 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, November 15, 2002, 22(22):9932-9940
Theta-Frequency Synaptic Potentiation in CA1 In Vitro Distinguishes Cognitively Impaired from Unimpaired Aged Fischer 344 Rats
Geoffrey C. Tombaugh, Wayne B. Rowe, Ana R. Chow, Timothy H. Michael, and Gregory M. Rose Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645
Hippocampal-dependent learning and memory deficits have been well documented in aging rodents. The results of several recent studies have suggested that these deficits arise from weakened synaptic plasticity within the hippocampus. In the present study, we examined the relationship between hippocampal long-term potentiation (LTP) in vitro and spatial learning in aged (24-26 months) Fischer 344 rats. We found that LTP induced in the CA1 region using theta-frequency stimulation (5 Hz) is selectively impaired in slices from a subpopulation of aged rats that had shown poor spatial learning in the Morris water maze. LTP at 5 Hz in aged rats that did not show learning deficits was similar to that seen in young (4-6 months) controls. We also found that 5 Hz LTP amplitude strongly correlated with individual learning performance among aged rats. The difference in 5 Hz LTP magnitude among aged rats was not attributable to an altered response to 5 Hz stimulation or to differences in the NMDA receptor-mediated field EPSP. In addition, no performance-related differences in LTP were seen when LTP was induced with 30 or 70 Hz stimulation protocols. Finally, both 5 Hz LTP and spatial learning in learning-impaired rats were enhanced with the selective muscarinic M2 antagonist BIBN-99 (5,11-dihydro-8-chloro-11-[[4-[3-[(2,2-dimethyl-1-oxopentyl)ethylamino]propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one). These findings reinforce the idea that distinct types of hippocampal LTP offer mechanistic insight into age-associated cognitive decline.
Key words: hippocampus; aging; spatial learning; LTP; memory; NMDA receptor; muscarinic receptor
Copyright © 2002 Society for Neuroscience 0270-6474/02/22229932-09$05.00/0
This article has been cited by other articles:
K. Boric, P. Munoz, M. Gallagher, and A. Kirkwood
Potential Adaptive Function for Altered Long-Term Potentiation Mechanisms in Aging Hippocampus
J. Neurosci., August 6, 2008; 28(32): 8034 - 8039.
[Abstract] [Full Text] [PDF]
Z. Yang, M. Krause, G. Rao, B. L. McNaughton, and C. A. Barnes
Synaptic Commitment: Developmentally Regulated Reciprocal Changes in Hippocampal Granule Cell NMDA and AMPA Receptors Over the Lifespan
J Neurophysiol, June 1, 2008; 99(6): 2760 - 2768.
[Abstract] [Full Text] [PDF]
S. Sava and E. J. Markus
Activation of the Medial Septum Reverses Age-Related Hippocampal Encoding Deficits: A Place Field Analysis
J. Neurosci., February 20, 2008; 28(8): 1841 - 1853.
[Abstract] [Full Text] [PDF]
J. C. Lauterborn, C. S. Rex, E. Kramar, L. Y. Chen, V. Pandyarajan, G. Lynch, and C. M. Gall
Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome
J. Neurosci., October 3, 2007; 27(40): 10685 - 10694.
[Abstract] [Full Text] [PDF]
A. Kumar, J. S. Thinschmidt, T. C. Foster, and M. A. King
Aging Effects on the Limits and Stability of Long-Term Synaptic Potentiation and Depression in Rat Hippocampal Area CA1
J Neurophysiol, August 1, 2007; 98(2): 594 - 601.
[Abstract] [Full Text] [PDF]
W. B. Rowe, E. M. Blalock, K.-C. Chen, I. Kadish, D. Wang, J. E. Barrett, O. Thibault, N. M. Porter, G. M. Rose, and P. W. Landfield
Hippocampal Expression Analyses Reveal Selective Association of Immediate-Early, Neuroenergetic, and Myelinogenic Pathways with Cognitive Impairment in Aged Rats
J. Neurosci., March 21, 2007; 27(12): 3098 - 3110.
[Abstract] [Full Text] [PDF]
Y.-Y. Huang and E. R. Kandel
Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus.
Learn. Mem., May 1, 2006; 13(3): 298 - 306.
[Abstract] [Full Text] [PDF]
Y.-Y. Huang and E. R. Kandel
Theta frequency stimulation induces a local form of late phase LTP in the CA1 region of the hippocampus
Learn. Mem., November 1, 2005; 12(6): 587 - 593.
[Abstract] [Full Text] [PDF]
Y. Asaka, K. N. Mauldin, A. L. Griffin, M. A. Seager, E. Shurell, and S. D. Berry
Nonpharmacological amelioration of age-related learning deficits: The impact of hippocampal {theta}-triggered training
PNAS, September 13, 2005; 102(37): 13284 - 13288.
[Abstract] [Full Text] [PDF]
C. S. Rex, E. A. Kramar, L. L. Colgin, B. Lin, C. M. Gall, and G. Lynch
Long-Term Potentiation Is Impaired in Middle-Aged Rats: Regional Specificity and Reversal by Adenosine Receptor Antagonists
J. Neurosci., June 22, 2005; 25(25): 5956 - 5966.
[Abstract] [Full Text] [PDF]
G. F. Reis, M. B. Lee, A. S. Huang, and K. D. Parfitt
Adenylate Cyclase-Mediated Forms of Neuronal Plasticity in Hippocampal Area CA1 Are Reduced With Aging
J Neurophysiol, June 1, 2005; 93(6): 3381 - 3389.
[Abstract] [Full Text] [PDF]
L. Shi, M. C. Linville, E. W. Tucker, W. E. Sonntag, and J. K. Brunso-Bechtold
Differential Effects of Aging and Insulin-like Growth Factor-1 on Synapses in CA1 of Rat Hippocampus
Cereb Cortex, May 1, 2005; 15(5): 571 - 577.
[Abstract] [Full Text] [PDF]
G. C. Tombaugh, W. B. Rowe, and G. M. Rose
The Slow Afterhyperpolarization in Hippocampal CA1 Neurons Covaries with Spatial Learning Ability in Aged Fisher 344 Rats
J. Neurosci., March 9, 2005; 25(10): 2609 - 2616.
[Abstract] [Full Text] [PDF]
M. A. Bruno, P. B. S. Clarke, A. Seltzer, R. Quirion, K. Burgess, A. C. Cuello, and H. U. Saragovi
Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA
J. Neurosci., September 15, 2004; 24(37): 8009 - 8018.
[Abstract] [Full Text] [PDF]
M. M. Oh, A. G. Kuo, W. W. Wu, E. A. Sametsky, and J. F. Disterhoft
Watermaze Learning Enhances Excitability of CA1 Pyramidal Neurons
J Neurophysiol, October 1, 2003; 90(4): 2171 - 2179.
[Abstract] [Full Text] [PDF]
D. J. Froc, B. Eadie, A. M. Li, K. Wodtke, M. Tse, and B. R. Christie
Reduced Synaptic Plasticity in the Lateral Perforant Path Input to the Dentate Gyrus of Aged C57BL/6 Mice
J Neurophysiol, July 1, 2003; 90(1): 32 - 38.
[Abstract] [Full Text] [PDF]
G. F. Reis, M. B. Lee, A. S. Huang, and K. D. Parfitt
Adenylate Cyclase-Mediated Forms of Neuronal Plasticity in Hippocampal Area CA1 Are Reduced With Aging
J Neurophysiol, June 1, 2005; 93(6): 3381 - 3389.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|