 |
 Previous Article | Next Article 
The Journal of Neuroscience, January 15, 2003, 23(2):422-429
Loss of Kainate Receptor-Mediated Heterosynaptic Facilitation of
Mossy-Fiber Synapses in KA2 / Mice
Anis
Contractor1,
Andreas W.
Sailer1,
Melanie
Darstein1,
Cornelia
Maron1,
Jian
Xu1,
Geoffrey T.
Swanson2, and
Stephen F.
Heinemann1
1 Molecular Neurobiology Laboratory, The Salk Institute
for Biological Studies, La Jolla, California 92037, and
2 Department of Pharmacology and Toxicology, University of
Texas Medical Branch, Galveston, Texas 77555-1031
Multimeric assemblies of kainate (KA) receptor subunits form
glutamate-gated ion channels that mediate EPSCs and function as
presynaptic modulators of neurotransmitter release at some central
synapses. The KA2 subunit is a likely constituent of many neuronal
kainate receptors, because it is widely expressed in most neurons in
the CNS. We have studied the effect of genetic ablation of this
receptor subunit on synaptic transmission at the mossy-fiber-CA3
pyramidal cell synapse in hippocampal slices, where kainate receptors
are localized to both presynaptic and postsynaptic sites. We found that
both postsynaptic and presynaptic mossy-fiber kainate receptor function
is altered in neurons from KA2 / mice. The
presynaptic facilitatory autoreceptor, which modulates glutamate
release from mossy-fiber terminals, had a reduced affinity for
exogenous agonists and synaptic glutamate. Although presynaptic facilitation attributable to homosynaptic glutamate release was normal
at mossy-fiber synapses in KA2/ neurons,
heterosynaptic kainate receptor-mediated facilitation resulting from
the spillover of glutamate from CA3 collateral synapses was absent.
Consistent with a decrease in glutamate affinity of the receptor, the
half-decay of the postsynaptic kainate-mediated EPSC was shorter in the
knock-out mice. These results identify the KA2 subunit as a determinant
of kainate receptor function at presynaptic and postsynaptic
mossy-fiber kainate receptors.
Key words:
KA2 kainate receptor subunit; knock-out mice; presynaptic kainate receptors; CA3 pyramidal neurons; hippocampus; mossy-fiber
Copyright © 2003 Society for Neuroscience 0270-6474/03/232422-08$05.00/0
This article has been cited by other articles:
|
|
|
|
 
G. Dziewczapolski, C. M. Glogowski, E. Masliah, and S. F. Heinemann
Deletion of the {alpha}7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease
J. Neurosci.,
July 8, 2009;
29(27):
8805 - 8815.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sachidhanandam, C. Blanchet, Y. Jeantet, Y. H. Cho, and C. Mulle
Kainate Receptors Act as Conditional Amplifiers of Spike Transmission at Hippocampal Mossy Fiber Synapses
J. Neurosci.,
April 15, 2009;
29(15):
5000 - 5008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Miyata and K. Imoto
Contrary roles of kainate receptors in transmitter release at corticothalamic synapses onto thalamic relay and reticular neurons
J. Physiol.,
March 1, 2009;
587(5):
999 - 1012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Y. Sun, A. F. Bartley, and L. E. Dobrunz
Calcium-Permeable Presynaptic Kainate Receptors Involved in Excitatory Short-Term Facilitation Onto Somatostatin Interneurons During Natural Stimulus Patterns
J Neurophysiol,
February 1, 2009;
101(2):
1043 - 1055.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wondolowski and M. Frerking
Subunit-Dependent Postsynaptic Expression of Kainate Receptors on Hippocampal Interneurons in Area CA1
J. Neurosci.,
January 14, 2009;
29(2):
563 - 574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-L. Chen, H. Yu, W.-M. Yu, R. Pawlak, and S. Strickland
Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor
J. Cell Biol.,
December 29, 2008;
183(7):
1299 - 1313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Barberis, S. Sachidhanandam, and C. Mulle
GluR6/KA2 Kainate Receptors Mediate Slow-Deactivating Currents
J. Neurosci.,
June 18, 2008;
28(25):
6402 - 6406.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Mott, M. Benveniste, and R. J. Dingledine
pH-Dependent Inhibition of Kainate Receptors by Zinc
J. Neurosci.,
February 13, 2008;
28(7):
1659 - 1671.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Tam, V. Trembovler, V. Di Marzo, S. Petrosino, G. Leo, A. Alexandrovich, E. Regev, N. Casap, A. Shteyer, C. Ledent, et al.
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
FASEB J,
January 1, 2008;
22(1):
285 - 294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. Pinheiro, D. Perrais, F. Coussen, J. Barhanin, B. Bettler, J. R. Mann, J. O. Malva, S. F. Heinemann, and C. Mulle
GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses
PNAS,
July 17, 2007;
104(29):
12181 - 12186.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Rebola, S. Sachidhanandam, D. Perrais, R. A. Cunha, and C. Mulle
Short-Term Plasticity of Kainate Receptor-Mediated EPSCs Induced by NMDA Receptors at Hippocampal Mossy Fiber Synapses
J. Neurosci.,
April 11, 2007;
27(15):
3987 - 3993.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Saganich, B. E. Schroeder, V. Galvan, D. E. Bredesen, E. H. Koo, and S. F. Heinemann
Deficits in Synaptic Transmission and Learning in Amyloid Precursor Protein (APP) Transgenic Mice Require C-Terminal Cleavage of APP
J. Neurosci.,
December 27, 2006;
26(52):
13428 - 13436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Fisahn
Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool
J. Physiol.,
January 1, 2005;
562(1):
65 - 72.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Breustedt and D. Schmitz
Assessing the Role of GLUK5 and GLUK6 at Hippocampal Mossy Fiber Synapses
J. Neurosci.,
November 10, 2004;
24(45):
10093 - 10098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Fisahn, A. Contractor, R. D. Traub, E. H. Buhl, S. F. Heinemann, and C. J. McBain
Distinct Roles for the Kainate Receptor Subunits GluR5 and GluR6 in Kainate-Induced Hippocampal Gamma Oscillations
J. Neurosci.,
October 27, 2004;
24(43):
9658 - 9668.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ito, A. Contractor, and G. T. Swanson
Attenuated Plasticity of Postsynaptic Kainate Receptors in Hippocampal CA3 Pyramidal Neurons
J. Neurosci.,
July 7, 2004;
24(27):
6228 - 6236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rodriguez-Moreno and T. S. Sihra
Presynaptic kainate receptor facilitation of glutamate release involves protein kinase A in the rat hippocampus
J. Physiol.,
June 15, 2004;
557(3):
733 - 745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.-h. Youn and M. Randic
Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit
J. Physiol.,
March 15, 2004;
555(3):
683 - 698.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Jaskolski, F. Coussen, N. Nagarajan, E. Normand, C. Rosenmund, and C. Mulle
Subunit Composition and Alternative Splicing Regulate Membrane Delivery of Kainate Receptors
J. Neurosci.,
March 10, 2004;
24(10):
2506 - 2515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Darstein, R. S. Petralia, G. T. Swanson, R. J. Wenthold, and S. F. Heinemann
Distribution of Kainate Receptor Subunits at Hippocampal Mossy Fiber Synapses
J. Neurosci.,
September 3, 2003;
23(22):
8013 - 8019.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
