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The Journal of Neuroscience, August 27, 2003, 23(21):7897-7903

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Specific and Somatotopic Functional Magnetic Resonance Imaging Activation in the Trigeminal Ganglion by Brush and Noxious Heat

David Borsook, ^* Alexandre F. M. DaSilva, ^* Alex Ploghaus, and Lino Becerra ^*

Center for Pain Functional Neuroimaging and Therapy Research, Athinoula Martinos NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129

We used functional magnetic resonance imaging (fMRI) to assess activation in the trigeminal ganglion during innocuous mechanical (brush) and noxious thermal (46°C) stimulation of the face within the receptive fields of each of the three divisions of the trigeminal nerve in healthy volunteers. For both stimulus types, we observed signal changes only in the ipsilateral ganglion, and activation occurred somatotopically, as predicted by the known anatomical segregation of the neurons comprising the ophthalmic (V1), maxillary (V2), and mandibular (V3) divisions of the nerve. Signal decreased after brush stimuli and increased after the application of noxious heat. The abilities to detect somatotopic activation within the ganglion and to segregate non-noxious mechanical from noxious thermal stimuli suggest that fMRI will be valuable for measuring changes in the trigeminal ganglion in human models of neuropathic pain and in the clinical condition itself and may also be useful in the evaluation of pain therapies.

Key words: trigeminal ganglion; human; fMRI; pain; brush; heat

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Received March 10, 2003; revised June 19, 2003; accepted July 2, 2003.

This article has been cited by other articles:

				L. Becerra, S. Morris, S. Bazes, R. Gostic, S. Sherman, J. Gostic, G. Pendse, E. Moulton, S. Scrivani, D. Keith, et al. Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli. J. Neurosci., October 18, 2006; 26(42): 10646 - 10657. [Abstract] [Full Text] [PDF]

				S. C. Leiser and K. A. Moxon Relationship Between Physiological Response Type (RA and SA) and Vibrissal Receptive Field of Neurons Within the Rat Trigeminal Ganglion J Neurophysiol, May 1, 2006; 95(5): 3129 - 3145. [Abstract] [Full Text] [PDF]

				R. M. McAllen, M. Farrell, J. M. Johnson, D. Trevaks, L. Cole, M. J. McKinley, G. Jackson, D. A. Denton, and G. F. Egan Human medullary responses to cooling and rewarming the skin: A functional MRI study PNAS, January 17, 2006; 103(3): 809 - 813. [Abstract] [Full Text] [PDF]

				T Kamitani, Y Kuroiwa, and M Hidaka Isolated hypesthesia in the right V2 and V3 dermatomes after a midpontine infarction localised at an ipsilateral principal sensory trigeminal nucleus J. Neurol. Neurosurg. Psychiatry, October 1, 2004; 75(10): 1508 - 1509. [Full Text] [PDF]

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