WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Synaptic Systems Antibody Company
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, September 17, 2003, 23(24):8498-8505

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (45)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nikonenko, I.
Right arrow Articles by Muller, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nikonenko, I.
Right arrow Articles by Muller, D.

 Previous Article  |  Next Article 

Presynaptic Remodeling Contributes to Activity-Dependent Synaptogenesis

Irina Nikonenko, Pascal Jourdain, and Dominique Muller

Department of Pharmacology, University Medical Center, 1211 Geneva 4, Switzerland

Induction of long-term potentiation and application of short periods of anoxia/hypoglycemia result in the growth of dendritic filopodia and formation of new spines. Here we investigated whether these conditions also affected the morphology of presynaptic structures. Using confocal imaging of DiI-labeled axons, electron microscopy, and stereological analyses, we show that short anoxia/hypoglycemia and theta burst stimulation induced rapid, calcium-dependent growth of presynaptic filopodia-like protrusions and remodeling of presynaptic varicosities. Three-dimensional reconstruction of axonal outgrowths revealed that, within 30 min, they made contacts and triggered the formation of a postsynaptic density on the target cell. Interestingly, these axonal filopodia first established synapses with the dendritic shaft and later mostly with spines. They also contributed to the formation of multi-innervated spines. Because these presynaptic growth mechanisms depended on NMDA receptor activation, we investigated whether a diffusing messenger could be involved. We found that blockade of nitric oxide synthase prevented these changes, and conversely, a nitric oxide donor could reproduce them. A model is presented that proposes that activation of NMDA receptors and subsequent release of nitric oxide could trigger the growth of presynaptic filopodia, which, in turn, play an active role in synaptogenesis and spine formation.

Key words: anoxia/hypoglycemia; LTP; presynaptic morphology; nitric oxide; rat; hippocampus

Received March 31, 2003; revised July 8, 2003; accepted July 21, 2003.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J. Aoto, P. Ting, B. Maghsoodi, N. Xu, M. Henkemeyer, and L. Chen
Postsynaptic EphrinB3 Promotes Shaft Glutamatergic Synapse Formation
J. Neurosci., July 11, 2007; 27(28): 7508 - 7519.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Cesa, B. Scelfo, and P. Strata
Activity-Dependent Presynaptic and Postsynaptic Structural Plasticity in the Mature Cerebellum
J. Neurosci., April 25, 2007; 27(17): 4603 - 4611.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
S. Sapoznik, M. Ivenshitz, and M. Segal
Age-dependent glutamate induction of synaptic plasticity in cultured hippocampal neurons
Learn. Mem., November 1, 2006; 13(6): 719 - 727.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
S. Krueger and R. M. Fitzsimonds
Remodeling the plasticity debate: the presynaptic locus revisited.
Physiology, October 1, 2006; 21: 346 - 351.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Germuska, S. Saha, J. Fiala, and H. Barbas
Synaptic Distinction of Laminar-specific Prefrontal-temporal Pathways in Primates
Cereb Cortex, June 1, 2006; 16(6): 865 - 875.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F.-M. Lu and R. D. Hawkins
Presynaptic and postsynaptic Ca2+ and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons.
PNAS, March 14, 2006; 103(11): 4264 - 4269.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Apergis-Schoute, J. Debiec, V. Doyere, J. E. LeDoux, and G. E. Schafe
Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System
J. Neurosci., June 15, 2005; 25(24): 5730 - 5739.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. R. Sunico, F. Portillo, D. Gonzalez-Forero, and B. Moreno-Lopez
Nitric Oxide-Directed Synaptic Remodeling in the Adult Mammal CNS
J. Neurosci., February 9, 2005; 25(6): 1448 - 1458.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Duch and T. Mentel
Activity Affects Dendritic Shape and Synapse Elimination during Steroid Controlled Dendritic Retraction in Manduca sexta
J. Neurosci., November 3, 2004; 24(44): 9826 - 9837.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-