 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, September 24, 2003, 23(25):8743-8751
Previous Article | Next Article
Cellular/Molecular
Dual Effect of High-Frequency Stimulation on Subthalamic Neuron Activity
Liliana Garcia,1 Jacques Audin,1 Giampaolo D'Alessandro,3 Bernard Bioulac,1 andConstance Hammond2 1Laboratoire de Neurophysiologie (Centre National de la Recherche Scientifique UMR 5543), Université de Bordeaux 2, 33076 Bordeaux Cedex, France, 2Institut de Neurobiologie de la Méditerranée (Institut National de la Recherche Médicale U 29), BP 13, 13273 Marseille Cedex 9, France, and 3Department of Mathematics, University of Southampton, Southampton SO17 1BJ, United Kingdom
Although it is well known that high-frequency stimulation (HFS) of the subthalamic nucleus (STN) alleviates the cardinal symptoms of Parkinson's disease, the underlying mechanisms are not fully understood. We investigated the effect of stimulation from low to high frequencies on rat STN neurons in naive and dopamine-depleted slices using whole-cell, current-clamp techniques and on-line artifact suppression. Stimulation at 10 Hz evoked 10 Hz single spikes but did not significantly modify ongoing STN activity. In contrast, at therapeutically relevant frequencies (80-185 Hz), stimulation had a dual effect: it fully suppressed STN spontaneous activity and generated a robust pattern of recurrent bursts of spikes, with each spike being time-locked to a stimulus pulse. Neither the suppression of spontaneous activity nor the generation of spikes was prevented by the antagonists of the metabotropic and ionotropic receptors of glutamate and
-aminobutyric acid. Tetrodotoxin, the Na+ channel blocker, suppressed all HFS-evoked spikes, whereas nifedipin, an L-type Ca2+-channel blocker, abolished the membrane oscillations underlying bursts. Therefore, we conclude that HFS drives the STN neuronal activity by directly activating the neuronal membrane. We suggest that this pattern may remove the deleterious activity of the basal ganglia network in the parkinsonian state and drive target neurons to a high-frequency state of activity, dependent on the characteristics of STN efferent synapses and resonant properties of target membranes.
Key words: high-frequency stimulation; subthalamic nucleus; evoked bursting state; patch-clamp recordings; in vitro; gamma band frequency
Received April 14, 2003; revised July 29, 2003; accepted August 1, 2003.
This article has been cited by other articles:
C. Dejean, B. Hyland, and G. Arbuthnott
Cortical Effects of Subthalamic Stimulation Correlate with Behavioral Recovery from Dopamine Antagonist Induced Akinesia
Cereb Cortex, May 1, 2009; 19(5): 1055 - 1063.
[Abstract] [Full Text] [PDF]
K. W. McCairn and R. S. Turner
Deep Brain Stimulation of the Globus Pallidus Internus in the Parkinsonian Primate: Local Entrainment and Suppression of Low-Frequency Oscillations
J Neurophysiol, April 1, 2009; 101(4): 1941 - 1960.
[Abstract] [Full Text] [PDF]
P. Crenna, I. Carpinella, L. Lopiano, A. Marzegan, M. Rabuffetti, M. Rizzone, M. Lanotte, and M. Ferrarin
Influence of basal ganglia on upper limb locomotor synergies. Evidence from deep brain stimulation and L-DOPA treatment in Parkinson's disease
Brain, December 1, 2008; 131(12): 3410 - 3420.
[Abstract] [Full Text] [PDF]
R. Hilker, J. Voges, T. Weber, L. W. Kracht, J. Roggendorf, S. Baudrexel, M. Hoevels, V. Sturm, and W. D. Heiss
STN-DBS activates the target area in Parkinson disease: An FDG-PET study
Neurology, September 2, 2008; 71(10): 708 - 713.
[Abstract] [Full Text] [PDF]
D. S. Shin and P. L. Carlen
Enhanced Ih Depresses Rat Entopeduncular Nucleus Neuronal Activity From High-Frequency Stimulation or Raised Ke+
J Neurophysiol, May 1, 2008; 99(5): 2203 - 2219.
[Abstract] [Full Text] [PDF]
Y. Temel, L. J. Boothman, A. Blokland, P. J. Magill, H. W. M. Steinbusch, V. Visser-Vandewalle, and T. Sharp
Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus
PNAS, October 23, 2007; 104(43): 17087 - 17092.
