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The Journal of Neuroscience, December 15, 2002, 22(24):10731-10741

Nicotinic Receptors Mediate Changes in Spinal Motoneuron Development and Axonal Pathfinding in Embryonic Zebrafish Exposed to Nicotine

Kurt R. Svoboda^{1, 2}, Sukumar Vijayaraghavan², and Robert L. Tanguay³

¹ Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, ² School of Medicine, Department of Physiology and Biophysics, and ³ School of Pharmacy, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262

We show that transient exposure of embryonic zebrafish to nicotine delays the development of secondary spinal motoneurons. Furthermore, there is a long-lasting alteration in axonal pathfinding in secondary motoneurons that is not ameliorated by drug withdrawal. These effects of nicotine were reversed by mammalian nicotinic receptor antagonists. Coupled with these changes is a long-term alteration in swimming behavior. Our results show that transient embryonic exposure to nicotine leads to long-lasting effects on the vertebrate nervous system. These results also demonstrate that the zebrafish is a useful model to examine the effects of nicotine specifically, and drugs of abuse in general, on the development of the CNS in vertebrates.

Key words: nicotine; zebrafish; motoneurons; development; zn5; znS5

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Copyright © 2002 Society for Neuroscience  0270-6474/02/222410731-11$05.00/0

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