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The Journal of Neuroscience, February 15, 2002, 22(4):1443-1453

Blocking GABAergic Inhibition Increases Sensitivity to Sound Motion Cues in the Inferior Colliculus

David McAlpine¹ and Alan R. Palmer²

¹ Department of Physiology, University College London, London, WC1E 6BT, United Kingdom, and ² Medical Research Council Institute of Hearing Research, University of Nottingham, Nottingham, NG7 2RD, United Kingdom

Responses of low-frequency neurons in the inferior colliculus (IC) of anesthetized guinea pigs were recorded to interaural phase modulation (IPM) before, during, and after iontophoresis of bicuculline, an antagonist to the inhibitory neurotransmitter GABA. Sensitivity to the direction of virtual motion resulting from IPM is an emergent property of neurons at the level of the IC. One model to account for this emergent sensitivity depends on GABAergic inhibition. Blocking GABAergic inhibition with bicuculline substantially increased neuronal discharge rates and increased the extent to which neurons were sensitive to the apparent-motion cues of IPM. The effect of GABA blockade is consistent with the hypothesis that sensitivity to the motion cues of IPM results from a process of adaptation-of-excitation whereby the magnitude of the recent response history influences subsequent neuronal responsiveness. These results indicate that GABAergic inhibition strongly influences the context-dependent processing of low-frequency binaural signals in the IC.

Key words: inferior colliculus; binaural sensitivity; interaural phase differences; auditory motion; inhibition; adaptation-of-excitation

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Copyright © 2002 Society for Neuroscience  0270-6474/02/2241443-11$05.00/0

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