 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, July 23, 2003, 23(16):6460-6469
Previous Article | Next Article
Contribution of TWIK-Related Acid-Sensitive K+ Channel 1 (TASK1) and TASK3 Channels to the Control of Activity Modes in Thalamocortical Neurons
Sven G. Meuth, * Thomas Budde, * Tatyana Kanyshkova, Tilman Broicher, Thomas Munsch, andHans-Christian Pape Institute of Physiology, Otto-von-Guericke-Universität, D-39120 Magdeburg, Germany
The thalamocortical network is characterized by rhythmic burst activity during natural sleep and tonic single-spike activity during wakefulness. The change between these two activity modes is partially governed by transmitters acting on leak K+ currents in the thalamus, although the nature of the constituting ion channels is not yet known. In the present study, the contribution of members of the two-pore domain K+ channel family to the leak current was investigated using whole-cell patch-clamp techniques and molecular biological techniques. RT-PCR and in situ hybridization revealed the expression of TWIK-related acid-sensitive K+ channel 1 (TASK 1) and TASK3 channels in the rat dLGN. Voltage-clamp recordings of thalamocortical relay neurons in slice preparations demonstrated the existence of a current component sensitive to the TASK channel blocker bupivacaine, which reversed at the presumed K+ equilibrium potential, showed outward rectification, and contributed
40% to the standing outward current at depolarized values of the membrane potential (-28 mV). The pharmacological profile was indicative of TASK channels, in that the current was sensitive to changes in extracellular pH, reduced by muscarine and increased by halothane, and these effects were occluded by a near-maximal action of bupivacaine. Pharmacological manipulation of this current under current-clamp conditions resulted in a shift between burst and tonic firing modes. It is concluded that TASK1 and TASK3 channels contribute to the muscarine- and halothane-sensitive conductance in thalamocortical relay neurons, thereby contributing to the change in the activity mode of thalamocortical networks observed during the sleep-wake cycle and on application of inhalational anesthetics.
Key words: whole-cell patch clamp; RT-PCR; in situ hybridization; thalamic activity mode; anesthetics; muscarinic receptor; sleep-wake cycle
Received Apr. 11, 2003; revised May. 20, 2003; accepted May. 30, 2003.
This article has been cited by other articles:
A. Berna-Erro, A. Braun, R. Kraft, C. Kleinschnitz, M. K. Schuhmann, D. Stegner, T. Wultsch, J. Eilers, S. G. Meuth, G. Stoll, et al.
STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death
Sci. Signal., October 20, 2009; 2(93): ra67 - ra67.
[Abstract] [Full Text] [PDF]
D. S. J. Pang, C. J. Robledo, D. R. Carr, T. C. Gent, A. L. Vyssotski, A. Caley, A. Y. Zecharia, W. Wisden, S. G. Brickley, and N. P. Franks
An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action
PNAS, October 13, 2009; 106(41): 17546 - 17551.
[Abstract] [Full Text] [PDF]
S. Bittner, S. G. Meuth, K. Gobel, N. Melzer, A. M. Herrmann, O. J. Simon, A. Weishaupt, T. Budde, D. A. Bayliss, M. Bendszus, et al.
TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
Brain, September 1, 2009; 132(9): 2501 - 2516.
[Abstract] [Full Text] [PDF]
Z. Xiao, P.-Y. Deng, C. Yang, and S. Lei
Modulation of GABAergic Transmission by Muscarinic Receptors in the Entorhinal Cortex of Juvenile Rats
J Neurophysiol, August 1, 2009; 102(2): 659 - 669.
[Abstract] [Full Text] [PDF]
M. Zuzarte, K. Heusser, V. Renigunta, G. Schlichthorl, S. Rinne, E. Wischmeyer, J. Daut, B. Schwappach, and R. Preisig-Muller
Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins
J. Physiol., March 1, 2009; 587(5): 929 - 952.
[Abstract] [Full Text] [PDF]
Z. M. Khaliq and B. P. Bean
Dynamic, Nonlinear Feedback Regulation of Slow Pacemaking by A-Type Potassium Current in Ventral Tegmental Area Neurons
J. Neurosci., October 22, 2008; 28(43): 10905 - 10917.
[Abstract] [Full Text] [PDF]
J. A. Gonzalez, L. T. Jensen, L. Fugger, and D. Burdakov
Metabolism-Independent Sugar Sensing in Central Orexin Neurons
Diabetes, October 1, 2008; 57(10): 2569 - 2576.
[Abstract] [Full Text] [PDF]
R. H. Williams, H. Alexopoulos, L. T. Jensen, L. Fugger, and D. Burdakov
Adaptive sugar sensors in hypothalamic feeding circuits
PNAS, August 19, 2008; 105(33): 11975 - 11980.
[Abstract] [Full Text] [PDF]
S. G. Meuth, S. Bittner, P. Meuth, O. J. Simon, T. Budde, and H. Wiendl
TWIK-related Acid-sensitive K+ Channel 1 (TASK1) and TASK3 Critically Influence T Lymphocyte Effector Functions
J. Biol. Chem., May 23, 2008; 283(21): 14559 - 14570.
[Abstract] [Full Text] [PDF]
H. Toyoda, M. Saito, H. Sato, Y. Dempo, A. Ohashi, T. Hirai, Y. Maeda, T. Kaneko, and Y. Kang
cGMP Activates a pH-Sensitive Leak K+ Current in the Presumed Cholinergic Neuron of Basal Forebrain
J Neurophysiol, May 1, 2008; 99(5): 2126 - 2133.
