QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 26, 2003, 23(34):10841-10851

This Article Full Text Full Text (PDF) Supplementary Table Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (83) Citing Articles via Google Scholar Google Scholar Articles by Newton, S. S. Articles by Duman, R. S. Search for Related Content PubMed PubMed Citation Articles by Newton, S. S. Articles by Duman, R. S.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors

Samuel S. Newton, Emily F. Collier, Joshua Hunsberger, David Adams, Rose Terwilliger, Emmanuel Selvanayagam, and Ronald S. Duman

Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508

Electroconvulsive seizure therapy (ECS) is a clinically proven treatment for depression and is often effective even in patients resistant to chemical antidepressants. However, the molecular mechanisms underlying the therapeutic efficacy of ECS are not fully understood. One theory that has gained attention is that ECS and other antidepressants increase the expression of select neurotrophic factors that could reverse or block the atrophy and cell loss resulting from stress and depression. To further address this topic, we examined the expression of other neurotrophic-growth factors and related signaling pathways in the hippocampus in response to ECS using a custom growth factor microarray chip. We report the regulation of several genes that are involved in growth factor and angiogenic-endothelial signaling, including neuritin, stem cell factor, vascular endothelial growth factor (VEGF), VGF (nonacronymic), cyclooxygenase-2, and tissue inhibitor of matrix metalloproteinase-1. Some of these, as well as other growth factors identified, including VEGF, basic fibroblast growth factor, and brain-derived neurotrophic factor, have roles in mediating neurogenesis and cell proliferation in the adult brain. We also examined gene expression in the choroid plexus and found several growth factors that are enriched in this vascular tissue as well as regulated by ECS. These data suggest that an amplification of growth factor signaling combined with angiogenic mechanisms could have an important role in the molecular action of ECS. This study demonstrates the applicability of custom-focused microarray technology in addressing hypothesis-driven questions regarding the action of antidepressants.

Key words: antidepressant; gene; growth factor; hippocampus; neurotrophic; seizure

---

Received July 3, 2003; revised September 26, 2003; accepted October 3, 2003.

This article has been cited by other articles:

				J. E. Ploski, V. J. Pierre, J. Smucny, K. Park, M. S. Monsey, K. A. Overeem, and G. E. Schafe The Activity-Regulated Cytoskeletal-Associated Protein (Arc/Arg3.1) Is Required for Memory Consolidation of Pavlovian Fear Conditioning in the Lateral Amygdala J. Neurosci., November 19, 2008; 28(47): 12383 - 12395. [Abstract] [Full Text] [PDF]

				X. L. Ang, D. P. Seeburg, M. Sheng, and J. W. Harper Regulation of Postsynaptic RapGAP SPAR by Polo-like Kinase 2 and the SCF{beta}-TRCP Ubiquitin Ligase in Hippocampal Neurons J. Biol. Chem., October 24, 2008; 283(43): 29424 - 29432. [Abstract] [Full Text] [PDF]

				O. Bozdagi, E. Rich, S. Tronel, M. Sadahiro, K. Patterson, M. L. Shapiro, C. M. Alberini, G. W. Huntley, and S. R. J. Salton The Neurotrophin-Inducible Gene Vgf Regulates Hippocampal Function and Behavior through a Brain-Derived Neurotrophic Factor-Dependent Mechanism J. Neurosci., September 24, 2008; 28(39): 9857 - 9869. [Abstract] [Full Text] [PDF]

				E. Segi-Nishida, J. L. Warner-Schmidt, and R. S. Duman Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus PNAS, August 12, 2008; 105(32): 11352 - 11357. [Abstract] [Full Text] [PDF]

				T. D. Perera, S. Park, and Y. Nemirovskaya Cognitive Role of Neurogenesis in Depression and Antidepressant Treatment Neuroscientist, August 1, 2008; 14(4): 326 - 338. [Abstract] [PDF]

				D. P. Seeburg and M. Sheng Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity J. Neurosci., June 25, 2008; 28(26): 6583 - 6591. [Abstract] [Full Text] [PDF]

				S. Thakker-Varia, J. J. Krol, J. Nettleton, P. M. Bilimoria, D. A. Bangasser, T. J. Shors, I. B. Black, and J. Alder The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus J. Neurosci., November 7, 2007; 27(45): 12156 - 12167. [Abstract] [Full Text] [PDF]

				M. Kedmi and A. Orr-Urtreger Expression changes in mouse brains following nicotine-induced seizures: the modulation of transcription factor networks Physiol Genomics, August 20, 2007; 30(3): 242 - 252. [Abstract] [Full Text] [PDF]

				V. Rigau, M. Morin, M.-C. Rousset, F. de Bock, A. Lebrun, P. Coubes, M.-C. Picot, M. Baldy-Moulinier, J. Bockaert, A. Crespel, et al. Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy Brain, July 1, 2007; 130(7): 1942 - 1956. [Abstract] [Full Text] [PDF]

				J. L. Warner-Schmidt and R. S. Duman VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants PNAS, March 13, 2007; 104(11): 4647 - 4652. [Abstract] [Full Text] [PDF]

				M. A. Bruno and A. C. Cuello Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade PNAS, April 25, 2006; 103(17): 6735 - 6740. [Abstract] [Full Text] [PDF]

				D. P. McCloskey, S. D. Croll, and H. E. Scharfman Depression of Synaptic Transmission by Vascular Endothelial Growth Factor in Adult Rat Hippocampus and Evidence for Increased Efficacy after Chronic Seizures J. Neurosci., September 28, 2005; 25(39): 8889 - 8897. [Abstract] [Full Text] [PDF]

				A. A. Pieper, X. Wu, T. W. Han, S. J. Estill, Q. Dang, L. C. Wu, S. Reece-Fincanon, C. A. Dudley, J. A. Richardson, D. J. Brat, et al. The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice PNAS, September 27, 2005; 102(39): 14052 - 14057. [Abstract] [Full Text] [PDF]

				D. N. Abrous, M. Koehl, and M. Le Moal Adult Neurogenesis: From Precursors to Network and Physiology Physiol Rev, April 1, 2005; 85(2): 523 - 569. [Abstract] [Full Text] [PDF]

				Y. Hao, T. Creson, L. Zhang, P. Li, F. Du, P. Yuan, T. D. Gould, H. K. Manji, and G. Chen Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis J. Neurosci., July 21, 2004; 24(29): 6590 - 6599. [Abstract] [Full Text] [PDF]

				N. M. Tsankova, A. Kumar, and E. J. Nestler Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures J. Neurosci., June 16, 2004; 24(24): 5603 - 5610. [Abstract] [Full Text] [PDF]

				C. A. Altar, P. Laeng, L. W. Jurata, J. A. Brockman, A. Lemire, J. Bullard, Y. V. Bukhman, T. A. Young, V. Charles, and M. G. Palfreyman Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways J. Neurosci., March 17, 2004; 24(11): 2667 - 2677. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help