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The Journal of Neuroscience, May 1, 2002, 22(9):3463-3472

Defective Proboscis Extension Response (DPR), a Member of the Ig Superfamily Required for the Gustatory Response to Salt

Makoto Nakamura^{1, 2}, David Baldwin³, Susannah Hannaford³, John Palka³, and Craig Montell¹

¹ Departments of Biological Chemistry and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, ² Division of Morphogenesis, Department of Developmental Biology, National Institute of Basic Biology, Okazaki 444-8585, Japan, and ³ Department of Zoology, University of Washington, Seattle, Washington 98195

Gustatory stimuli, such as sugar, induce a behavioral response in Drosophila that involves extension of the proboscis and consumption of the sugar-containing solution. Addition of salt to the sugar solution inhibits this behavioral response. However, the mechanisms and gene products involved in the salt aversion response have not been described. Here, we report the identification of a locus, defective proboscis extension response (dpr), that is required for salt aversion. dpr was expressed in a subset of primary neurons in the gustatory organs and encoded a protein with two Ig-like domains, a single putative transmembrane domain, and a short region C terminal to the transmembrane segment. In addition, DPR defines a large previously unknown group of 20 highly related Ig-containing proteins.

Key words: taste; Drosophila; immunoglobulin repeats; gustatory response; salt aversion; chemoreceptors

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Copyright © 2002 Society for Neuroscience  0270-6474/02/2293463-10$05.00/0

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