QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 23, 2003, 23(16):6651-6659

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (28) Citing Articles via Google Scholar Google Scholar Articles by Liu, G. Articles by Rao, Y. Search for Related Content PubMed PubMed Citation Articles by Liu, G. Articles by Rao, Y.

 Previous Article  |  Next Article 

Neuronal Migration from the Forebrain to the Olfactory Bulb Requires a New Attractant Persistent in the Olfactory Bulb

Guofa Liu and Yi Rao

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110

Interneurons in the olfactory bulb (OB) are generated not only in the developing embryo but also throughout the postnatal life of mammals from neuronal precursor cells migrating from the anterior subventricular zone (SVZa) of the mammalian forebrain. We discovered that the OB secretes a diffusible activity that attracts these neuronal precursor cells. The attractive activity is present in specific layers in the OB, including the glomerular layer but not the granule cell layer. The attractive activity and the neuronal responsiveness persist from embryonic through neonatal to adult stages. Removal of the rostral OB significantly reduces SVZa migration toward the OB, an effect that can be rescued by a transplant of the OB but not by that of the neocortex. The activity in the OB is not mimicked by the known attractants. These results provide an explanation for the continuous migration of SVZa neurons toward the OB, demonstrate an important role of the OB in neuronal migration, and reveal the existence of a new chemoattractant.

Key words: neuronal migration; olfactory bulb; attraction; precursor cells; olfaction; neural development

---

Received Dec. 2, 2002; revised May. 9, 2003; accepted May. 30, 2003.

This article has been cited by other articles:

				D. Garzotto, P. Giacobini, T. Crepaldi, A. Fasolo, and S. De Marchis Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling J. Neurosci., June 4, 2008; 28(23): 5901 - 5909. [Abstract] [Full Text] [PDF]

				A. Hienola, S. Tumova, E. Kulesskiy, and H. Rauvala N-syndecan deficiency impairs neural migration in brain J. Cell Biol., August 14, 2006; 174(4): 569 - 580. [Abstract] [Full Text] [PDF]

				K. L. Ng, J.-D. Li, M. Y. Cheng, F. M. Leslie, A. G. Lee, and Q.-Y. Zhou Dependence of Olfactory Bulb Neurogenesis on Prokineticin 2 Signaling Science, June 24, 2005; 308(5730): 1923 - 1927. [Abstract] [Full Text] [PDF]

				D. N. Abrous, M. Koehl, and M. Le Moal Adult Neurogenesis: From Precursors to Network and Physiology Physiol Rev, April 1, 2005; 85(2): 523 - 569. [Abstract] [Full Text] [PDF]

				P.-M. Lledo, G. Gheusi, and J.-D. Vincent Information Processing in the Mammalian Olfactory System Physiol Rev, January 1, 2005; 85(1): 281 - 317. [Abstract] [Full Text] [PDF]

				B. Slotnick, R. Cockerham, and E. Pickett Olfaction in Olfactory Bulbectomized Rats J. Neurosci., October 13, 2004; 24(41): 9195 - 9200. [Abstract] [Full Text] [PDF]

				K. T. Nguyen-Ba-Charvet, N. Picard-Riera, M. Tessier-Lavigne, A. Baron-Van Evercooren, C. Sotelo, and A. Chedotal Multiple Roles for Slits in the Control of Cell Migration in the Rostral Migratory Stream J. Neurosci., February 11, 2004; 24(6): 1497 - 1506. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help