 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, May 1, 2002, 22(9):3553-3567
Patterns of Nogo mRNA and Protein Expression in the Developing and Adult Rat and After CNS Lesions
Andrea B. Huber, Oliver Weinmann, Christian Brösamle, Thomas Oertle, and Martin E. Schwab Brain Research Institute, University of Zurich, Zurich, 8057 Switzerland, and Department of Biology, Swiss Federal Institute of Technology, Zurich, 8057 Switzerland
Nogo-A is a neurite growth inhibitor involved in regenerative failure and restriction of structural plasticity in the adult CNS. Three major protein products (Nogo-A, -B, and -C) are derived from the nogo gene. Here we describe the embryonic and postnatal expression of the three Nogo isoforms in the rat by in situ hybridization and immunohistochemistry. Northern and Western blot analysis indicated that Nogo-A is predominantly expressed in the nervous system with lower levels also present in testis and heart. In CNS myelin, confocal and immunoelectron microscopy revealed that Nogo-A is expressed in oligodendrocyte cell bodies and processes and localized in the innermost adaxonal and outermost myelin membranes. Additionally, we find Nogo-A to be expressed by projection neurons, in particular during development, and by postmitotic cells in the developing cortex, spinal cord, and cerebellum. The expression levels of Nogo-A/B were not changed significantly after traumatic lesions to the cortex or spinal cord. Nogo-B showed widespread expression in the central and peripheral nervous systems and other peripheral tissues. Nogo-C was mainly found in skeletal muscle, but brain and heart were also found to express this isoform. The localization of Nogo-A in oligodendrocytes fits well with its role as a myelin-associated inhibitor of regenerative fiber growth and structural plasticity. However, expression of Nogo-A in other tissues and, in particular, in neurons and the widespread expression of the two shorter isoforms, Nogo-B and -C, suggest that the Nogo family of proteins might have function(s) additional to the neurite growth-inhibitory activity.
Key words: oligodendrocyte; myelin; neurite growth inhibition; development; spinal cord injury; regeneration
Copyright © 2002 Society for Neuroscience 0270-6474/02/2293553-15$05.00/0
This article has been cited by other articles:
V. Gil, Z. Bichler, J. K. Lee, O. Seira, F. Llorens, A. Bribian, R. Morales, E. Claverol-Tinture, E. Soriano, L. Sumoy, et al.
Developmental Expression of the Oligodendrocyte Myelin Glycoprotein in the Mouse Telencephalon
Cereb Cortex, November 5, 2009; (2009) bhp246v1.
[Abstract] [Full Text] [PDF]
Y. S. Yang, N. Y. Harel, and S. M. Strittmatter
Reticulon-4A (Nogo-A) Redistributes Protein Disulfide Isomerase to Protect Mice from SOD1-Dependent Amyotrophic Lateral Sclerosis
J. Neurosci., November 4, 2009; 29(44): 13850 - 13859.
[Abstract] [Full Text] [PDF]
X. Jiao, H. Chen, J. Chen, K. Herrup, B. L. Firestein, and M. Kiledjian
Modulation of Neuritogenesis by a Protein Implicated in X-Linked Mental Retardation
J. Neurosci., October 7, 2009; 29(40): 12419 - 12427.
[Abstract] [Full Text] [PDF]
L. Montani, B. Gerrits, P. Gehrig, A. Kempf, L. Dimou, B. Wollscheid, and M. E. Schwab
Neuronal Nogo-A Modulates Growth Cone Motility via Rho-GTP/LIMK1/Cofilin in the Unlesioned Adult Nervous System
J. Biol. Chem., April 17, 2009; 284(16): 10793 - 10807.
[Abstract] [Full Text] [PDF]
V. Pernet, S. Joly, F. Christ, L. Dimou, and M. E. Schwab
Nogo-A and Myelin-Associated Glycoprotein Differently Regulate Oligodendrocyte Maturation and Myelin Formation
J. Neurosci., July 16, 2008; 28(29): 7435 - 7444.
[Abstract] [Full Text] [PDF]
J. L. Cheatwood, A. J. Emerick, M. E. Schwab, and G. L. Kartje
Nogo-A Expression After Focal Ischemic Stroke in the Adult Rat
Stroke, July 1, 2008; 39(7): 2091 - 2098.
[Abstract] [Full Text] [PDF]
T. A. Bullard, T. L. Protack, F. Aguilar, S. Bagwe, H. T. Massey, and B. C. Blaxall
Identification of Nogo as a novel indicator of heart failure
Physiol Genomics, January 17, 2008; 32(2): 182 - 189.
[Abstract] [Full Text] [PDF]
S. Rossignol, M. Schwab, M. Schwartz, and M. G. Fehlings
Spinal Cord Injury: Time to Move?
J. Neurosci., October 31, 2007; 27(44): 11782 - 11792.
[Abstract] [Full Text] [PDF]
A. Mingorance-Le Meur, B. Zheng, E. Soriano, and J. A. del Rio
Involvement of the Myelin-Associated Inhibitor Nogo-A in Early Cortical Development and Neuronal Maturation
Cereb Cortex, October 1, 2007; 17(10): 2375 - 2386.
