QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Related articles in J. Neurosci. Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (68) Citing Articles via Google Scholar Google Scholar Articles by McQuillen, P. S. Articles by Ferriero, D. M. Search for Related Content PubMed PubMed Citation Articles by McQuillen, P. S. Articles by Ferriero, D. M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 15, 2003, 23(8):3308

Selective Vulnerability of Subplate Neurons after Early Neonatal Hypoxia-Ischemia

Patrick S. McQuillen¹, R. Ann Sheldon², Carla J. Shatz³, and Donna M. Ferriero^{1, 2}

Departments of ¹ Pediatrics and ² Neurology, University of California San Francisco Medical Center, San Francisco, California 94143-0106, and ³ Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115

Neonatal hypoxia-ischemia in the preterm human leads to selective injury to the subcortical developing white matter, which results in periventricular leukomalacia (PVL), a condition associated with abnormal neurodevelopment. Maturation-dependent vulnerability of late oligodendrocyte progenitors is thought to account for the cellular basis of this condition. A high frequency of cognitive and sensory deficits with decreasing gestational age suggests pervasive abnormalities of cortical development. In a neonatal rat model of hypoxic-ischemic injury that produces the characteristic pattern of subcortical injury associated with human PVL, selective subplate neuron death is seen. The premature subplate neuron death occurs after thalamic axons have reached their targets in cortex. Thus, as expected, thalamocortical connections form normally, including patterned connections to somatosensory cortex. However, deficits in motor function still occur, as in babies with PVL. Subplate neuron cell death in PVL provides another mechanism for abnormal neurodevelopment after neonatal hypoxia-ischemia.

Key words: periventricular leukomalacia; visual; cortex; development; premature infant; thalamocortical

---

Copyright © 2003 Society for Neuroscience  0270-6474/03/2383308-08$05.00/0

Related articles in J. Neurosci.:

This Week in The Journal

J. Neurosci. 2003 23: 0. [Abstract] [Full Text]  

This article has been cited by other articles:

				S. M. Manning, D. M. Talos, C. Zhou, D. B. Selip, H.-K. Park, C.-J. Park, J. J. Volpe, and F. E. Jensen NMDA Receptor Blockade with Memantine Attenuates White Matter Injury in a Rat Model of Periventricular Leukomalacia J. Neurosci., June 25, 2008; 28(26): 6670 - 6678. [Abstract] [Full Text] [PDF]

				V. Degos, G. Loron, J. Mantz, and P. Gressens Neuroprotective Strategies for the Neonatal Brain Anesth. Analg., June 1, 2008; 106(6): 1670 - 1680. [Abstract] [Full Text] [PDF]

				S. P. Miller, P. S. McQuillen, S. Hamrick, D. Xu, D. V. Glidden, N. Charlton, T. Karl, A. Azakie, D. M. Ferriero, A. J. Barkovich, et al. Abnormal Brain Development in Newborns with Congenital Heart Disease N. Engl. J. Med., November 8, 2007; 357(19): 1928 - 1938. [Abstract] [Full Text] [PDF]

				S. P Miller and P. S McQuillen Neurology of congenital heart disease: insight from brain imaging Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2007; 92(6): F435 - F437. [Full Text] [PDF]

				S. A. Back and S. P. Miller Cerebral White Matter Injury: The Changing Spectrum in Survivors of Preterm Birth NeoReviews, October 1, 2007; 8(10): e418 - e424. [Abstract] [Full Text] [PDF]

				L. Srinivasan, R. Dutta, S. J. Counsell, J. M. Allsop, J. P. Boardman, M. A. Rutherford, and A. D. Edwards Quantification of Deep Gray Matter in Preterm Infants at Term-Equivalent Age Using Manual Volumetry of 3-Tesla Magnetic Resonance Images Pediatrics, April 1, 2007; 119(4): 759 - 765. [Abstract] [Full Text] [PDF]

				M. Derrick, A. Drobyshevsky, X. Ji, and S. Tan A Model of Cerebral Palsy From Fetal Hypoxia-Ischemia Stroke, February 1, 2007; 38(2): 731 - 735. [Abstract] [Full Text] [PDF]

				M. V. Covey and S. W. Levison Pathophysiology of Perinatal Hypoxia-Ischemia and the Prospects for Repair from Endogenous and Exogenous Stem Cells NeoReviews, July 1, 2006; 7(7): e353 - e362. [Full Text] [PDF]

				A. Riddle, N. Ling Luo, M. Manese, D. J. Beardsley, L. Green, D. A. Rorvik, K. A. Kelly, C. H. Barlow, J. J. Kelly, A. R. Hohimer, et al. Spatial heterogeneity in oligodendrocyte lineage maturation and not cerebral blood flow predicts fetal ovine periventricular white matter injury. J. Neurosci., March 15, 2006; 26(11): 3045 - 3055. [Abstract] [Full Text] [PDF]

				R. D. Folkerth Neuropathologic Substrate of Cerebral Palsy J Child Neurol, December 1, 2005; 20(12): 940 - 949. [Abstract] [PDF]

				F. E. Jensen Role of Glutamate Receptors in Periventricular Leukomalacia J Child Neurol, December 1, 2005; 20(12): 950 - 959. [Abstract] [PDF]

				M. V. Johnston, D. M. Ferriero, S. J. Vannucci, and H. Hagberg Models of Cerebral Palsy: Which Ones Are Best? J Child Neurol, December 1, 2005; 20(12): 984 - 987. [PDF]

				J. J. Volpe Encephalopathy of Prematurity Includes Neuronal Abnormalities Pediatrics, July 1, 2005; 116(1): 221 - 225. [Full Text] [PDF]

				D. M. Ferriero Neonatal Brain Injury N. Engl. J. Med., November 4, 2004; 351(19): 1985 - 1995. [Full Text] [PDF]

				M. Derrick, N. L. Luo, J. C. Bregman, T. Jilling, X. Ji, K. Fisher, C. L. Gladson, D. J. Beardsley, G. Murdoch, S. A. Back, et al. Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy? J. Neurosci., January 7, 2004; 24(1): 24 - 34. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help