 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, April 15, 2003, 23(8):3446
Interactions with PDZ Proteins Are Required for L-Type Calcium Channels to Activate cAMP Response Element-Binding Protein-Dependent Gene Expression
Jason P. Weick, Rachel D. Groth, Ann L. Isaksen, and Paul G. Mermelstein Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455
After brief periods of heightened stimulation, calcium entry through L-type calcium channels leads to activation of the transcription factor cAMP response element-binding protein (CREB) and CRE-dependent transcription. Many of the details surrounding the mechanism by which L-type calcium channels are privileged in signaling to CREB, to the exclusion of other calcium entry pathways, has remained unclear. We hypothesized that the PDZ interaction sequence contained within the last four amino acids of the calcium channel
1C (CaV1.2) subunit [Val-Ser-Asn-Leu (VSNL)] is critical for L-type calcium channels (LTCs) to interact with the signaling machinery that triggers activity-dependent gene expression. To disrupt this interaction, hippocampal CA3-CA1 pyramidal neurons were transfected with DNA encoding for enhanced green fluorescent protein tethered to VSNL (EGFP-VSNL). EGFP-VSNL significantly attenuated L-type calcium channel-induced CREB phosphorylation and CRE-dependent transcription, although somatic calcium concentrations after stimulation remained unchanged. The effect of EGFP-VSNL was specific to the actions of L-type calcium channels, because CREB signaling after NMDA receptor stimulation remained intact. The importance of the PDZ interaction sequence was verified using dihydropyridine (DHP)-insensitive
Key words: NIL-16; CREB; NFAT; L-type calcium channel;
Copyright © 2003 Society for Neuroscience 0270-6474/03/2383446-11$05.00/0
This article has been cited by other articles:
M. J. Ferragamo, J. L. Reinardy, and S. A. Thayer
Ca2+-Dependent, Stimulus-Specific Modulation of the Plasma Membrane Ca2+ Pump in Hippocampal Neurons
J Neurophysiol, May 1, 2009; 101(5): 2563 - 2571.
[Abstract] [Full Text] [PDF]
V. Di Biase, G. J. Obermair, Z. Szabo, C. Altier, J. Sanguesa, E. Bourinet, and B. E. Flucher
Stable Membrane Expression of Postsynaptic CaV1.2 Calcium Channel Clusters Is Independent of Interactions with AKAP79/150 and PDZ Proteins
J. Neurosci., December 17, 2008; 28(51): 13845 - 13855.
[Abstract] [Full Text] [PDF]
D. G. Wheeler, C. F. Barrett, R. D. Groth, P. Safa, and R. W. Tsien
CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling
J. Cell Biol., December 1, 2008; 183(5): 849 - 863.
[Abstract] [Full Text] [PDF]
A. B. Parekh
Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function
J. Physiol., July 1, 2008; 586(13): 3043 - 3054.
[Abstract] [Full Text] [PDF]
J. A. White, B. C. McKinney, M. C. John, P. A. Powers, T. J. Kamp, and G. G. Murphy
Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice
Learn. Mem., January 3, 2008; 15(1): 1 - 5.
[Abstract] [Full Text] [PDF]
S. Kim, H.-M. Yun, J.-H. Baik, K. C. Chung, S.-Y. Nah, and H. Rhim
Functional Interaction of Neuronal Cav1.3 L-type Calcium Channel with Ryanodine Receptor Type 2 in the Rat Hippocampus
J. Biol. Chem., November 9, 2007; 282(45): 32877 - 32889.
[Abstract] [Full Text] [PDF]
M. I. Boulware, H. Kordasiewicz, and P. G. Mermelstein
Caveolin Proteins Are Essential for Distinct Effects of Membrane Estrogen Receptors in Neurons
J. Neurosci., September 12, 2007; 27(37): 9941 - 9950.
[Abstract] [Full Text] [PDF]
H.-G. Wang, M. S. George, J. Kim, C. Wang, and G. S. Pitt
Ca2+/Calmodulin Regulates Trafficking of CaV1.2 Ca2+ Channels in Cultured Hippocampal Neurons
J. Neurosci., August 22, 2007; 27(34): 9086 - 9093.
[Abstract] [Full Text] [PDF]
X.-M. Li, J.-M. Yang, D.-H. Hu, F.-Q. Hou, M. Zhao, X.-H. Zhu, Y. Wang, J.-G. Li, P. Hu, L. Chen, et al.