[Abstract] [Full Text] [PDF]
D. K. Mulkey, E. M. Talley, R. L. Stornetta, A. R. Siegel, G. H. West, X. Chen, N. Sen, A. M. Mistry, P. G. Guyenet, and D. A. Bayliss
TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity
J. Neurosci., December 19, 2007; 27(51): 14049 - 14058.
[Abstract] [Full Text] [PDF]
C. Putzke, P. J. Hanley, G. Schlichthorl, R. Preisig-Muller, S. Rinne, M. Anetseder, R. Eckenhoff, C. Berkowitz, T. Vassiliou, H. Wulf, et al.
Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1319 - C1326.
[Abstract] [Full Text] [PDF]
S.-W. Ying, F. Jia, S. Y. Abbas, F. Hofmann, A. Ludwig, and P. A. Goldstein
Dendritic HCN2 Channels Constrain Glutamate-Driven Excitability in Reticular Thalamic Neurons
J. Neurosci., August 8, 2007; 27(32): 8719 - 8732.
[Abstract] [Full Text] [PDF]
R. H. Williams, L. T. Jensen, A. Verkhratsky, L. Fugger, and D. Burdakov
Control of hypothalamic orexin neurons by acid and CO2
PNAS, June 19, 2007; 104(25): 10685 - 10690.
[Abstract] [Full Text] [PDF]
M. J. Russo, E. Mugnaini, and M. Martina
Intrinsic properties and mechanisms of spontaneous firing in mouse cerebellar unipolar brush cells
J. Physiol., June 1, 2007; 581(2): 709 - 724.
[Abstract] [Full Text] [PDF]
A. Mathie
Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors
J. Physiol., January 15, 2007; 578(2): 377 - 385.
[Abstract] [Full Text] [PDF]
M. Zanzouri, I. Lauritzen, F. Duprat, M. Mazzuca, F. Lesage, M. Lazdunski, and A. Patel
Membrane Potential-regulated Transcription of the Resting K+ Conductance TASK-3 via the Calcineurin Pathway
J. Biol. Chem., September 29, 2006; 281(39): 28910 - 28918.
[Abstract] [Full Text] [PDF]
S. G. Meuth, T. Kanyshkova, P. Meuth, P. Landgraf, T. Munsch, A. Ludwig, F. Hofmann, H.-C. Pape, and T. Budde
Membrane Resting Potential of Thalamocortical Relay Neurons Is Shaped by the Interaction Among TASK3 and HCN2 Channels
J Neurophysiol, September 1, 2006; 96(3): 1517 - 1529.
[Abstract] [Full Text] [PDF]
J. R. Gibson, A. F. Bartley, and K. M. Huber
Role for the Subthreshold Currents ILeak and IH in the Homeostatic Control of Excitability in Neocortical Somatostatin-Positive Inhibitory Neurons
J Neurophysiol, July 1, 2006; 96(1): 420 - 432.
[Abstract] [Full Text] [PDF]
A.-M. Linden, M. I. Aller, E. Leppa, O. Vekovischeva, T. Aitta-aho, E. L. Veale, A. Mathie, P. Rosenberg, W. Wisden, and E. R. Korpi
The in Vivo Contributions of TASK-1-Containing Channels to the Actions of Inhalation Anesthetics, the {alpha}2 Adrenergic Sedative Dexmedetomidine, and Cannabinoid Agonists
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 615 - 626.
[Abstract] [Full Text] [PDF]
B. Musset, S. G. Meuth, G. X. Liu, C. Derst, S. Wegner, H.-C. Pape, T. Budde, R. Preisig-Muller, and J. Daut
Effects of divalent cations and spermine on the K+ channel TASK-3 and on the outward current in thalamic neurons
J. Physiol., May 1, 2006; 572(3): 639 - 657.
[Abstract] [Full Text] [PDF]
S. G. Meuth, M. I. Aller, T. Munsch, T. Schuhmacher, T. Seidenbecher, P. Meuth, C. Kleinschnitz, H.-C. Pape, H. Wiendl, W. Wisden, et al.
The Contribution of TWIK-Related Acid-Sensitive K+-Containing Channels to the Function of Dorsal Lateral Geniculate Thalamocortical Relay Neurons
Mol. Pharmacol., April 1, 2006; 69(4): 1468 - 1476.
[Abstract] [Full Text] [PDF]
K. M. Sanders and S. Don Koh
Two-pore-domain potassium channels in smooth muscles: new components of myogenic regulation
J. Physiol., January 1, 2006; 570(1): 37 - 43.
[Abstract] [Full Text] [PDF]
T. Budde, L. Caputi, T. Kanyshkova, R. Staak, C. Abrahamczik, T. Munsch, and H.-C. Pape
Impaired Regulation of Thalamic Pacemaker Channels through an Imbalance of Subunit Expression in Absence Epilepsy
J. Neurosci., October 26, 2005; 25(43): 9871 - 9882.
[Abstract] [Full Text] [PDF]
S. Taverna, T. Tkatch, A. E. Metz, and M. Martina
Differential Expression of TASK Channels between Horizontal Interneurons and Pyramidal Cells of Rat Hippocampus
J. Neurosci., October 5, 2005; 25(40): 9162 - 9170.
[Abstract] [Full Text] [PDF]
C. E Clarke, E. L Veale, P. J Green, H. J Meadows, and A. Mathie
Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc
J. Physiol., October 1, 2004; 560(1): 51 - 62.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|