QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) A correction has been published Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (50) Citing Articles via Google Scholar Google Scholar Articles by Tessitore, A. Articles by Mattay, V. S. Search for Related Content PubMed PubMed Citation Articles by Tessitore, A. Articles by Mattay, V. S.

 Previous Article  |  Next Article 

The Journal of Neuroscience, October 15, 2002, 22(20):9099-9103

Dopamine Modulates the Response of the Human Amygdala: A Study in Parkinson's Disease

Alessandro Tessitore¹, Ahmad R. Hariri¹, Francesco Fera¹, William G. Smith¹, Thomas N. Chase², Thomas M. Hyde¹, Daniel R. Weinberger¹, and Venkata S. Mattay¹

¹ Clinical Brain Disorders Branch, National Institute of Mental Health, and ² Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892

In addition to classic motor signs and symptoms, Parkinson's disease (PD) is characterized by neuropsychological and emotional deficits, including a blunted emotional response. In the present study, we explored both the neural basis of abnormal emotional behavior in PD and the physiological effects of dopaminergic therapy on the response of the amygdala, a central structure in emotion processing. PD patients and matched normal controls (NCs) were studied with blood oxygenation level-dependent functional magnetic resonance imaging during a paradigm that involved perceptual processing of fearful stimuli. PD patients were studied twice, once during a relatively hypodopaminergic state (i.e., 12 hr after their last dose of dopamimetic treatment) and again during a dopamine-replete state. The imaging data revealed a robust bilateral amygdala response in NCs that was absent in PD patients during the hypodopaminergic state. Dopamine repletion partially restored this response in PD patients. Our results demonstrate an abnormal amygdala response in PD that may underlie the emotional deficits accompanying the disease. Furthermore, consistent with findings in experimental animal paradigms, our results provide in vivo evidence of the role of dopamine in modulating the response of the amygdala to sensory information in human subjects.

Key words: Parkinson's disease; dopamine; amygdala; modulating emotions; BOLD fMRI; depression

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22209099-05$05.00/0

This article has been cited by other articles:

				L. Strathearn, J. Li, P. Fonagy, and P. R. Montague What's in a Smile? Maternal Brain Responses to Infant Facial Cues Pediatrics, July 1, 2008; 122(1): 40 - 51. [Abstract] [Full Text] [PDF]

				K. L. Phan, M. Angstadt, J. Golden, I. Onyewuenyi, A. Popovska, and H. de Wit Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans J. Neurosci., March 5, 2008; 28(10): 2313 - 2319. [Abstract] [Full Text] [PDF]

				E. M. Drabant, A. R. Hariri, A. Meyer-Lindenberg, K. E. Munoz, V. S. Mattay, B. S. Kolachana, M. F. Egan, and D. R. Weinberger Catechol O-methyltransferase Val158Met Genotype and Neural Mechanisms Related to Affective Arousal and Regulation Arch Gen Psychiatry, December 1, 2006; 63(12): 1396 - 1406. [Abstract] [Full Text] [PDF]

				D. Bowers, K. Miller, A. Mikos, L. Kirsch-Darrow, U. Springer, H. Fernandez, K. Foote, and M. Okun Startling facts about emotion in Parkinson's disease: blunted reactivity to aversive stimuli Brain, December 1, 2006; 129(12): 3356 - 3365. [Abstract] [Full Text] [PDF]

				A. Suzuki, T. Hoshino, K. Shigemasu, and M. Kawamura Disgust-specific impairment of facial expression recognition in Parkinson's disease Brain, March 1, 2006; 129(3): 707 - 717. [Abstract] [Full Text] [PDF]

				A. R. Hariri, E. M. Drabant, K. E. Munoz, B. S. Kolachana, V. S. Mattay, M. F. Egan, and D. R. Weinberger A Susceptibility Gene for Affective Disorders and the Response of the Human Amygdala Arch Gen Psychiatry, February 1, 2005; 62(2): 146 - 152. [Abstract] [Full Text] [PDF]

				M. N. Smolka, G. Schumann, J. Wrase, S. M. Grusser, H. Flor, K. Mann, D. F. Braus, D. Goldman, C. Buchel, and A. Heinz Catechol-O-Methyltransferase val158met Genotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex J. Neurosci., January 26, 2005; 25(4): 836 - 842. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help