[Abstract] [Full Text] [PDF]
L. H. Shen, Y. Li, J. Chen, Y. Cui, C. Zhang, A. Kapke, M. Lu, S. Savant-Bhonsale, and M. Chopp
One-Year Follow-Up After Bone Marrow Stromal Cell Treatment in Middle-Aged Female Rats With Stroke
Stroke, July 1, 2007; 38(7): 2150 - 2156.
[Abstract] [Full Text] [PDF]
Z. Su, L. Cao, Y. Zhu, X. Liu, Z. Huang, A. Huang, and C. He
Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration
J. Cell Sci., June 1, 2007; 120(11): 1877 - 1887.
[Abstract] [Full Text] [PDF]
A. Jurewicz, M. Matysiak, C. S. Raine, and K. Selmaj
Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis
Neurology, January 23, 2007; 68(4): 283 - 287.
[Abstract] [Full Text] [PDF]
M. T Filbin
Recapitulate development to promote axonal regeneration: good or bad approach?
Phil Trans R Soc B, September 29, 2006; 361(1473): 1565 - 1574.
[Abstract] [Full Text] [PDF]
I. C Maier and M. E Schwab
Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity
Phil Trans R Soc B, September 29, 2006; 361(1473): 1611 - 1634.
[Abstract] [Full Text] [PDF]
C. M. Papadopoulos, S.-Y. Tsai, J. L. Cheatwood, M. R. Bollnow, B. E. Kolb, M. E. Schwab, and G. L. Kartje
Dendritic Plasticity in the Adult Rat Following Middle Cerebral Artery Occlusion and Nogo-A Neutralization
Cereb Cortex, April 1, 2006; 16(4): 529 - 536.
[Abstract] [Full Text] [PDF]
L. Corvetti and F. Rossi
Degradation of Chondroitin Sulfate Proteoglycans Induces Sprouting of Intact Purkinje Axons in the Cerebellum of the Adult Rat
J. Neurosci., August 3, 2005; 25(31): 7150 - 7158.
[Abstract] [Full Text] [PDF]
F. Hu, B. P. Liu, S. Budel, J. Liao, J. Chin, A. Fournier, and S. M. Strittmatter
Nogo-A Interacts with the Nogo-66 Receptor through Multiple Sites to Create an Isoform-Selective Subnanomolar Agonist
J. Neurosci., June 1, 2005; 25(22): 5298 - 5304.
[Abstract] [Full Text] [PDF]
D. A. Dodd, B. Niederoest, S. Bloechlinger, L. Dupuis, J.-P. Loeffler, and M. E. Schwab
Nogo-A, -B, and -C Are Found on the Cell Surface and Interact Together in Many Different Cell Types
J. Biol. Chem., April 1, 2005; 280(13): 12494 - 12502.
[Abstract] [Full Text] [PDF]
M. Xin, T. Yue, Z. Ma, F.-f. Wu, A. Gow, and Q. R. Lu
Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled in Olig1-Null Mice
J. Neurosci., February 9, 2005; 25(6): 1354 - 1365.
[Abstract] [Full Text] [PDF]
C. Moreau-Fauvarque, A. Kumanogoh, E. Camand, C. Jaillard, G. Barbin, I. Boquet, C. Love, E. Y. Jones, H. Kikutani, C. Lubetzki, et al.
The Transmembrane Semaphorin Sema4D/CD100, an Inhibitor of Axonal Growth, Is Expressed on Oligodendrocytes and Upregulated after CNS Lesion
J. Neurosci., October 8, 2003; 23(27): 9229 - 9239.
[Abstract] [Full Text] [PDF]
T. Oertle, M. E. van der Haar, C. E. Bandtlow, A. Robeva, P. Burfeind, A. Buss, A. B. Huber, M. Simonen, L. Schnell, C. Brosamle, et al.
Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions
J. Neurosci., July 2, 2003; 23(13): 5393 - 5406.
[Abstract] [Full Text] [PDF]
T. OERTLE, M. KLINGER, C. A. O. STUERMER, and M. E. SCHWAB
A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family
FASEB J, July 1, 2003; 17(10): 1238 - 1247.
[Abstract] [Full Text] [PDF]
S. Gianola, T. Savio, M. E. Schwab, and F. Rossi
Cell-Autonomous Mechanisms and Myelin-Associated Factors Contribute to the Development of Purkinje Axon Intracortical Plexus in the Rat Cerebellum
J. Neurosci., June 1, 2003; 23(11): 4613 - 4624.
[Abstract] [Full Text] [PDF]
P. J. Horner and F. H. Gage
Regeneration in the Adult and Aging Brain
Arch Neurol, November 1, 2002; 59(11): 1717 - 1720.
[Full Text] [PDF]
C. Pot, M. Simonen, O. Weinmann, L. Schnell, F. Christ, S. Stoeckle, P. Berger, T. Rulicke, U. Suter, and M. E. Schwab
Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury
J. Cell Biol., October 14, 2002; 159(1): 29 - 35.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|