 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, March 15, 2003, 23(6):2371
Regulation of Extracellular Signal-Regulated Kinase by Cannabinoids in Hippocampus
Pascal Derkinderen1, *, Emmanuel Valjent1, 2, *, Madeleine Toutant1, Jean-Christophe Corvol1, Hervé Enslen1, Catherine Ledent3, James Trzaskos4, Jocelyne Caboche2, and Jean-Antoine Girault1 1 Institut National de la Santé et de la Recherche Médicale/Université Pierre et Marie Curie U536, Institut du Fer à Moulin, Paris, France 75005, 2 Laboratoire de Neurobiologie des Processus Adaptatifs, Centre National de la Recherche Scientifique and Université Pierre et Marie Curie, UPMC Unité Mixte de Recherche 7102, Paris, France 75005, 3 Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, B1070, Brussels, Belgium, and 4 Bristol-Myers Squibb Company, Wilmington, Delaware 19880-0400
Endocannabinoids form a novel class of intercellular messengers, the functions of which include retrograde signaling in the brain and mediation or modulation of several types of synaptic plasticity. Yet, the signaling mechanisms and long-term effects of the stimulation of CB1 cannabinoid receptors (CB1-R) are poorly understood. We show that anandamide, 2-arachidonoyl-glycerol, and
9-tetrahydrocannabinol (THC) activated extracellular signal-regulated kinase (ERK) in hippocampal slices. In living mice, THC activated ERK in hippocampal neurons and induced its accumulation in the nuclei of pyramidal cells in CA1 and CA3. Both effects were attributable to stimulation of CB1-R and activation of MAP kinase/ERK kinase (MEK). In hippocampal slices, the stimulation of ERK was independent of phosphatidyl-inositol-3-kinase but was regulated by cAMP. The endocannabinoid-induced stimulation of ERK was lost in Fyn knock-out mice, in slices and in vivo, although it was insensitive to inhibitors of Src-family tyrosine kinases in vitro, suggesting a noncatalytic role of Fyn. Finally, the effects of cannabinoids on ERK activation were dependent on the activity of glutamate NMDA receptors in vivo, but not in hippocampal slices, indicating the existence of several pathways linking CB1-R to the ERK cascade. In vivo THC induced the expression of immediate-early genes products (c-Fos protein, Zif268, and BDNF mRNAs), and this induction was prevented by an inhibitor of MEK. The strong potential of cannabinoids for inducing long-term alterations in hippocampal neurons through the activation of the ERK pathway may be important for the physiological control of synaptic plasticity and for the general effects of THC in the context of drug abuse.
Key words: hippocampus; cannabinoids; 2-AG; anandamide; CB1-R; THC; LPA; ERK; phosphorylation; Fyn; immediate-early genes; c-Fos; Zif268; BDNF; slices; rat; mouse
* P.D. and E.V. contributed equally to this work.
Copyright © 2003 Society for Neuroscience 0270-6474/03/2362371-12$05.00/0
This article has been cited by other articles:
H.-C. Lin, S.-C. Mao, C.-L. Su, and P.-W. Gean
The Role of Prefrontal Cortex CB1 Receptors in the Modulation of Fear Memory
Cereb Cortex, May 13, 2008; (2008) bhn075v1.
[Abstract] [Full Text] [PDF]
D. A. Karanian, S. L. Karim, J. T. Wood, J. S. Williams, S. Lin, A. Makriyannis, and B. A. Bahr
Endocannabinoid Enhancement Protects against Kainic Acid-Induced Seizures and Associated Brain Damage
J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 1059 - 1066.
[Abstract] [Full Text] [PDF]
S. V. Siegmund, T. Qian, S. de Minicis, J. Harvey-White, G. Kunos, K. Y. Vinod, B. Hungund, and R. F. Schwabe
The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
FASEB J, September 1, 2007; 21(11): 2798 - 2806.
