):
1639 - 1647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. P. Grinevich, S. R. Letchworth, K. A. Lindenberger, J. Menager, V. Mary, K. A. Sadieva, L. M. Buhlman, G. A. Bohme, L. Pradier, J. Benavides, et al.
Heterologous Expression of Human {alpha}6{beta}4{beta}3{alpha}5 Nicotinic Acetylcholine Receptors: Binding Properties Consistent with Their Natural Expression Require Quaternary Subunit Assembly Including the {alpha}5 Subunit
J. Pharmacol. Exp. Ther.,
February 1, 2005;
312(2):
619 - 626.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Azam and J. M. McIntosh
Effect of Novel {alpha}-Conotoxins on Nicotine-Stimulated [3H]Dopamine Release from Rat Striatal Synaptosomes
J. Pharmacol. Exp. Ther.,
January 1, 2005;
312(1):
231 - 237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Quik, S. Vailati, T. Bordia, J. M. Kulak, H. Fan, J. M. McIntosh, F. Clementi, and C. Gotti
Subunit Composition of Nicotinic Receptors in Monkey Striatum: Effect of Treatments with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA
Mol. Pharmacol.,
January 1, 2005;
67(1):
32 - 41.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Sacco, K. L. Bannon, and T. P. George
Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders
J Psychopharmacol,
December 1, 2004;
18(4):
457 - 474.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Moretti, S. Vailati, M. Zoli, G. Lippi, L. Riganti, R. Longhi, A. Viegi, F. Clementi, and C. Gotti
Nicotinic Acetylcholine Receptor Subtypes Expression during Rat Retina Development and Their Regulation by Visual Experience
Mol. Pharmacol.,
July 1, 2004;
66(1):
85 - 96.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Luetje
Getting Past the Asterisk: the Subunit Composition of Presynaptic Nicotinic Receptors That Modulate Striatal Dopamine Release
Mol. Pharmacol.,
June 1, 2004;
65(6):
1333 - 1335.
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Salminen, K. L. Murphy, J. M. McIntosh, J. Drago, M. J. Marks, A. C. Collins, and S. R. Grady
Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice
Mol. Pharmacol.,
June 1, 2004;
65(6):
1526 - 1535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Wehrwein, S. A. Thompson, S. F. Coulibaly, D. M. Linn, and C. L. Linn
Acetylcholine Protection of Adult Pig Retinal Ganglion Cells from Glutamate-Induced Excitotoxicity
Invest. Ophthalmol. Vis. Sci.,
May 1, 2004;
45(5):
1531 - 1543.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Santos, J. M. McIntosh, D. R. Hillyard, L. J. Cruz, and B. M. Olivera
The A-superfamily of Conotoxins: STRUCTURAL AND FUNCTIONAL DIVERGENCE
J. Biol. Chem.,
April 23, 2004;
279(17):
17596 - 17606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. McIntosh, L. Azam, S. Staheli, C. Dowell, J. M. Lindstrom, A. Kuryatov, J. E. Garrett, M. J. Marks, and P. Whiteaker
Analogs of {alpha}-Conotoxin MII Are Selective for {alpha}6-Containing Nicotinic Acetylcholine Receptors
Mol. Pharmacol.,
April 1, 2004;
65(4):
944 - 952.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. L. Parker, Y. Fu, K. McAllen, J. Luo, J. M. McIntosh, J. M. Lindstrom, and B. M. Sharp
Up-Regulation of Brain Nicotinic Acetylcholine Receptors in the Rat during Long-Term Self-Administration of Nicotine: Disproportionate Increase of the {alpha}6 Subunit
Mol. Pharmacol.,
March 1, 2004;
65(3):
611 - 622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. TERLAU and B. M. OLIVERA
Conus Venoms: A Rich Source of Novel Ion Channel-Targeted Peptides
Physiol Rev,
January 1, 2004;
84(1):
41 - 68.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Middleton, W. A. Cass, and L. P. Dwoskin
Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex
J. Pharmacol. Exp. Ther.,
January 1, 2004;
308(1):
367 - 377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cui, T. K. Booker, R. S. Allen, S. R. Grady, P. Whiteaker, M. J. Marks, O. Salminen, T. Tritto, C. M. Butt, W. R. Allen, et al.
The {beta}3 Nicotinic Receptor Subunit: A Component of {alpha}-Conotoxin MII-Binding Nicotinic Acetylcholine Receptors that Modulate Dopamine Release and Related Behaviors
J. Neurosci.,
December 3, 2003;
23(35):
11045 - 11053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Volpicelli-Daley, A. Hrabovska, E. G. Duysen, S. M. Ferguson, R. D. Blakely, O. Lockridge, and A. I. Levey
Altered Striatal Function and Muscarinic Cholinergic Receptors in Acetylcholinesterase Knockout Mice
Mol. Pharmacol.,
December 1, 2003;
64(6):
1309 - 1316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Dowell, B. M. Olivera, J. E. Garrett, S. T. Staheli, M. Watkins, A. Kuryatov, D. Yoshikami, J. M. Lindstrom, and J. M. McIntosh
{alpha}-Conotoxin PIA Is Selective for {alpha}6 Subunit-Containing Nicotinic Acetylcholine Receptors
J. Neurosci.,
September 17, 2003;
23(24):
8445 - 8452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Quik, T. Bordia, M. Okihara, H. Fan, M. J. Marks, J. M. McIntosh, and P. Whiteaker
L-DOPA Treatment Modulates Nicotinic Receptors in Monkey Striatum
Mol. Pharmacol.,
September 1, 2003;
64(3):
619 - 628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. P. Grinevich, P. A. Crooks, S. P. Sumithran, A. J. Haubner, J. T. Ayers, and L. P. Dwoskin
N-n-Alkylpyridinium Analogs, a Novel Class of Nicotinic Receptor Antagonists: Selective Inhibition of Nicotine-Evoked [3H]Dopamine Overflow from Superfused Rat Striatal Slices
J. Pharmacol. Exp. Ther.,
September 1, 2003;
306(3):
1011 - 1020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Champtiaux, C. Gotti, M. Cordero-Erausquin, D. J. David, C. Przybylski, C. Lena, F. Clementi, M. Moretti, F. M. Rossi, N. Le Novere, et al.
Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice
J. Neurosci.,
August 27, 2003;
23(21):
7820 - 7829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Kitabatake, T. Hikida, D. Watanabe, I. Pastan, and S. Nakanishi
Impairment of reward-related learning by cholinergic cell ablation in the striatum
PNAS,
June 24, 2003;
100(13):
7965 - 7970.
[Abstract]
[Full Text]
[PDF]
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M. Quik, J. D. Sum, P. Whiteaker, S. E. McCallum, M. J. Marks, J. Musachio, J. M. Mcintosh, A. C. Collins, and S. R. Grady
Differential Declines in Striatal Nicotinic Receptor Subtype Function after Nigrostriatal Damage in Mice
Mol. Pharmacol.,
May 1, 2003;
63(5):
1169 - 1179.
[Abstract]
[Full Text]
[PDF]
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