[Abstract] [Full Text] [PDF]
J. K. H. Tang, E. Moro, N. Mahant, W. D. Hutchison, A. E. Lang, A. M. Lozano, and J. O. Dostrovsky
Neuronal Firing Rates and Patterns in the Globus Pallidus Internus of Patients With Cervical Dystonia Differ From Those With Parkinson's Disease
J Neurophysiol, August 1, 2007; 98(2): 720 - 729.
[Abstract] [Full Text] [PDF]
C. R. Lee and J. M. Tepper
A Calcium-Activated Nonselective Cation Conductance Underlies the Plateau Potential in Rat Substantia Nigra GABAergic Neurons
J. Neurosci., June 13, 2007; 27(24): 6531 - 6541.
[Abstract] [Full Text] [PDF]
K. Kaneda, T. Kita, and H. Kita
Repetitive Activation of Glutamatergic Inputs Evokes a Long-Lasting Excitation in Rat Globus Pallidus Neurons In Vitro
J Neurophysiol, January 1, 2007; 97(1): 121 - 133.
[Abstract] [Full Text] [PDF]
P. Shirvalkar, M. Seth, N. D. Schiff, and D. G. Herrera
Cognitive enhancement with central thalamic electrical stimulation
PNAS, November 7, 2006; 103(45): 17007 - 17012.
[Abstract] [Full Text] [PDF]
K. Witt, C. Daniels, J. Herzog, D. Lorenz, J. Volkmann, J. Reiff, M. Mehdorn, G. Deuschl, and P. Krack
Differential Effects of L-Dopa and Subthalamic Stimulation on Depressive Symptoms and Hedonic Tone in Parkinson's Disease
J Neuropsychiatry Clin Neurosci, August 1, 2006; 18(3): 397 - 401.
[Abstract] [Full Text] [PDF]
L. Garcia, G. D'Alessandro, P.-O. Fernagut, B. Bioulac, and C. Hammond
Impact of High-Frequency Stimulation Parameters on the Pattern of Discharge of Subthalamic Neurons
J Neurophysiol, December 1, 2005; 94(6): 3662 - 3669.
[Abstract] [Full Text] [PDF]
W. Meissner, A. Leblois, D. Hansel, B. Bioulac, C. E. Gross, A. Benazzouz, and T. Boraud
Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations
Brain, October 1, 2005; 128(10): 2372 - 2382.
[Abstract] [Full Text] [PDF]
B. Degos, J.-M. Deniau, A.-M. Thierry, J. Glowinski, L. Pezard, and N. Maurice
Neuroleptic-Induced Catalepsy: Electrophysiological Mechanisms of Functional Recovery Induced by High-Frequency Stimulation of the Subthalamic Nucleus
J. Neurosci., August 17, 2005; 25(33): 7687 - 7696.
[Abstract] [Full Text] [PDF]
F. Windels, C. Carcenac, A. Poupard, and M. Savasta
Pallidal Origin of GABA Release within the Substantia Nigra Pars Reticulata during High-Frequency Stimulation of the Subthalamic Nucleus
J. Neurosci., May 18, 2005; 25(20): 5079 - 5086.
[Abstract] [Full Text] [PDF]
M. Potter, M. Illert, R. Wenzelburger, G. Deuschl, and J. Volkmann
The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease
Neurology, October 12, 2004; 63(7): 1234 - 1239.
[Abstract] [Full Text] [PDF]
I. Bar-Gad, S. Elias, E. Vaadia, and H. Bergman
Complex Locking Rather Than Complete Cessation of Neuronal Activity in the Globus Pallidus of a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Primate in Response to Pallidal Microstimulation
J. Neurosci., August 18, 2004; 24(33): 7410 - 7419.
[Abstract] [Full Text] [PDF]
T. Anderson, B. Hu, Q. Pittman, and Z. H. T. Kiss
Mechanisms of deep brain stimulation: an intracellular study in rat thalamus
J. Physiol., August 15, 2004; 559(1): 301 - 313.
[Abstract] [Full Text] [PDF]
O. Detante, L. Vercueil, S. Thobois, E. Broussolle, N. Costes, F. Lavenne, S. Chabardes, D. Lebars, M. Vidailhet, A.-L. Benabid, et al.
Globus pallidus internus stimulation in primary generalized dystonia: a H215O PET study
Brain, August 1, 2004; 127(8): 1899 - 1908.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|