QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 1, 2003, 23(11):4712-4716

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (92) Citing Articles via Google Scholar Google Scholar Articles by Adriani, W. Articles by Piazza, P. V. Search for Related Content PubMed PubMed Citation Articles by Adriani, W. Articles by Piazza, P. V.

 Previous Article  |  Next Article 

Evidence for Enhanced Neurobehavioral Vulnerability to Nicotine during Periadolescence in Rats

Walter Adriani,¹ Sabine Spijker,² Véronique Deroche-Gamonet,¹ Giovanni Laviola,³ Michel Le Moal,¹ August B. Smit,² and Pier Vincenzo Piazza¹

¹ Institut National de la Santé et de la Recherche Médicale U588, Université "V. Segalen", Bordeaux 2, Domaine de Carreire, 33077 Bordeaux, France, ² Department of Molecular and Cellular Neurobiology, Institute of Neurosciences, Faculty of Earth and Life Sciences, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands, and ³ Section of Behavioral Pathophysiology, Laboratory di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, 00161 Rome, Italy

Epidemiological studies indicate that there is an increased likelihood for the development of nicotine addiction when cigarette smoking starts early during adolescence. These observations suggest that adolescence could be a "critical" ontogenetic period, during which drugs of abuse have distinct effects responsible for the development of dependence later in life. We compared the long-term behavioral and molecular effects of repeated nicotine treatment during either periadolescence or postadolescence in rats. It was found that exposure to nicotine during periadolescence, but not a similar exposure in the postadolescent period, increased the intravenous self-administration of nicotine and the expression of distinct subunits of the ligand-gated acetylcholine receptor in adult animals. Both these changes indicated an increased sensitivity to the addictive properties of nicotine. In conclusion, adolescence seems to be a critical developmental period, characterized by enhanced neurobehavioral vulnerability to nicotine.

Key words: nicotine; adolescence; intravenous; self-administration; acetylcholine receptor; PCR

---

Received Dec. 5, 2002; revised Mar. 5, 2003; accepted Mar. 6, 2003.

This article has been cited by other articles:

				M. C. Fiore and T. B. Baker Stealing a March in the 21st Century: Accelerating Progress in the 100-Year War Against Tobacco Addiction in the United States Am J Public Health, July 1, 2009; 99(7): 1170 - 1175. [Abstract] [Full Text] [PDF]

				T. B. Baker, R. B. Weiss, D. Bolt, A. von Niederhausern, M. C. Fiore, D. M. Dunn, M. E. Piper, N. Matsunami, S. S. Smith, H. Coon, et al. Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes Nicotine Tob Res, July 1, 2009; 11(7): 785 - 796. [Abstract] [Full Text] [PDF]

				M. De Biasi and R. Salas Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal Experimental Biology and Medicine, August 1, 2008; 233(8): 917 - 929. [Abstract] [Full Text] [PDF]

				G. E. Swan and C. N. Lessov-Schlaggar The Genetics of Nicotine Addiction: Current Status and Future Directions ASCO Educational Book, January 1, 2008; 2008(1): 70 - 73. [Abstract] [Full Text] [PDF]

				D. Kota, B. R. Martin, S. E. Robinson, and M. I. Damaj Nicotine Dependence and Reward Differ between Adolescent and Adult Male Mice J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 399 - 407. [Abstract] [Full Text] [PDF]

				J. Littleton, S. Barron, M. Prendergast, and S. J. Nixon Smoking kills (alcoholics)! shouldn't we do something about it? Alcohol Alcohol., May 1, 2007; 42(3): 167 - 173. [Abstract] [Full Text] [PDF]

				A. F. Britton, R. E. Vann, and S. E. Robinson Perinatal Nicotine Exposure Eliminates Peak in Nicotinic Acetylcholine Receptor Response in Adolescent Rats J. Pharmacol. Exp. Ther., February 1, 2007; 320(2): 871 - 876. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help