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The Journal of Neuroscience, April 15, 2002, 22(8):3244-3250

The Rate of Intravenous Cocaine Administration Determines Susceptibility to Sensitization

Anne-Noël Samaha, Yilin Li, and Terry E. Robinson

Department of Psychology (Biopsychology Program), The University of Michigan, Ann Arbor, Michigan 48109-1109

The potential for addiction is thought to be greatest when drugs of abuse reach the brain rapidly, because this produces intense subjective pleasurable effects. However, the ability of drugs to induce forms of cellular plasticity related to behavioral sensitization may also contribute to addiction. Therefore, we studied the influence of rate of intravenous cocaine delivery on its ability to induce psychomotor sensitization. In one experiment, rotational behavior in rats with a unilateral 6-hydroxydopamine lesion was used as an index of psychomotor activation, and in a second experiment, locomotor activity in neurologically intact rats was used. Rapid (5-16 sec) intravenous infusions of cocaine induced robust psychomotor sensitization at all doses tested (0.5-2.0 mg/kg). Treatments given over 25 sec failed to induce sensitization at all doses tested. Treatments given over 50 or 100 sec induced sensitization only at the highest dose tested. Thus, the rate of intravenous cocaine delivery has profound effects on the ability of cocaine to induce psychomotor sensitization. This suggests that the temporal dynamics of drug delivery to the brain is a critical factor in the ability of cocaine to induce forms of neuronal plasticity that may contribute to addiction.

Key words: cocaine; psychomotor sensitization; behavioral sensitization; intravenous; rate of infusion; 6-hydroxydopamine lesion; rat

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Copyright © 2002 Society for Neuroscience  0270-6474/02/2283244-07$05.00/0

This article has been cited by other articles:

				S. Liu, R. P. Heitz, A. R. Sampson, W. Zhang, and C. W. Bradberry Evidence of Temporal Cortical Dysfunction in Rhesus Monkeys following Chronic Cocaine Self-Administration Cereb Cortex, September 1, 2008; 18(9): 2109 - 2116. [Abstract] [Full Text] [PDF]

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				A.-N. Samaha, N. Mallet, S. M. Ferguson, F. Gonon, and T. E. Robinson The Rate of Cocaine Administration Alters Gene Regulation and Behavioral Plasticity: Implications for Addiction J. Neurosci., July 14, 2004; 24(28): 6362 - 6370. [Abstract] [Full Text] [PDF]

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