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The Journal of Neuroscience, December 1, 2002, 22(23):10067-10071
BRIEF COMMUNICATION
Experience-Dependent Coincident Expression of the Effector
Immediate-Early Genes Arc and Homer 1a in
Hippocampal and Neocortical Neuronal Networks
Almira
Vazdarjanova1,
Bruce L.
McNaughton1, 2,
Carol A.
Barnes1, 2,
Paul F.
Worley3, and
John F.
Guzowski1
1 Arizona Research Laboratories, Division of Neural
Systems, Memory and Aging, and 2 Departments of Psychology
and Neurology, University of Arizona, Tucson, Arizona 85724-5115, and
3 Departments of Neuroscience and Neurology, John Hopkins
University, Baltimore, Maryland 21218
The transcription of the immediate-early genes Arc
and Homer 1a (H1a) is dynamically
regulated in response to synaptic activity; their protein products
function at the postsynaptic sites of excitatory synapses. Previous
studies demonstrate a role for Arc in the maintenance of
long-term potentiation and in memory consolidation processes and
indicate a role for H1a in modifying glutamatergic
signaling pathways. Using double-label fluorescence in
situ hybridization, we demonstrate that Arc and
H1a RNA expression is induced strongly in the same
neurons of rat hippocampus and neocortex after exploration of a novel
environment. These findings support the view that novel experience
activates a cell-specific genomic program and that Arc
and H1a may function in concert in the structural and
functional modifications of dendrites that lead to long-term changes in
synaptic efficacy.
Key words:
memory; learning; transcription; hippocampus; cortex; immediate-early; gene; Arc; Homer 1; dendrite; plasticity
Copyright © 2002 Society for Neuroscience 0270-6474/02/222310067-05$05.00/0
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