 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, July 23, 2003, 23(16):6557-6566
Previous Article | Next Article
Two Forms of Synaptic Plasticity with Distinct Dependence on Age, Experience, and NMDA Receptor Subtype in Rat Visual Cortex
Yumiko Yoshimura,1 Tomohisa Ohmura,2 andYukio Komatsu1 1Department of Visual Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan, and 2Department of Ophthalmology, Nagoya University School of Medicine, Nagoya 466-8550, Japan
In visual cortex, NMDA receptor (NMDAR) properties depend primarily on NR2A and NR2B subunits, and NR2 subunit composition changes with age and visual experience. We examined the roles of these NR2 subunits in activity-dependent long-term modification of synaptic responses, which were evoked in layer 2/3 cells by stimulation of layer 4 in rat visual cortical slices. We used theta-burst stimulation (TBS) of presynaptic fibers or low-frequency stimulation paired with postsynaptic depolarization, which has been commonly used to induce NMDAR-dependent long-term potentiation (LTP) in visual cortex. In pyramidal cells, however, TBS produced long-term depression (LTD) at inhibitory synapses rather than LTP at excitatory synapses. This was observed in association with LTP of extracellular field potentials that reflect postsynaptic potentials in a population of cells (field-LTP). This result is inconsistent with the previous view that field-LTP reflects LTP of excitatory connections. However, pairing stimulation produced LTP at excitatory synapses of pyramidal cells frequently during development but rarely in adulthood. In contrast, inhibitory LTD and field-LTP occurred similarly in both developing and mature cortex. Experiments using NR2B selective and NR2 subunit nonselective NMDAR antagonists demonstrated that NR2A- and NR2B-containing NMDARs contribute selectively to inhibitory LTD-field-LTP and excitatory LTP, respectively. In addition, we found that the developmental decline in the NR2B component was paralleled by a decline in the incidence of excitatory LTP, and these declines were both prevented by dark rearing. These results implicate NR2 subunit composition in the regulation of neocortical plasticity and demonstrate differential subunit regulation at inhibitory and excitatory connections.
Key words: synaptic plasticity; long-term potentiation; long-term depression; NMDA receptor; NR2 subunit; visual cortex; development
Received Apr. 2, 2003; revised May. 16, 2003; accepted May. 23, 2003.
This article has been cited by other articles:
A. Banerjee, R. M. Meredith, A. Rodriguez-Moreno, S. B. Mierau, Y. P. Auberson, and O. Paulsen
Double Dissociation of Spike Timing-Dependent Potentiation and Depression by Subunit-Preferring NMDA Receptor Antagonists in Mouse Barrel Cortex
Cereb Cortex, December 1, 2009; 19(12): 2959 - 2969.
[Abstract] [Full Text] [PDF]
P. O. Kanold, Y. A. Kim, T. GrandPre, and C. J. Shatz
Co-regulation of ocular dominance plasticity and NMDA receptor subunit expression in glutamic acid decarboxylase-65 knock-out mice
J. Physiol., June 15, 2009; 587(12): 2857 - 2867.
[Abstract] [Full Text] [PDF]
M. C. Frey, R. Sprengel, and T. Nevian
Activity Pattern-Dependent Long-Term Potentiation in Neocortex and Hippocampus of GluA1 (GluR-A) Subunit-Deficient Mice
J. Neurosci., April 29, 2009; 29(17): 5587 - 5596.
[Abstract] [Full Text] [PDF]
H. Wang, G. G. Stradtman III, X.-J. Wang, and W.-J. Gao
A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
PNAS, October 28, 2008; 105(43): 16791 - 16796.
[Abstract] [Full Text] [PDF]
M. Sato and M. P. Stryker
Distinctive Features of Adult Ocular Dominance Plasticity
J. Neurosci., October 8, 2008; 28(41): 10278 - 10286.
[Abstract] [Full Text] [PDF]
J. de Marchena, A. C. Roberts, P. G. Middlebrooks, V. Valakh, K. Yashiro, L. R. Wilfley, and B. D. Philpot
NMDA Receptor Antagonists Reveal Age-Dependent Differences in the Properties of Visual Cortical Plasticity
J Neurophysiol, October 1, 2008; 100(4): 1936 - 1948.
