QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (48) Citing Articles via Google Scholar Google Scholar Articles by Laurent, A. Articles by Ropert, N. Search for Related Content PubMed PubMed Citation Articles by Laurent, A. Articles by Ropert, N.

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 1, 2002, 22(3):886-900

Activity-Dependent Presynaptic Effect of Serotonin 1B Receptors on the Somatosensory Thalamocortical Transmission in Neonatal Mice

Alban Laurent¹, Jean-Marc Goaillard¹, Olivier Cases², Cécile Lebrand², Patricia Gaspar², and Nicole Ropert¹

¹ Laboratoire de Neurophysiologie et Nouvelles Microscopies, Institut National de la Santé et de la Recherche Médicale (INSERM) EPI-0002, Ecole Supérieure de Physique et de Chimie Industrielle, 75231 Paris cedex 5, France, and ² INSERM U106, Bât. Pédiatrie, Hôpital Pitié Salpétrière, 75651 Paris cedex 13, France

The disruptive effect of excessive serotonin (5-HT) levels on the development of cortical sensory maps is mediated by 5-HT1B receptors, as shown in barrelless monoamine oxidase A knock-out mice, in which the additional inactivation of 5-HT1B receptors restores the barrels. However, it is unclear whether 5-HT1B receptors mediate their effect on barrel formation by a trophic action or an activity-dependent effect.

To test for a possible effect of 5-HT1B receptors on activity, we studied the influence of 5-HT on the thalamocortical (TC) synaptic transmission in layer IV cortical neurons. In TC slices of postnatal day 5 (P5)-P9 neonate mice, we show that 5-HT reduces monosynaptic TC EPSCs evoked by low-frequency internal capsule stimulation and relieves the short-term depression of the EPSC evoked by high-frequency stimulation. We provide evidence that 5-HT decreases the presynaptic release of glutamate: 5-HT reduces similarly the AMPA-kainate and NMDA components and the paired pulse depression of TC EPSCs. We show also that 5-HT1B receptors mediate exclusively the effect of 5-HT: first, the effect of 5-HT on the TC EPSC is correlated with the transient expression of 5-HT1B receptor mRNAs in the ventrobasal thalamic nucleus during postnatal development; second, it is mimicked by a 5-HT1B agonist; third, 5-HT has no effect in 5-HT1B receptor knock-out mice. Our results show that in the developing barrel field of the neonatal mice, 5-HT1B receptors mediate an activity-dependent regulation of the TC EPSC that could favor the propagation of high-frequency TC activity.

Key words: primary somatosensory cortex; barrel field; 5- hydroxytryptamine; serotonin; CP93129; 5-HT1B receptor; 5-HT1D receptor

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/223886-15$05.00/0

This article has been cited by other articles:

				A. Evrard and N. Ropert Early Development of the Thalamic Inhibitory Feedback Loop in the Primary Somatosensory System of the Newborn Mice J. Neurosci., August 5, 2009; 29(31): 9930 - 9940. [Abstract] [Full Text] [PDF]

				A. Watakabe, Y. Komatsu, O. Sadakane, S. Shimegi, T. Takahata, N. Higo, S. Tochitani, T. Hashikawa, T. Naito, H. Osaki, et al. Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses Cereb Cortex, August 1, 2009; 19(8): 1915 - 1928. [Abstract] [Full Text] [PDF]

				C. Takasaki, R. Okada, A. Mitani, M. Fukaya, M. Yamasaki, Y. Fujihara, T. Shirakawa, K. Tanaka, and M. Watanabe Glutamate Transporters Regulate Lesion-Induced Plasticity in the Developing Somatosensory Cortex J. Neurosci., May 7, 2008; 28(19): 4995 - 5006. [Abstract] [Full Text] [PDF]

				M. J. Albright, M. C. Weston, M. Inan, C. Rosenmund, and M. C. Crair Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice J Neurophysiol, September 1, 2007; 98(3): 1610 - 1625. [Abstract] [Full Text] [PDF]

