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The Journal of Neuroscience, April 15, 2002, 22(8):3117-3129

Ectopic Expression in the Giant Fiber System of Drosophila Reveals Distinct Roles for Roundabout (Robo), Robo2, and Robo3 in Dendritic Guidance and Synaptic Connectivity

Tanja A. Godenschwege¹, Julie H. Simpson², Xiaoliang Shan¹, Greg J. Bashaw², Corey S. Goodman², and Rodney K. Murphey¹

¹ Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, and ² Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720

The Roundabout (Robo) receptors have been intensively studied for their role in regulating axon guidance in the embryonic nervous system, whereas a role in dendritic guidance has not been explored. In the adult giant fiber system of Drosophila, we have revealed that ectopic Robo expression can regulate the growth and guidance of specific motor neuron dendrites, whereas Robo2 and Robo3 have no effect. We also show that the effect of Robo on dendritic guidance can be suppressed by Commissureless coexpression. Although we confirmed a role for all three Robo receptors in giant fiber axon guidance, the strong axon guidance alterations caused by overexpression of Robo2 or Robo3 have no effect on synaptic connectivity. In contrast, Robo overexpression in the giant fiber seems to directly interfere with synaptic function. We conclude that axon guidance, dendritic guidance, and synaptogenesis are separable processes and that the different Robo family members affect them distinctly.

Key words: axon; dendrites; guidance; giant fiber; Drosophila; roundabout; robo; slit; synapse; commissureless

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Copyright © 2002 Society for Neuroscience  0270-6474/02/2283117-13$05.00/0

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