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The Journal of Neuroscience, August 13, 2003, 23(19):7407-7411
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Abnormal Neural Synchrony in Schizophrenia
Kevin M. Spencer, Paul G. Nestor, Margaret A. Niznikiewicz, Dean F. Salisbury, Martha E. Shenton, andRobert W. McCarley Department of Psychiatry, Harvard Medical School/Veterans Affairs Boston Healthcare System, Brockton, Massachusetts 02301
Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry (particularly inhibitory interneurons) have been proposed as a basis for this disorder. We used measures of phase locking and phase coherence in the scalp-recorded electroencephalogram to examine the synchronization of neural circuits in schizophrenia. Compared with matched control subjects, schizophrenia patients demonstrated: (1) absence of the posterior component of the early visual gamma band response to Gestalt stimuli; (2) abnormalities in the topography, latency, and frequency of the anterior component of this response; (3) delayed onset of phase coherence changes; and (4) the pattern of anterior-posterior coherence increases in response to Gestalt stimuli found in controls was replaced by a pattern of interhemispheric coherence decreases in patients. These findings support the hypothesis that schizophrenia is associated with impaired neural circuitry demonstrated as a failure of gamma band synchronization, especially in the 40 Hz range.
Key words: schizophrenia; gamma band EEG; phase synchrony; wavelet analysis; visual perception; inhibitory interneurons
Received Mar. 10, 2003; revised Jun. 23, 2003; accepted Jun. 24, 2003.
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