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The Journal of Neuroscience, October 15, 2002, 22(20):9048-9052
The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins
Stephen C. Benoit1, Ellen L. Air1, Lique M. Coolen2, Richelle Strauss1, Alana Jackman3, Deborah J. Clegg1, Randy J. Seeley1, and Stephen C. Woods1 Departments of 1 Psychiatry and 2 Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Cincinnati, Ohio 45267, and 3 Procter & Gamble Pharmaceuticals, Mason, Ohio 45040
Like leptin, the pancreatic hormone insulin is an important adiposity signal to the brain. We report that the hypothalamic melanocortin system is an important target of the actions of insulin to regulate food intake and body weight. Hypothalamic neurons expressing insulin receptors were found to coexpress the melanocortin precursor molecule pro-opiomelanocortin (POMC), and administration of insulin into the third cerebral ventricle of fasted rats increased expression of POMC mRNA. Finally, a subthreshold dose of the melanocortin antagonist SHU-9119 prevented the reduction in food intake caused by third-ventricular insulin administration. These data suggest that the hypothalamic melanocortin system mediates the anorexic effects of central insulin, as well as of leptin.
Key words: insulin; melanocortins; POMC; food intake; obesity; leptin
Copyright © 2002 Society for Neuroscience 0270-6474/02/22209048-05$05.00/0
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