[Abstract] [Full Text] [PDF]
R. Gentner, K. Wankerl, C. Reinsberger, D. Zeller, and J. Classen
Depression of Human Corticospinal Excitability Induced by Magnetic Theta-burst Stimulation: Evidence of Rapid Polarity-Reversing Metaplasticity
Cereb Cortex, September 1, 2008; 18(9): 2046 - 2053.
[Abstract] [Full Text] [PDF]
A. Sarihi, B. Jiang, A. Komaki, K. Sohya, Y. Yanagawa, and T. Tsumoto
Metabotropic Glutamate Receptor Type 5-Dependent Long-Term Potentiation of Excitatory Synapses on Fast-Spiking GABAergic Neurons in Mouse Visual Cortex
J. Neurosci., January 30, 2008; 28(5): 1224 - 1235.
[Abstract] [Full Text] [PDF]
B. Jiang, M. Trevino, and A. Kirkwood
Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex
J. Neurosci., September 5, 2007; 27(36): 9648 - 9652.
[Abstract] [Full Text] [PDF]
M. Tsanov and D. Manahan-Vaughan
The Adult Visual Cortex Expresses Dynamic Synaptic Plasticity That Is Driven by the Light/Dark Cycle
J. Neurosci., August 1, 2007; 27(31): 8414 - 8421.
[Abstract] [Full Text] [PDF]
K. Yamada, T. Inagaki, R. Funahashi, Y. Yoshimura, and Y. Komatsu
High-Frequency Stimulation Together with Adrenoceptor Activation Facilitates the Maintenance of Long-Term Potentiation at Visual Cortical Inhibitory Synapses
Cereb Cortex, September 1, 2006; 16(9): 1239 - 1248.
[Abstract] [Full Text] [PDF]
C. Weitlauf, Y. Honse, Y. P. Auberson, M. Mishina, D. M. Lovinger, and D. G. Winder
Activation of NR2A-Containing NMDA Receptors Is Not Obligatory for NMDA Receptor-Dependent Long-Term Potentiation
J. Neurosci., September 14, 2005; 25(37): 8386 - 8390.
[Abstract] [Full Text] [PDF]
A. Sobczyk, V. Scheuss, and K. Svoboda
NMDA Receptor Subunit-Dependent [Ca2+] Signaling in Individual Hippocampal Dendritic Spines
J. Neurosci., June 29, 2005; 25(26): 6037 - 6046.
[Abstract] [Full Text] [PDF]
K. Erreger, S. M Dravid, T. G Banke, D. J. A Wyllie, and S. F Traynelis
Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
J. Physiol., March 1, 2005; 563(2): 345 - 358.
[Abstract] [Full Text] [PDF]
T. A. Pham, S. J. Graham, S. Suzuki, A. Barco, E. R. Kandel, B. Gordon, and M. E. Lickey
A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB
Learn. Mem., November 1, 2004; 11(6): 738 - 747.
[Abstract] [Full Text] [PDF]
S. B. Mierau, R. M. Meredith, A. L. Upton, and O. Paulsen
Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex
PNAS, October 26, 2004; 101(43): 15518 - 15523.
[Abstract] [Full Text] [PDF]
S. G. Cull-Candy and D. N. Leszkiewicz
Role of Distinct NMDA Receptor Subtypes at Central Synapses
Sci. Signal., October 19, 2004; 2004(255): re16 - re16.
[Abstract] [Full Text] [PDF]
M. Huemmeke, U. T. Eysel, and T. Mittmann
Lesion-induced enhancement of LTP in rat visual cortex is mediated by NMDA receptors containing the NR2B subunit
J. Physiol., September 15, 2004; 559(3): 875 - 882.
[Abstract] [Full Text] [PDF]
L. Liu, T. P. Wong, M. F. Pozza, K. Lingenhoehl, Y. Wang, M. Sheng, Y. P. Auberson, and Y. T. Wang
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
Science, May 14, 2004; 304(5673): 1021 - 1024.
[Abstract] [Full Text] [PDF]
G. Kohr, V. Jensen, H. J. Koester, A. L. A. Mihaljevic, J. K. Utvik, A. Kvello, O. P. Ottersen, P. H. Seeburg, R. Sprengel, and O. Hvalby
Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction
J. Neurosci., November 26, 2003; 23(34): 10791 - 10799.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|