QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 2, 2003, 23(13):5617-5626

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Preuss, T. Articles by Faber, D. S. Search for Related Content PubMed PubMed Citation Articles by Preuss, T. Articles by Faber, D. S.

 Previous Article  |  Next Article 

Central Cellular Mechanisms Underlying Temperature-Dependent Changes in the Goldfish Startle-Escape Behavior

Thomas Preuss and Donald S. Faber

Albert Einstein College of Medicine, Department of Neuroscience, New York, New York 10461

Activation of auditory afferents on the lateral dendrite of the Mauthner (M)-cell triggers an escape response (C-start) in goldfish. To study distinct behavioral changes and their physiological correlates on a cellular level we examined the effect of acute changes of temperature on M-cell membrane properties and intracellular responses to sound clicks and on C-start kinematics and behavior, focusing on threshold and initial escape direction, two properties determined on the M-cell level. Cooling slowed C-start motor performance, increasing response latency and decreasing peak velocity and peak acceleration, but increased the probability of triggering the escape. In addition, the likelihood of escapes in an inappropriate direction (e.g., responses toward the stimulus instead of away from it) increased at low temperatures. On a cellular level, cooling caused a distinct increase in input resistance of the M-cell and in the dendritic space constant for the auditory-evoked synaptic potentials. Moreover, cooling decreased the magnitude and delayed the onset of feedforward inhibition of the M-cell. These temperature-induced changes in the network and in the intrinsic M-cell properties combine to support behavioral hyperexcitability, but apparently also alter the directional decision-making process during an escape. More generally, our results illustrate that the balance between excitatory and inhibitory influences can determine the expression of a behavior and its modification and at the same time underline the significance of temperature for nervous system function and behavior.

Key words: dendritic cable properties; auditory-evoked response; excitatory/inhibitory balance; kinematics; neural temperature effects; escape behavior; neuroethology; Mauthner cell

---

Received Mar. 4, 2003; revised Apr. 7, 2003; accepted Apr. 9, 2003.

This article has been cited by other articles:

				K. T. Sillar and R. M. Robertson Thermal activation of escape swimming in post-hatching Xenopus laevis frog larvae J. Exp. Biol., August 1, 2009; 212(15): 2356 - 2364. [Abstract] [Full Text] [PDF]

				S. A. Weiss, T. Preuss, and D. S. Faber Phase Encoding in the Mauthner System: Implications in Left-Right Sound Source Discrimination J. Neurosci., March 18, 2009; 29(11): 3431 - 3441. [Abstract] [Full Text] [PDF]

				T. M. Szabo, T. Brookings, T. Preuss, and D. S. Faber Effects of Temperature Acclimation on a Central Neural Circuit and Its Behavioral Output J Neurophysiol, December 1, 2008; 100(6): 2997 - 3008. [Abstract] [Full Text] [PDF]

				S. A. Weiss, T. Preuss, and D. S. Faber A role of electrical inhibition in sensorimotor integration PNAS, November 18, 2008; 105(46): 18047 - 18052. [Abstract] [Full Text] [PDF]

				M. I. Latz, M. Bovard, V. VanDelinder, E. Segre, J. Rohr, and A. Groisman Bioluminescent response of individual dinoflagellate cells to hydrodynamic stress measured with millisecond resolution in a microfluidic device J. Exp. Biol., September 1, 2008; 211(17): 2865 - 2875. [Abstract] [Full Text] [PDF]

				H. Neumeister, T. M. Szabo, and T. Preuss Behavioral and Physiological Characterization of Sensorimotor Gating in the Goldfish Startle Response J Neurophysiol, March 1, 2008; 99(3): 1493 - 1502. [Abstract] [Full Text] [PDF]

				S. A. Weiss, S. J. Zottoli, S. C. Do, D. S. Faber, and T. Preuss Correlation of C-start behaviors with neural activity recorded from the hindbrain in free-swimming goldfish (Carassius auratus) J. Exp. Biol., December 1, 2006; 209(23): 4788 - 4801. [Abstract] [Full Text] [PDF]

				T. M. Szabo, S. A. Weiss, D. S. Faber, and T. Preuss Representation of Auditory Signals in the M-Cell: Role of Electrical Synapses J Neurophysiol, April 1, 2006; 95(4): 2617 - 2629. [Abstract] [Full Text] [PDF]

				T. Preuss, P. E. Osei-Bonsu, S. A. Weiss, C. Wang, and D. S. Faber Neural representation of object approach in a decision-making motor circuit. J. Neurosci., March 29, 2006; 26(13): 3454 - 3464. [Abstract] [Full Text] [PDF]

				E. H. van den Burg, R. R. Peeters, M. Verhoye, J. Meek, G. Flik, and A. Van der Linden Brain Responses to Ambient Temperature Fluctuations in Fish: Reduction of Blood Volume and Initiation of a Whole-Body Stress Response J Neurophysiol, May 1, 2005; 93(5): 2849 - 2855. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help