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The Journal of Neuroscience, January 15, 2003, 23(2):373-376

BRIEF COMMUNICATION
Synaptic Activity of the AFD Neuron in Caenorhabditis elegans Correlates with Thermotactic Memory

Aravinthan D. T. Samuel, Ruwan A. Silva, and Venkatesh N. Murthy

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138

Thermotactic behavior in Caenorhabditis elegans is sensitive to both a worm's ambient temperature (T_amb) and its memory of the temperature of its cultivation (T_cult). The AFD neuron is part of a neural circuit that underlies thermotactic behavior. By monitoring the fluorescence of pH-sensitive green fluorescent protein localized to synaptic vesicles, we measured the rate of the synaptic release of AFD in worms cultivated at temperatures between 15 and 25°C, and subjected to fixed, ambient temperatures in the same range. We found that the rate of AFD synaptic release is high if either T_amb > T_cult or T_amb < T_cult, but AFD synaptic release is low if T_amb  T_cult. This suggests that AFD encodes a direct comparison between T_amb and T_cult.

Key words: thermotaxis; vesicle recycling; Caenorhabditis elegans; GFP; synaptic transmission; exocytosis

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Copyright © 2003 Society for Neuroscience  0270-6474/03/232373-04$05.00/0

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