WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, September 10, 2003, 23(23):8193-8203

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (30)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by James, J.
Right arrow Articles by Ahmad, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by James, J.
Right arrow Articles by Ahmad, I.

 Previous Article  |  Next Article 

In Vitro Generation of Early-Born Neurons from Late Retinal Progenitors

Jackson James,1 Ani V. Das,1 Sumitra Bhattacharya,1 David M. Chacko,2 Xing Zhao,1 and Iqbal Ahmad1

1Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198, and 2Grene Vision Group, Wichita, Kansas 67208

Evidence suggests that, as development ensues, the competence of neural progenitors is progressively altered, such that they become fated to give rise to neurons of a particular stage. Here, we demonstrate that late retinal progenitors can give rise to retinal ganglion cells (RGCs), an example of an early-born cell type in the retina. A subset of late retinal progenitors in vitro responds to cues that favor RGC differentiation by displaying markers characteristic of RGCs. In addition, mechanisms used during normal RGC differentiation are recruited by these cells toward their differentiation along RGC lineage. Our observations suggest that late neural progenitors may not be irreversibly fated but may appear as such under the constraints dictated by epigenetic cues.

Key words: retinal ganglion cells; Notch; stem cells/progenitors; differentiation; Ath5; Brn3b

Received April 29, 2003; revised July 2, 2003; accepted July 21, 2003.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. V. Das, J. James, S. Bhattacharya, A. N. Imbalzano, M. L. Antony, G. Hegde, X. Zhao, K. Mallya, F. Ahmad, E. Knudsen, et al.
SWI/SNF Chromatin Remodeling ATPase Brm Regulates the Differentiation of Early Retinal Stem Cells/Progenitors by Influencing Brn3b Expression and Notch Signaling
J. Biol. Chem., November 30, 2007; 282(48): 35187 - 35201.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Rothermel, K. Volpert, M. Burghardt, C. Lantzsch, A. A. Robitzki, and P. G. Layer
Knock-Down of GFR{alpha}4 Expression by RNA Interference Affects the Development of Retinal Cell Types in Three-Dimensional Histiotypic Retinal Spheres.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2716 - 2725.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Tabata, Y. Ouchi, H. Kamiya, T. Manabe, K.-i. Arai, and S. Watanabe
Specification of the Retinal Fate of Mouse Embryonic Stem Cells by Ectopic Expression of Rx/rax, a Homeobox Gene
Mol. Cell. Biol., May 15, 2004; 24(10): 4513 - 4521.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
L. A. Levin, R. Ritch, J. E. Richards, and T. Borras
Stem Cell Therapy for Ocular Disorders
Arch Ophthalmol, April 1, 2004; 122(4): 621 - 627.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-