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The Journal of Neuroscience, October 8, 2003, 23(27):9133-9145

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Cellular/Molecular
sup-9, sup-10, and unc-93 May Encode Components of a Two-Pore K⁺ Channel that Coordinates Muscle Contraction in Caenorhabditis elegans

Ignacio Perez de la Cruz,¹ Joshua Z. Levin,¹ Claudia Cummins,² Philip Anderson,² and H. Robert Horvitz¹

¹Howard Hughes Medical Institute, Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139, and ²Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706

Genetic studies of sup-9, unc-93, and sup-10 strongly suggest that these genes encode components of a multi-subunit protein complex that coordinates muscle contraction in Caenorhabditis elegans. We cloned sup-9 and sup-10 and found that they encode a two-pore K⁺ channel and a novel transmembrane protein, respectively. We also found that UNC-93 and SUP-10 colocalize with SUP-9 within muscle cells, and that UNC-93 is a member of a novel multigene family that is conserved among C. elegans, Drosophila, and humans. Our results indicate that SUP-9 and perhaps other two-pore K⁺ channels function as multiprotein complexes, and that UNC-93 and SUP-10 likely define new classes of ion channel regulatory proteins.

Key words: C. elegans; two-pore; potassium [K⁺]; channel; muscle; mutant

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Received June 10, 2003; revised August 10, 2003; accepted August 13, 2003.

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