QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (43) Citing Articles via Google Scholar Google Scholar Articles by Fischer, A. Articles by Radulovic, J. Search for Related Content PubMed PubMed Citation Articles by Fischer, A. Articles by Radulovic, J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, May 1, 2002, 22(9):3700-3707

Cyclin-Dependent Kinase 5 Is Required for Associative Learning

André Fischer, Farahnaz Sananbenesi, Christina Schrick, Joachim Spiess, and Jelena Radulovic

Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany

Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress. The Cdk5 protein is selectively induced in the fibers of septohippocampal cholinergic neurons but not in other regions of prominent Cdk5 production. This upregulation is accompanied by increased Cdk5 kinase activity, which is blocked completely by the Cdk5 inhibitor butyrolactone I. Microinjection of butyrolactone I into the lateral septum and hippocampus prevents the acquisition of conditioned context-dependent fear as well as its stress-induced facilitation. By demonstrating that a transient increase of Cdk5 activity within the septohippocampal system is required for associative learning, an important novel role of Cdk5 has been identified.

Key words: cyclin-dependent kinase 5; stress; fear conditioning; septum; hippocampus; cholinergic; mice

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/2293700-08$05.00/0

This article has been cited by other articles:

				K. P. Giese Novel Insights into the Beneficial and Detrimental Actions of Cdk5 Mol. Interv., October 1, 2007; 7(5): 246 - 248. [Abstract] [Full Text] [PDF]

				P. Juo, T. Harbaugh, G. Garriga, and J. M. Kaplan CDK-5 Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Cord of Caenorhabditis elegans Mol. Biol. Cell, October 1, 2007; 18(10): 3883 - 3893. [Abstract] [Full Text] [PDF]

				H. Kamei, T. Saito, M. Ozawa, Y. Fujita, A. Asada, J. A. Bibb, T. C. Saido, H. Sorimachi, and S.-i. Hisanaga Suppression of Calpain-dependent Cleavage of the CDK5 Activator p35 to p25 by Site-specific Phosphorylation J. Biol. Chem., January 19, 2007; 282(3): 1687 - 1694. [Abstract] [Full Text] [PDF]

				P. A. R. Manzanares, N. A. Isoardi, H. F. Carrer, and V. A. Molina Previous Stress Facilitates Fear Memory, Attenuates GABAergic Inhibition, and Increases Synaptic Plasticity in the Rat Basolateral Amygdala J. Neurosci., September 21, 2005; 25(38): 8725 - 8734. [Abstract] [Full Text] [PDF]

				F. Sananbenesi, A. Fischer, C. Schrick, J. Spiess, and J. Radulovic Mitogen-Activated Protein Kinase Signaling in the Hippocampus and Its Modulation by Corticotropin-Releasing Factor Receptor 2: A Possible Link between Stress and Fear Memory J. Neurosci., December 10, 2003; 23(36): 11436 - 11443. [Abstract] [Full Text] [PDF]

				S. Kesavapany, K.-F. Lau, S. Ackerley, S. J. Banner, S. J. A. Shemilt, J. D. Cooper, P. N. Leigh, C. E. Shaw, D. M. McLoughlin, and C. C. J. Miller Identification of a Novel, Membrane-Associated Neuronal Kinase, Cyclin-Dependent Kinase 5/p35-Regulated Kinase J. Neurosci., June 15, 2003; 23(12): 4975 - 4983. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help