[Abstract] [Full Text] [PDF]
A.-G. Corbille, E. Valjent, G. Marsicano, C. Ledent, B. Lutz, D. Herve, and J.-A. Girault
Role of Cannabinoid Type 1 Receptors in Locomotor Activity and Striatal Signaling in Response to Psychostimulants
J. Neurosci., June 27, 2007; 27(26): 6937 - 6947.
[Abstract] [Full Text] [PDF]
P. Berghuis, A. M. Rajnicek, Y. M. Morozov, R. A. Ross, J. Mulder, G. M. Urban, K. Monory, G. Marsicano, M. Matteoli, A. Canty, et al.
Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity
Science, May 25, 2007; 316(5828): 1212 - 1216.
[Abstract] [Full Text] [PDF]
J. M. MILASIN, A. BUFFO, D. CARULLI, and P. STRATA
Intensive Remodeling of Purkinje Cell Spines after Climbing Fibers Deafferentation Does Not Involve MAPK and Akt Activation
Ann. N.Y. Acad. Sci., January 1, 2007; 1096(1): 230 - 238.
[Abstract] [Full Text] [PDF]
A. F. Hoffman, M. Oz, R. Yang, A. H. Lichtman, and C. R. Lupica
Opposing actions of chronic {Delta}9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
Learn. Mem., January 1, 2007; 14(1-2): 63 - 74.
[Abstract] [Full Text] [PDF]
E. S. Graham, N. Ball, E. L. Scotter, P. Narayan, M. Dragunow, and M. Glass
Induction of Krox-24 by Endogenous Cannabinoid Type 1 Receptors in Neuro2A Cells Is Mediated by the MEK-ERK MAPK Pathway and Is Suppressed by the Phosphatidylinositol 3-Kinase Pathway
J. Biol. Chem., September 29, 2006; 281(39): 29085 - 29095.
[Abstract] [Full Text] [PDF]
R. Tonini, S. Ciardo, M. Cerovic, T. Rubino, D. Parolaro, M. Mazzanti, and R. Zippel
ERK-Dependent Modulation of Cerebellar Synaptic Plasticity after Chronic {Delta}9-Tetrahydrocannabinol Exposure
J. Neurosci., May 24, 2006; 26(21): 5810 - 5818.
[Abstract] [Full Text] [PDF]
E. Valjent, B. Aubier, A.-G. Corbille, K. Brami-Cherrier, J. Caboche, P. Topilko, J.-A. Girault, and D. Herve
Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine.
J. Neurosci., May 3, 2006; 26(18): 4956 - 4960.
[Abstract] [Full Text] [PDF]
S. V. Siegmund, E. Seki, Y. Osawa, H. Uchinami, B. F. Cravatt, and R. F. Schwabe
Fatty Acid Amide Hydrolase Determines Anandamide-induced Cell Death in the Liver
J. Biol. Chem., April 14, 2006; 281(15): 10431 - 10438.
[Abstract] [Full Text] [PDF]
Y. Kawasaki, T. Kohno, and R.-R. Ji
Different Effects of Opioid and Cannabinoid Receptor Agonists on C-Fiber-Induced Extracellular Signal-Regulated Kinase Activation in Dorsal Horn Neurons in Normal and Spinal Nerve-Ligated Rats
J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 601 - 607.
[Abstract] [Full Text] [PDF]
K. Brami-Cherrier, E. Valjent, D. Herve, J. Darragh, J.-C. Corvol, C. Pages, A. J. Simon, J.-A. Girault, and J. Caboche
Parsing Molecular and Behavioral Effects of Cocaine in Mitogen- and Stress-Activated Protein Kinase-1-Deficient Mice
J. Neurosci., December 7, 2005; 25(49): 11444 - 11454.
[Abstract] [Full Text] [PDF]
D. A. Karanian, Q. B. Brown, A. Makriyannis, T. A. Kosten, and B. A. Bahr
Dual Modulation of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Protects against Excitotoxicity
J. Neurosci., August 24, 2005; 25(34): 7813 - 7820.
[Abstract] [Full Text] [PDF]
V. Pascoli, E. Valjent, A.-G. Corbille, J.-C. Corvol, J.-P. Tassin, J.-A. Girault, and D. Herve
cAMP and Extracellular Signal-Regulated Kinase Signaling in Response to D-Amphetamine and Methylphenidate in the Prefrontal Cortex in Vivo: Role of {beta}1-Adrenoceptors
Mol. Pharmacol., August 1, 2005; 68(2): 421 - 429.