				A. J. Borgdorff, J. F. A. Poulet, and C. C. H. Petersen Facilitating Sensory Responses in Developing Mouse Somatosensory Barrel Cortex J Neurophysiol, April 1, 2007; 97(4): 2992 - 3003. [Abstract] [Full Text] [PDF]

				M. Inan and M. C. Crair Development of Cortical Maps: Perspectives From the Barrel Cortex Neuroscientist, February 1, 2007; 13(1): 49 - 61. [Abstract] [PDF]

				M. F. Casanova Neuropathological and Genetic Findings in Autism: The Significance of a Putative Minicolumnopathy Neuroscientist, October 1, 2006; 12(5): 435 - 441. [Abstract] [PDF]

				R. F. Watson, R. M. Abdel-Majid, M. W. Barnett, B. S. Willis, A. Katsnelson, T. H. Gillingwater, G. S. McKnight, P. C. Kind, and P. E. Neumann Involvement of protein kinase A in patterning of the mouse somatosensory cortex. J. Neurosci., May 17, 2006; 26(20): 5393 - 5401. [Abstract] [Full Text] [PDF]

				Y. Rateau and N. Ropert Expression of a Functional Hyperpolarization-Activated Current (Ih) in the Mouse Nucleus Reticularis Thalami J Neurophysiol, May 1, 2006; 95(5): 3073 - 3085. [Abstract] [Full Text] [PDF]

				T. Esaki, M. Cook, K. Shimoji, D. L. Murphy, L. Sokoloff, and A. Holmes Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice PNAS, April 12, 2005; 102(15): 5582 - 5587. [Abstract] [Full Text] [PDF]

				S. Haj-Dahmane and R.-Y. Shen The Wake-Promoting Peptide Orexin-B Inhibits Glutamatergic Transmission to Dorsal Raphe Nucleus Serotonin Neurons through Retrograde Endocannabinoid Signaling J. Neurosci., January 26, 2005; 25(4): 896 - 905. [Abstract] [Full Text] [PDF]

				A. Rebsam, I. Seif, and P. Gaspar Dissociating Barrel Development and Lesion-Induced Plasticity in the Mouse Somatosensory Cortex J. Neurosci., January 19, 2005; 25(3): 706 - 710. [Abstract] [Full Text] [PDF]

				J. T. Porter and D. Nieves Presynaptic GABAB Receptors Modulate Thalamic Excitation of Inhibitory and Excitatory Neurons in the Mouse Barrel Cortex J Neurophysiol, November 1, 2004; 92(5): 2762 - 2770. [Abstract] [Full Text] [PDF]

				B. Voutsinos-Porche, G. Knott, K. Tanaka, C. Quairiaux, E. Welker, and G. Bonvento Glial Glutamate Transporters and Maturation of the Mouse Somatosensory Cortex Cereb Cortex, October 1, 2003; 13(10): 1110 - 1121. [Abstract] [Full Text] [PDF]

				Z.-w. Zhang Serotonin Induces Tonic Firing in Layer V Pyramidal Neurons of Rat Prefrontal Cortex during Postnatal Development J. Neurosci., April 15, 2003; 23(8): 3373 - 3384. [Abstract] [Full Text] [PDF]

				Z. Yang, I. Seif, and M. Armstrong-James Adult Experience-dependent Plasticity of S1 Barrel Cortex in the Normal and Monoamine Oxidase-A Knockout (Tg8) Mouse Cereb Cortex, December 1, 2002; 12(12): 1269 - 1279. [Abstract] [Full Text] [PDF]

				A. Rebsam, I. Seif, and P. Gaspar Refinement of Thalamocortical Arbors and Emergence of Barrel Domains in the Primary Somatosensory Cortex: A Study of Normal and Monoamine Oxidase A Knock-Out Mice J. Neurosci., October 1, 2002; 22(19): 8541 - 8552. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help