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The Journal of Neuroscience, December 10, 2003, 23(36):11402-11410

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Behavioral/Systems/Cognitive
Imaging Reveals Synaptic Targets of a Swim-Terminating Neuron in the Leech CNS

Adam L. Taylor,^1,2 Garrison W. Cottrell,¹ David Kleinfeld,³ and William B. Kristan, Jr²

¹Department of Computer Science and Engineering, ²Neurobiology Section, Division of Biological Sciences, and ³Department of Physics, University of California, San Diego, La Jolla, California 92093

In the leech, the command-like neuron called cell Tr2 is known to stop swimming, but the connections from cell Tr2 to the swim central pattern generator have not been identified. We used fluorescence resonance energy transfer voltage-sensitive dyes to identify three neurons that are synaptic targets of cell Tr2. We then used electrophysiological techniques to show that these connections are monosynaptic, chemical, and excitatory. Two of the novel targets, cell 256 and cell 54, terminate swimming when stimulated. These neurons are likely to mediate swim cessation caused by cell Tr2 activity, and thus play the role of intermediate control cells in the leech CNS.

Key words: connectivity; leech; swimming; swim termination; voltage-sensitive dye; fluorescence resonance energy transfer; coherence; command neuron

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Received Sep 1, 2003; revised October 8, 2003; accepted October 8, 2003.

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