 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, May 1, 2002, 22(9):3332-3337
MINI REVIEW
Behavioral Neurobiology of Alcohol Addiction: Recent Advances and ChallengesFriedbert Weiss1 and Linda J. Porrino2 1 Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, and 2 Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1083
Addictive behavior associated with alcoholism is characterized by compulsive preoccupation with obtaining alcohol, loss of control over consumption, and development of tolerance and dependence, as well as impaired social and occupational functioning. Like other addictive disorders, alcoholism is characterized by chronic vulnerability to relapse after cessation of drinking. To understand the factors that compel some individuals to drink excessively, alcohol research has focused on the identification of brain mechanisms that support the reinforcing actions of alcohol and the progression of changes in neural function induced by chronic ethanol consumption that lead to the development of dependence. More recently, increasing attention has been directed toward the understanding of neurobiological and environmental factors in susceptibility to relapse.
Copyright © 2002 Society for Neuroscience 0270-6474/02/2293332-06$05.00/0
This article has been cited by other articles:
T. C. Durazzo, S. Gazdzinski, P.-H. Yeh, and D. J. Meyerhoff
Combined Neuroimaging, Neurocognitive and Psychiatric Factors to Predict Alcohol Consumption Following Treatment for Alcohol Dependence
Alcohol Alcohol., November 1, 2008; 43(6): 683 - 691.
[Abstract] [Full Text] [PDF]
C. H. Yang, B. H. Lee, and S. H. Sohn
A Possible Mechanism Underlying the Effectiveness of Acupuncture in the Treatment of Drug Addiction
Evid. Based Complement. Altern. Med., September 1, 2008; 5(3): 257 - 266.
[Abstract] [Full Text] [PDF]
M. S. Bowers, F. W. Hopf, J. K. Chou, A. M. Guillory, S.-J. Chang, P. H. Janak, A. Bonci, and I. Diamond
Nucleus accumbens AGS3 expression drives ethanol seeking through G{beta}{gamma}
PNAS, August 26, 2008; 105(34): 12533 - 12538.
[Abstract] [Full Text] [PDF]
S. Carnicella, V. Kharazia, J. Jeanblanc, P. H. Janak, and D. Ron
GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse
PNAS, June 10, 2008; 105(23): 8114 - 8119.
[Abstract] [Full Text] [PDF]
T. Flatscher-Bader, N. Zuvela, N. Landis, and P.A. Wilce
Smoking and alcoholism target genes associated with plasticity and glutamate transmission in the human ventral tegmental area
Hum. Mol. Genet., January 1, 2008; 17(1): 38 - 51.
[Abstract] [Full Text] [PDF]
Y. Inoue, L. Yao, F. W. Hopf, P. Fan, Z. Jiang, A. Bonci, and I. Diamond
Nicotine and Ethanol Activate Protein Kinase A Synergistically via Gi beta{gamma} Subunits in Nucleus Accumbens/Ventral Tegmental Cocultures: The Role of Dopamine D1/D2 and Adenosine A2A Receptors
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 23 - 29.
[Abstract] [Full Text] [PDF]
J. M. Farook, D. J. Morrell, B. Lewis, J. M. Littleton, and S. Barron
Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster MICE
Alcohol Alcohol., July 1, 2007; 42(4): 296 - 300.
[Abstract] [Full Text] [PDF]
K. INGMAN, J. KUPILA, P. HYYTIA, and E. R. KORPI
EFFECTS OF ARIPIPRAZOLE ON ALCOHOL INTAKE IN AN ANIMAL MODEL OF HIGH-ALCOHOL DRINKING
Alcohol Alcohol., July 1, 2006; 41(4): 391 - 398.
[Abstract] [Full Text] [PDF]
T. Okamoto, M. T. Harnett, and H. Morikawa
Hyperpolarization-Activated Cation Current (Ih) Is an Ethanol Target in Midbrain Dopamine Neurons of Mice
J Neurophysiol, February 1, 2006; 95(2): 619 - 626.
[Abstract] [Full Text] [PDF]
Y.-K. LEE, S.-W. PARK, Y.-K. KIM, D.-J. KIM, J. JEONG, H. MYRICK, and Y.-H. KIM
EFFECTS OF NALTREXONE ON THE ETHANOL-INDUCED CHANGES IN THE RAT CENTRAL DOPAMINERGIC SYSTEM
Alcohol Alcohol., July 1, 2005; 40(4): 297 - 301.
[Abstract] [Full Text] [PDF]
C. H. Salmond, D. A. Chatfield, D. K. Menon, J. D. Pickard, and B. J. Sahakian
Cognitive sequelae of head injury: involvement of basal forebrain and associated structures
Brain, January 1, 2005; 128(1): 189 - 200.
[Abstract] [Full Text] [PDF]
B. A. Johnson, N. Ait-Daoud, F. Z. Akhtar, and J. Z. Ma
Oral Topiramate Reduces the Consequences of Drinking and Improves the Quality of Life of Alcohol-Dependent Individuals: A Randomized Controlled Trial
Arch Gen Psychiatry, September 1, 2004; 61(9): 905 - 912.
[Abstract] [Full Text] [PDF]
A. Scheurich, M. J. Muller, A. Szegedi, I. Anghelescu, C. Klawe, B. Lorch, B. Kappis, H.-G. Bialonski, S. Haas, and M. Hautzinger
NEUROPSYCHOLOGICAL STATUS OF ALCOHOL-DEPENDENT PATIENTS: INCREASED PERFORMANCE THROUGH GOAL-SETTING INSTRUCTIONS
Alcohol Alcohol., March 1, 2004; 39(2): 119 - 125.
[Abstract] [Full Text] [PDF]
R.-Y. Shen
Ethanol Withdrawal Reduces the Number of Spontaneously Active Ventral Tegmental Area Dopamine Neurons in Conscious Animals
J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 566 - 572.
[Abstract] [Full Text] [PDF]
J. Cami and M. Farre
Drug Addiction
N. Engl. J. Med., September 4, 2003; 349(10): 975 - 986.
[Full Text] [PDF]
M. Naassila, C. Ledent, and M. Daoust
Low Ethanol Sensitivity and Increased Ethanol Consumption in Mice Lacking Adenosine A2A Receptors
J. Neurosci., December 1, 2002; 22(23): 10487 - 10493.
[Abstract] [Full Text] [PDF]
F. J. White
A Behavioral/Systems Approach to the Neuroscience of Drug Addiction
J. Neurosci., May 1, 2002; 22(9): 3303 - 3305.
[Full Text] [PDF]
|
|
|
|
 |
|