Contribution of Downregulation of L-type Calcium Currents to Delayed Neuronal Death in Rat Hippocampus after Global Cerebral Ischemia and Reperfusion
J. Neurosci., May 9, 2007; 27(19): 5249 - 5259.
[Abstract] [Full Text] [PDF]
W. Zhang, B. Star, W. R. A. K. J. S. Rajapaksha, and T. E. Fisher
Dehydration increases L-type Ca2+ current in rat supraoptic neurons
J. Physiol., April 1, 2007; 580(1): 181 - 193.
[Abstract] [Full Text] [PDF]
I. Calin-Jageman, K. Yu, R. A. Hall, L. Mei, and A. Lee
Erbin Enhances Voltage-Dependent Facilitation of Cav1.3 Ca2+ Channels through Relief of an Autoinhibitory Domain in the Cav1.3 {alpha}1 Subunit
J. Neurosci., February 7, 2007; 27(6): 1374 - 1385.
[Abstract] [Full Text] [PDF]
V. Zampini, P. Valli, G. Zucca, and S. Masetto
Single-Channel L-Type Ca2+ Currents in Chicken Embryo Semicircular Canal Type I and Type II Hair Cells
J Neurophysiol, August 1, 2006; 96(2): 602 - 612.
[Abstract] [Full Text] [PDF]
H. Khosravani and G. W. Zamponi
Voltage-gated calcium channels and idiopathic generalized epilepsies.
Physiol Rev, July 1, 2006; 86(3): 941 - 966.
[Abstract] [Full Text] [PDF]
L. Gao, L. A. C. Blair, G. D. Salinas, L. A. Needleman, and J. Marshall
Insulin-like growth factor-1 modulation of CaV1.3 calcium channels depends on Ca2+ release from IP3-sensitive stores and calcium/calmodulin kinase II phosphorylation of the alpha1 subunit EF hand.
J. Neurosci., June 7, 2006; 26(23): 6259 - 6268.
[Abstract] [Full Text] [PDF]
M. S. George and G. S. Pitt
The real estate of cardiac signaling: Location, location, location
PNAS, May 16, 2006; 103(20): 7535 - 7536.
[Full Text] [PDF]
J. Bradley, S. R. Carter, V. R. Rao, J. Wang, and S. Finkbeiner
Splice Variants of the NR1 Subunit Differentially Induce NMDA Receptor-Dependent Gene Expression
J. Neurosci., January 25, 2006; 26(4): 1065 - 1076.
[Abstract] [Full Text] [PDF]
J. D. Spafford, T. Dunn, A. B. Smit, N. I. Syed, and G. W. Zamponi
In Vitro Characterization of L-Type Calcium Channels and Their Contribution to Firing Behavior in Invertebrate Respiratory Neurons
J Neurophysiol, January 1, 2006; 95(1): 42 - 52.
[Abstract] [Full Text] [PDF]
A. M. Rajadhyaksha and B. E. Kosofsky
Psychostimulants, L-type Calcium Channels, Kinases, and Phosphatases
Neuroscientist, October 1, 2005; 11(5): 494 - 502.
[Abstract] [PDF]
W. J. Moody and M. M. Bosma
Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells
Physiol Rev, July 1, 2005; 85(3): 883 - 941.
