QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (41) Citing Articles via Google Scholar Google Scholar Articles by Baufreton, J. Articles by Taupignon, A. Search for Related Content PubMed PubMed Citation Articles by Baufreton, J. Articles by Taupignon, A.

 Previous Article  |  Next Article 

The Journal of Neuroscience, February 1, 2003, 23(3):816

D5 (Not D1) Dopamine Receptors Potentiate Burst-Firing in Neurons of the Subthalamic Nucleus by Modulating an L-Type Calcium Conductance

Jérôme Baufreton¹, Maurice Garret¹, Alicia Rivera³, Adélaïda de la Calle³, François Gonon², Bernard Dufy¹, Bernard Bioulac¹, and Anne Taupignon¹

¹ Signalisation Normale et Pathologique, Unité Mixte de Recherche 5543, and ² Interactions Neuronales et Comportement, Unité Mixte de Recherche 5541, Université Victor Segalen, 33076 Bordeaux Cedex, France, and ³ Department of Cell Biology, Faculty of Sciences, University of Malaga, Teatinos 29071, Malaga, Spain

Dopamine is a crucial factor in basal ganglia functioning. In current models of basal ganglia, dopamine is postulated to act on striatal neurons. However, it may also act on the subthalamic nucleus (STN), a key nucleus in the basal ganglia circuit. The data presented here were obtained in brain slices using whole-cell patch clamp. They reveal that D5 dopamine receptors strengthen electrical activity in the subset of subthalamic neurons endowed with burst-firing capacity, resulting in longer discharges of spontaneous or evoked bursts.

To distinguish between D1 and D5 subtypes, the action of agonists in the D1/D5 receptor family was first investigated on rat subthalamic neurons. Single-cell reverse transcription-PCR profiling showed that burst-competent neurons only expressed D5 receptors. Accordingly, receptors localized in postsynaptic membranes within the STN were labeled by a D5-specific antibody. Second, agonists in the D1/D5 family were tested in mouse brain slices. It was found that these agonists were active in D1 receptor knock-out mice in a similar way to wild-type mice or rats. This proved that D5 rather than D1 receptors were involved. Pharmacological tools (dihydropyridines, -conotoxins, and calciseptine) were used to identify the target of D5 receptors as an L-type channel. This was reached via G-protein and protein kinase A. The action of dopamine on D5 receptors therefore shapes neuronal activity. It contributes to normal information processing in basal ganglia outside striatum. This finding may be useful in drug therapy for various disorders involving changes in STN activity, such as Parkinson's disease and related disorders.

Key words: dopamine; subthalamic nucleus; Parkinson's disease; burst firing; plateau potential; D5 dopamine receptor

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/233816-10$05.00/0

This article has been cited by other articles:

				U. Strauss, F.-W. Zhou, J. Henning, A. Battefeld, A. Wree, R. Kohling, S. J.-P. Haas, R. Benecke, A. Rolfs, and U. Gimsa Increasing Extracellular Potassium Results in Subthalamic Neuron Activity Resembling That Seen in a 6-Hydroxydopamine Lesion J Neurophysiol, June 1, 2008; 99(6): 2902 - 2915. [Abstract] [Full Text] [PDF]

				J. Baufreton and M. D. Bevan D2-like dopamine receptor-mediated modulation of activity-dependent plasticity at GABAergic synapses in the subthalamic nucleus J. Physiol., April 15, 2008; 586(8): 2121 - 2142. [Abstract] [Full Text] [PDF]

				S. Ramanathan, T. Tkatch, J. F. Atherton, C. J. Wilson, and M. D. Bevan D2-Like Dopamine Receptors Modulate SKCa Channel Function in Subthalamic Nucleus Neurons Through Inhibition of Cav2.2 Channels J Neurophysiol, February 1, 2008; 99(2): 442 - 459. [Abstract] [Full Text] [PDF]