[Abstract] [Full Text] [PDF]
Q. Zhao, Z. He, N. Chen, Y.-Y. Cho, F. Zhu, C. Lu, W.-y. Ma, A. M. Bode, and Z. Dong
2-Arachidonoylglycerol Stimulates Activator Protein-1-dependent Transcriptional Activity and Enhances Epidermal Growth Factor-induced Cell Transformation in JB6 P+ Cells
J. Biol. Chem., July 22, 2005; 280(29): 26735 - 26742.
[Abstract] [Full Text] [PDF]
S. H. Kim, S. J. Won, X. O. Mao, K. Jin, and D. A. Greenberg
Involvement of Protein Kinase A in Cannabinoid Receptor-Mediated Protection from Oxidative Neuronal Injury
J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 88 - 94.
[Abstract] [Full Text] [PDF]
N. Bayatti, H. Hermann, B. Lutz, and C. Behl
Corticotropin-Releasing Hormone-Mediated Induction of Intracellular Signaling Pathways and Brain-Derived Neurotrophic Factor Expression Is Inhibited by the Activation of the Endocannabinoid System
Endocrinology, March 1, 2005; 146(3): 1205 - 1213.
[Abstract] [Full Text] [PDF]
J.-C. Corvol, E. Valjent, M. Toutant, H. Enslen, T. Irinopoulou, S. Lev, D. Herve, and J.-A. Girault
Depolarization Activates ERK and Proline-rich Tyrosine Kinase 2 (PYK2) Independently in Different Cellular Compartments in Hippocampal Slices
J. Biol. Chem., January 7, 2005; 280(1): 660 - 668.
[Abstract] [Full Text] [PDF]
A. Cannich, C. T. Wotjak, K. Kamprath, H. Hermann, B. Lutz, and G. Marsicano
CB1 Cannabinoid Receptors Modulate Kinase and Phosphatase Activity During Extinction of Conditioned Fear in Mice
Learn. Mem., September 1, 2004; 11(5): 625 - 632.
[Abstract] [Full Text] [PDF]
K. Jin, L. Xie, S. H. Kim, S. Parmentier-Batteur, Y. Sun, X. O. Mao, J. Childs, and D. A. Greenberg
Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice
Mol. Pharmacol., August 1, 2004; 66(2): 204 - 208.
[Abstract] [Full Text] [PDF]
M. Alberich Jorda, N. Rayman, M. Tas, S. E. Verbakel, N. Battista, K. van Lom, B. Lowenberg, M. Maccarrone, and R. Delwel
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner
Blood, July 15, 2004; 104(2): 526 - 534.
[Abstract] [Full Text] [PDF]
H. Daniel, A. Rancillac, and F. Crepel
Mechanisms underlying cannabinoid inhibition of presynaptic Ca2+ influx at parallel fibre synapses of the rat cerebellum
J. Physiol., May 15, 2004; 557(1): 159 - 174.
[Abstract] [Full Text] [PDF]
M. I. Davis, J. Ronesi, and D. M. Lovinger
A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells
J. Biol. Chem., December 5, 2003; 278(49): 48973 - 48980.
[Abstract] [Full Text] [PDF]
X. Ren and I. Mody
{gamma}-Hydroxybutyrate Reduces Mitogen-activated Protein Kinase Phosphorylation via GABAB Receptor Activation in Mouse Frontal Cortex and Hippocampus
J. Biol. Chem., October 24, 2003; 278(43): 42006 - 42011.
[Abstract] [Full Text] [PDF]
G. Marsicano, S. Goodenough, K. Monory, H. Hermann, M. Eder, A. Cannich, S. C. Azad, M. G. Cascio, S. O. Gutierrez, M. van der Stelt, et al.
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
Science, October 3, 2003; 302(5642): 84 - 88.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|