QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (40) Citing Articles via Google Scholar Google Scholar Articles by Partridge, J. G. Articles by Lovinger, D. M. Search for Related Content PubMed PubMed Citation Articles by Partridge, J. G. Articles by Lovinger, D. M.

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 1, 2002, 22(7):2541-2549

Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression

John G. Partridge¹, Subbu Apparsundaram², Greg A. Gerhardt², Jennifer Ronesi¹, and David M. Lovinger¹

¹ Vanderbilt University School of Medicine, Departments of Pharmacology, Molecular Physiology and Biophysics, and the Vanderbilt Center for Molecular Neuroscience, Nashville, Tennessee 37232-6600, and ² University of Kentucky Medical School, Department of Anatomy and Neurobiology, and the Center for Sensor Technology, Lexington, Kentucky 40536

The dorsal striatum participates in motor function and stimulus-response or "habit" learning. Acetylcholine (ACh) is a prominent neurotransmitter in the striatum and exerts part of its actions through nicotinic cholinergic receptors. Activation of these receptors has been associated with the enhancement of learning and certainly is instrumental in habitual use of nicotine. Nicotinic receptors have also been suggested to be a possible therapeutic target for disorders of the basal ganglia. In this report we show that the activation of nicotinic acetylcholine receptors in the dorsal striatum contributes to dopamine (DA)- and activity-dependent changes in synaptic efficacy. High-frequency activation of glutamatergic synapses onto striatal neurons results in a long-term depression (LTD) of synaptic efficacy that is dependent on the activation of dopamine receptors. This stimulation also produces robust increases in extracellular dopamine concentration as well as strong activation of cholinergic striatal interneurons. Antagonists of nicotinic acetylcholine receptors inhibit striatal LTD. However, on coapplication of dopamine reuptake inhibitors with nicotinic receptor antagonists, activity-induced striatal LTD is restored. Dopamine release is modulated by activation of nicotinic receptors in the dorsal striatum, and activation of nicotinic receptors during high-frequency synaptic activation appears to be capable of interacting with dopaminergic actions that lead to striatal LTD. Our results suggest that stimulation of mechanisms involved in striatal synaptic plasticity is an important role for striatal nicotinic acetylcholine receptors and that these mechanisms may contribute to the enhancement of learning and habit formation produced by nicotine intake.

Key words: striatum; synaptic plasticity; acetylcholine; dopamine; habit learning; drug addiction

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/2272541-09$05.00/0

This article has been cited by other articles:

				R. De Diego-Balaguer, M. Couette, G. Dolbeau, A. Durr, K. Youssov, and A.-C. Bachoud-Levi Striatal degeneration impairs language learning: evidence from Huntington's disease Brain, November 1, 2008; 131(11): 2870 - 2881. [Abstract] [Full Text] [PDF]

				J. Turchi, D. Buffalari, and M. Mishkin Double dissociation of pharmacologically induced deficits in visual recognition and visual discrimination learning Learn. Mem., August 6, 2008; 15(8): 565 - 568. [Abstract] [Full Text] [PDF]

				P. Bonsi, G. Martella, D. Cuomo, P. Platania, G. Sciamanna, G. Bernardi, J. Wess, and A. Pisani Loss of Muscarinic Autoreceptor Function Impairs Long-Term Depression But Not Long-Term Potentiation in the Striatum J. Neurosci., June 11, 2008; 28(24): 6258 - 6263. [Abstract] [Full Text] [PDF]

				V. Pawlak and J. N. D. Kerr Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity J. Neurosci., March 5, 2008; 28(10): 2435 - 2446. [Abstract] [Full Text] [PDF]

				S. M. Logan, J. G. Partridge, J. A. Matta, A. Buonanno, and S. Vicini Long-Lasting NMDA Receptor-Mediated EPSCs in Mouse Striatal Medium Spiny Neurons J Neurophysiol, November 1, 2007; 98(5): 2693 - 2704. [Abstract] [Full Text] [PDF]

				H. H. Yin and D. M. Lovinger Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling PNAS, May 23, 2006; 103(21): 8251 - 8256. [Abstract] [Full Text] [PDF]

				M. Quik, L. Chen, N. Parameswaran, X. Xie, J. W. Langston, and S. E. McCallum Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primates. J. Neurosci., April 26, 2006; 26(17): 4681 - 4689. [Abstract] [Full Text] [PDF]

				J. Ronesi and D. M. Lovinger Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat J. Physiol., January 1, 2005; 562(1): 245 - 256. [Abstract] [Full Text] [PDF]

				A. R. Tapper, S. L. McKinney, R. Nashmi, J. Schwarz, P. Deshpande, C. Labarca, P. Whiteaker, M. J. Marks, A. C. Collins, and H. A. Lester Nicotine Activation of {alpha}4* Receptors: Sufficient for Reward, Tolerance, and Sensitization Science, November 5, 2004; 306(5698): 1029 - 1032. [Abstract] [Full Text] [PDF]

				M. Simard and R. van Reekum The Acetylcholinesterase Inhibitors for Treatment of Cognitive and Behavioral Symptoms in Dementia With Lewy Bodies J Neuropsychiatry Clin Neurosci, November 1, 2004; 16(4): 409 - 425. [Abstract] [Full Text] [PDF]

				S. Middei, R. Geracitano, A. Caprioli, N. Mercuri, and M. Ammassari-Teule Preserved Fronto-Striatal Plasticity and Enhanced Procedural Learning in a Transgenic Mouse Model of Alzheimer's Disease Overexpressing Mutant hAPPswe Learn. Mem., July 1, 2004; 11(4): 447 - 452. [Abstract] [Full Text] [PDF]

				H. Yamada, N. Matsumoto, and M. Kimura Tonically Active Neurons in the Primate Caudate Nucleus and Putamen Differentially Encode Instructed Motivational Outcomes of Action J. Neurosci., April 7, 2004; 24(14): 3500 - 3510. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help