				P. Belujon, E. Bezard, A. Taupignon, B. Bioulac, and A. Benazzouz Noradrenergic Modulation of Subthalamic Nucleus Activity: Behavioral and Electrophysiological Evidence in Intact and 6-Hydroxydopamine-Lesioned Rats J. Neurosci., September 5, 2007; 27(36): 9595 - 9606. [Abstract] [Full Text] [PDF]

				M. A. Kliem, N. T. Maidment, L. C. Ackerson, S. Chen, Y. Smith, and T. Wichmann Activation of Nigral and Pallidal Dopamine D1-Like Receptors Modulates Basal Ganglia Outflow in Monkeys J Neurophysiol, September 1, 2007; 98(3): 1489 - 1500. [Abstract] [Full Text] [PDF]

				C. R. Lee and J. M. Tepper A Calcium-Activated Nonselective Cation Conductance Underlies the Plateau Potential in Rat Substantia Nigra GABAergic Neurons J. Neurosci., June 13, 2007; 27(24): 6531 - 6541. [Abstract] [Full Text] [PDF]

				A. Hernandez, O. Ibanez-Sandoval, A. Sierra, R. Valdiosera, D. Tapia, V. Anaya, E. Galarraga, J. Bargas, and J. Aceves Control of the Subthalamic Innervation of the Rat Globus Pallidus by D2/3 and D4 Dopamine Receptors J Neurophysiol, December 1, 2006; 96(6): 2877 - 2888. [Abstract] [Full Text] [PDF]

				A. Gillies and D. Willshaw Membrane Channel Interactions Underlying Rat Subthalamic Projection Neuron Rhythmic and Bursting Activity J Neurophysiol, April 1, 2006; 95(4): 2352 - 2365. [Abstract] [Full Text] [PDF]

				O. Ibanez-Sandoval, A. Hernandez, B. Floran, E. Galarraga, D. Tapia, R. Valdiosera, D. Erlij, J. Aceves, and J. Bargas Control of the Subthalamic Innervation of Substantia Nigra Pars Reticulata by D1 and D2 Dopamine Receptors J Neurophysiol, March 1, 2006; 95(3): 1800 - 1811. [Abstract] [Full Text] [PDF]

				J. I. Kass and I. M. Mintz Silent plateau potentials, rhythmic bursts, and pacemaker firing: Three patterns of activity that coexist in quadristable subthalamic neurons PNAS, January 3, 2006; 103(1): 183 - 188. [Abstract] [Full Text] [PDF]

				J. Baufreton, Z.-T. Zhu, M. Garret, B. Bioulac, S. W. Johnson, and A. I. Taupignon Dopamine receptors set the pattern of activity generated in subthalamic neurons FASEB J, November 1, 2005; 19(13): 1771 - 1777. [Abstract] [Full Text] [PDF]

				Y. Yasoshima, N. Kai, S. Yoshida, S. Shiosaka, Y. Koyama, Y. Kayama, and K. Kobayashi Subthalamic Neurons Coordinate Basal Ganglia Function through Differential Neural Pathways J. Neurosci., August 24, 2005; 25(34): 7743 - 7753. [Abstract] [Full Text] [PDF]

				T. Otsuka, T. Abe, T. Tsukagawa, and W.-J. Song Conductance-Based Model of the Voltage-Dependent Generation of a Plateau Potential in Subthalamic Neurons J Neurophysiol, July 1, 2004; 92(1): 255 - 264. [Abstract] [Full Text] [PDF]

				C. E. Young and C. R. Yang Dopamine D1/D5 Receptor Modulates State-Dependent Switching of Soma-Dendritic Ca2+ Potentials via Differential Protein Kinase A and C Activation in Rat Prefrontal Cortical Neurons J. Neurosci., January 7, 2004; 24(1): 8 - 23. [Abstract] [Full Text] [PDF]

				N. E. Hallworth, C. J. Wilson, and M. D. Bevan Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels, through their Selective Coupling to Voltage-Gated Calcium Channels, Are Critical Determinants of the Precision, Pace, and Pattern of Action Potential Generation in Rat Subthalamic Nucleus Neurons In Vitro J. Neurosci., August 20, 2003; 23(20): 7525 - 7542. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help