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The Journal of Neuroscience, November 26, 2003, 23(34):10873-10878

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Cellular/Molecular
Molecular Basis for Ultraviolet Vision in Invertebrates

Ernesto Salcedo¹, Lijun Zheng,¹ Meridee Phistry,¹ Eve E. Bagg,¹ and Steven G. Britt^1,2

Departments of ¹Cell and Developmental Biology, and ²Ophthalmology, University of Colorado Health Sciences Center, Denver, Colorado 80262

Invertebrates are sensitive to a broad spectrum of light that ranges from UV to red. Color sensitivity in the UV plays an important role in foraging, navigation, and mate selection in both flying and terrestrial invertebrate animals. Here, we show that a single amino acid polymorphism is responsible for invertebrate UV vision. This residue (UV: lysine vs blue:asparagine or glutamate) corresponds to amino acid position glycine 90 (G90) in bovine rhodopsin, a site affected in autosomal dominant human congenital night blindness. Introduction of the positively charged lysine in invertebrates is likely to deprotonate the Schiff base chromophore and produce an UV visual pigment. This same position is responsible for regulating UV versus blue sensitivity in several bird species, suggesting that UV vision has arisen independently in invertebrate and vertebrate lineages by a similar molecular mechanism.

Key words: Drosophila; ERG (electroretinogram); photoreceptor; retina; vision; rhodopsin

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Received Sep 3, 2003; revised September 30, 2003; accepted October 1, 2003.

This article has been cited by other articles:

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