QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, October 15, 2003, 23(28):9297-9304

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (31) Citing Articles via Google Scholar Google Scholar Articles by Leung, L. S. Articles by Ma, J. Search for Related Content PubMed PubMed Citation Articles by Leung, L. S. Articles by Ma, J.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Cholinergic Activity Enhances Hippocampal Long-Term Potentiation in CA1 during Walking in Rats

L. Stan Leung,^1,2,5 Bixia Shen,^1,2 Nagalingam Rajakumar,^3,4,5 and Jingyi Ma^1,2

Departments of ¹Physiology and Pharmacology, ²Clinical Neurological Sciences, ³Psychiatry, and ⁴Anatomy and Cell Biology, and ⁵Neuroscience Program, The University of Western Ontario, London, Ontario, Canada N6A 5A5

Long-term potentiation (LTP) at the basal-dendritic synapses of CA1 pyramidal cells was induced by a single 200 Hz stimulation train (0.5-1 sec duration) in freely behaving rats during one of four behavioral states: awake-immobility (IMM), walking, slow-wave sleep (SWS), and rapid eye movement sleep (REM). Field EPSPs generated by basal-dendritic excitation of CA1 were recorded before and up to 1 d after the tetanus. After a tetanus during any behavioral state, basal-dendritic LTP was >170% of the baseline for the first hour after the tetanus and decayed to 120% 1 d after. LTP induced during walking was significantly larger than that induced during IMM, SWS, or REM, which had similar LTP magnitudes. To test the hypothesis that septohippocampal cholinergic activity enhanced LTP during walking as compared with IMM, rats were either pretreated with muscarinic cholinergic antagonist scopolamine or injected with IgG192-saporin in the medial septum to selectively lesion cholinergic septohippocampal neurons. Pretreatment with scopolamine decreased the LTP induced during walking but did not affect that induced during IMM, such that the difference between the LTP induced during walking and IMM was abolished after scopolamine. Rats injected with IgG192-saporin showed no difference in the LTP induced during walking and IMM, and scopolamine did not reduce the LTP during walking. In contrast, sham-lesion rats showed larger LTP induced during walking than IMM, and the LTP induced during walking was attenuated by scopolamine. This is the first demonstration of an enhancement of hippocampal LTP by physiologically activated cholinergic inputs.

Key words: long-term potentiation; CA1; basal dendrites; acetylcholine; theta rhythm; spatial learning

---

Received July 11, 2003; revised August 22, 2003; accepted August 27, 2003.

This article has been cited by other articles:

				L. S. Leung and P. Peloquin Cholinergic Modulation Differs between Basal and Apical Dendritic Excitation of Hippocampal CA1 Pyramidal Cells Cereb Cortex, November 19, 2009; (2009) bhp251v1. [Abstract] [Full Text] [PDF]

				J. T. R. Isaac, K. A. Buchanan, R. U. Muller, and J. R. Mellor Hippocampal Place Cell Firing Patterns Can Induce Long-Term Synaptic Plasticity In Vitro J. Neurosci., May 27, 2009; 29(21): 6840 - 6850. [Abstract] [Full Text] [PDF]

				H. C. Dringenberg, D. Oliveira, and D. Habib Predator (cat hair)-induced enhancement of hippocampal long-term potentiation in rats: Involvement of acetylcholine Learn. Mem., February 22, 2008; 15(3): 112 - 116. [Abstract] [Full Text] [PDF]

				H. C. Dringenberg, B. Hamze, A. Wilson, W. Speechley, and M.-C. Kuo Heterosynaptic Facilitation of In Vivo Thalamocortical Long-Term Potentiation in the Adult Rat Visual Cortex by Acetylcholine Cereb Cortex, April 1, 2007; 17(4): 839 - 848. [Abstract] [Full Text] [PDF]

				L. S. Leung and B. Shen Hippocampal CA1 kindling but not long-term potentiation disrupts spatial memory performance Learn. Mem., January 1, 2006; 13(1): 18 - 26. [Abstract] [Full Text] [PDF]

				B. Gisabella, V. Y. Bolshakov, and F. M. Benes Regulation of synaptic plasticity in a schizophrenia model PNAS, September 13, 2005; 102(37): 13301 - 13306. [Abstract] [Full Text] [PDF]

				F Manseau, M Danik, and S Williams A functional glutamatergic neurone network in the medial septum and diagonal band area J. Physiol., August 1, 2005; 566(3): 865 - 884. [Abstract] [Full Text] [PDF]

				D. Chaudhury, L. M. Wang, and C. S. Colwell Circadian Regulation of Hippocampal Long-Term Potentiation J Biol Rhythms, June 1, 2005; 20(3): 225 - 236. [Abstract] [PDF]

				L. L. Colgin, D. Kubota, Y. Jia, C. S. Rex, and G. Lynch Long-term potentiation is impaired in rat hippocampal slices that produce spontaneous sharp waves J. Physiol., August 1, 2004; 558(3): 953 - 961. [Abstract] [Full Text] [PDF]

				J. M. Hyman, B. P. Wyble, V. Goyal, C. A. Rossi, and M. E. Hasselmo Stimulation in Hippocampal Region CA1 in Behaving Rats Yields Long-Term Potentiation when Delivered to the Peak of Theta and Long-Term Depression when Delivered to the Trough J. Neurosci., December 17, 2003; 23(37): 11725 - 11731. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help