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The Journal of Neuroscience, February 1, 2003, 23(3):727

BRIEF COMMUNICATION
Transplantation of Olfactory Ensheathing Cells into Spinal Cord Lesions Restores Breathing and Climbing

Ying Li¹, Patrick Decherchi², and Geoffrey Raisman¹

¹ Norman and Sadie Lee Research Centre, Division of Neurobiology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, United Kingdom, and ² Faculté des Sciences du Sport de Marseille-Luminy, Unité Propre de Recherche de l'Enseignement Supérieur EA3285 Déterminants Physiologiques de l'Activité Physique-Institut Federatif de Recherche E. J. Marey, Université de la Méditerranée (Aix-Marseille II), 13288 Marseille cedex 09, France

One of the most devastating effects of damage to the upper spinal cord is the loss of the ability to breathe; patients suffering these injuries can be kept alive only with assisted ventilation. No known method for repairing these injuries exists. We report here the return of supraspinal control of breathing and major improvements in climbing after the application of a novel endogenous matrix transfer method. This method permits efficient transfer and retention of cultured adult rat olfactory ensheathing cells when transplanted into large lesions that destroy all tracts on one side at the upper cervical level of the adult rat spinal cord. This demonstrates that transplantation can produce simultaneous repair of two independent spinal functions.

Key words: spinal cord; breathing; olfactory ensheathing cells; repair; adult; transplantation

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Copyright © 2003 Society for Neuroscience  0270-6474/03/233727-05$05.00/0

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