[Abstract] [Full Text] [PDF]
M. I. Boulware, J. P. Weick, B. R. Becklund, S. P. Kuo, R. D. Groth, and P. G. Mermelstein
Estradiol Activates Group I and II Metabotropic Glutamate Receptor Signaling, Leading to Opposing Influences on cAMP Response Element-Binding Protein
J. Neurosci., May 18, 2005; 25(20): 5066 - 5078.
[Abstract] [Full Text] [PDF]
H. Zhang, A. Maximov, Y. Fu, F. Xu, T.-S. Tang, T. Tkatch, D. J. Surmeier, and I. Bezprozvanny
Association of CaV1.3 L-Type Calcium Channels with Shank
J. Neurosci., February 2, 2005; 25(5): 1037 - 1049.
[Abstract] [Full Text] [PDF]
P. A. Olson, T. Tkatch, S. Hernandez-Lopez, S. Ulrich, E. Ilijic, E. Mugnaini, H. Zhang, I. Bezprozvanny, and D. J. Surmeier
G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+ Channels Is Dependent on a Shank-Binding Domain
J. Neurosci., February 2, 2005; 25(5): 1050 - 1062.
[Abstract] [Full Text] [PDF]
D. Lipscombe, T. D. Helton, and W. Xu
L-Type Calcium Channels: The Low Down
J Neurophysiol, November 1, 2004; 92(5): 2633 - 2641.
[Abstract] [Full Text] [PDF]
A. Rajadhyaksha, I. Husson, S. S. Satpute, K. D. Kuppenbender, J. Q. Ren, R. M. Guerriero, D. G. Standaert, and B. E. Kosofsky
L-Type Ca2+ Channels Mediate Adaptation of Extracellular Signal-Regulated Kinase 1/2 Phosphorylation in the Ventral Tegmental Area after Chronic Amphetamine Treatment
J. Neurosci., August 25, 2004; 24(34): 7464 - 7476.
[Abstract] [Full Text] [PDF]
D. Chaudhuri, S.-Y. Chang, C. D. DeMaria, R. S. Alvania, T. W. Soong, and D. T. Yue
Alternative Splicing as a Molecular Switch for Ca2+/Calmodulin-Dependent Facilitation of P/Q-Type Ca2+ Channels
J. Neurosci., July 14, 2004; 24(28): 6334 - 6342.
[Abstract] [Full Text] [PDF]
H. Zhou, S.-A. Kim, E. A. Kirk, A. L. Tippens, H. Sun, F. Haeseleer, and A. Lee
Ca2+-Binding Protein-1 Facilitates and Forms a Postsynaptic Complex with Cav1.2 (L-Type) Ca2+ Channels
J. Neurosci., May 12, 2004; 24(19): 4698 - 4708.
[Abstract] [Full Text] [PDF]
Z. Liu, J. Ren, and T. H Murphy
Decoding of synaptic voltage waveforms by specific classes of recombinant high-threshold Ca2+ channels
J. Physiol., December 1, 2003; 553(2): 473 - 488.
[Abstract] [Full Text] [PDF]
N. Bannert, K. Vollhardt, B. Asomuddinov, M. Haag, H. Konig, S. Norley, and R. Kurth
PDZ Domain-mediated Interaction of Interleukin-16 Precursor Proteins with Myosin Phosphatase Targeting Subunits
J. Biol. Chem., October 24, 2003; 278(43): 42190 - 42199.
[Abstract] [Full Text] [PDF]
M. C. Sanguinetti and P. B. Bennett
Antiarrhythmic Drug Target Choices and Screening
Circ. Res., September 19, 2003; 93(6): 491 - 499.
[Abstract] [Full Text] [PDF]
R. D. Groth and P. G. Mermelstein
Brain-Derived Neurotrophic Factor Activation of NFAT (Nuclear Factor of Activated T-Cells)-Dependent Transcription: A Role for the Transcription Factor NFATc4 in Neurotrophin-Mediated Gene Expression
J. Neurosci., September 3, 2003; 23(22): 8125 - 8134.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|